Mechanisms of Siglec-F-Induced Eosinophil Apoptosis: A Role for Caspases but Not for SHP-1, Src Kinases, NADPH Oxidase or Reactive Oxygen

Functionally Competent Eosinophils Differentiated Ex Vivo in High Purity from Normal Mouse Bone Marrow

(2014) K. D. Dyer et al.   JOURNAL OF IMMUNOLOGY

Reslizumab for Poorly Controlled, Eosinophilic Asthma

(2011) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils

(2011) Ho Jeong Na et al.   CYTOKINE

Developmental, Malignancy-Related, and Cross-Species Analysis of Eosinophil, Mast Cell, and Basophil Siglec-8 Expression

(2011) Sherry A. Hudson et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Siglec-F Inhibition Reduces Esophageal Eosinophilia and Angiogenesis in a Mouse Model of Eosinophilic Esophagitis

(2011) Eitan Rubinstein et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Characterization of Expression of Glycan Ligands for Siglec-F in Normal Mouse Lungs

(2010) Jin P. Guo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti–IL-5 receptor α antibody, in a phase I study of subjects with mild asthma

(2010) William W. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab does not alter levels of eosinophils, T cells, and mast cells in the duodenal mucosa in eosinophilic esophagitis

(2010) Sébastien Conus et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

What targeting eosinophils has taught us about their role in diseases

(2010) Bruce S. Bochner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Basic and Clinical Immunology of Siglecs

(2009) Stephan von Gunten et al.   Annals of the New York Academy of Sciences

Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model

(2009) Dae Jin Song et al.   CLINICAL IMMUNOLOGY

Anti-Siglec-F Antibody Reduces Allergen-Induced Eosinophilic Inflammation and Airway Remodeling

(2009) D. J. Song et al.   JOURNAL OF IMMUNOLOGY

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils

(2008) N. Zimmermann et al.   ALLERGY

A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils

(2008) A. Munitz et al.   BLOOD

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells

(2008) Elizabeth A. Jacobsen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab

(2008) Marc E. Rothenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-5 Priming of Human Eosinophils Alters Siglec-8–Mediated Apoptosis Pathways

(2007) Esra Nutku-Bilir et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of FcεRI-dependent mediator release and calcium flux from human mast cells by sialic acid–binding immunoglobulin-like lectin 8 engagement

(2007) Hidenori Yokoi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY