Synthetic Siglec-9 Agonists Inhibit Neutrophil Activation Associated with COVID-19

Modulation of immune cell reactivity with cis-binding Siglec agonists

(2021) Corleone S. Delaveris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siglecs as Immune Cell Checkpoints in Disease

(2020) Shiteng Duan et al.   Annual Review of Immunology

CD24Fc protects against viral pneumonia in simian immunodeficiency virus-infected Chinese rhesus monkeys

(2020) Ren-Rong Tian et al.   Cellular & Molecular Immunology

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes

(2020) Mario Adán Moreno-Eutimio et al.   MICROBES AND INFECTION

Membrane-tethered mucin-like polypeptides sterically inhibit binding and slow fusion kinetics of influenza A virus

(2020) Corleone S. Delaveris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Mechanisms of NETosis

(2020) Hawa Racine Thiam et al.   Annual Review of Cell and Developmental Biology

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19

(2020) Coraline Radermecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Large-Scale Multi-omic Analysis of COVID-19 Severity

(2020) Katherine A. Overmyer et al.   Cell Systems

Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases

(2019) Caitlyn L. Holmes et al.   Journal of Immunology Research

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

(2019) José Perdomo et al.   Nature Communications

Phosphoinositides: multipurpose cellular lipids with emerging roles in cell death

(2019) Thanh Kha Phan et al.   CELL DEATH AND DIFFERENTIATION

Neutrophil Extracellular Traps Are Elevated in Patients with Pneumonia-related Acute Respiratory Distress Syndrome

(2019) Inès Bendib et al.   ANESTHESIOLOGY

TMT labeling for the masses: A robust and cost-efficient, in-solution labeling approach

(2019) Jana Zecha et al.   MOLECULAR & CELLULAR PROTEOMICS

Extracellular DNA traps in inflammation, injury and healing

(2019) Christoph Daniel et al.   Nature Reviews Nephrology

Glycans as Modulators for the Formation and Functional Properties of Neutrophil Extracellular Traps: Used by the Forces of Good and Evil

(2019) Kim F. Bornhöfft et al.   Frontiers in Immunology

Sialic acid–binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses

(2019) Heinz Läubli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phosphoproteomic Analyses Provide Insight into Molecular Mechanisms Underlying NETosis

(2019) Xiaoying Zhu et al.   PROTEOMICS

CD24 and Fc fusion protein protects SIVmac239-infected Chinese rhesus macaque against progression to AIDS

(2018) Ren-Rong Tian et al.   ANTIVIRAL RESEARCH

Interaction of factor VII activating protease (FSAP) with neutrophil extracellular traps (NETs)

(2018) Simona Grasso et al.   THROMBOSIS RESEARCH

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

(2018) Michal A. Stanczak et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting sialic acid–Siglec interactions to reverse immune suppression in cancer

(2017) Olivia Joan Adams et al.   GLYCOBIOLOGY

TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA

(2017) Christian Lood et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A High-Throughput Real-Time Imaging Technique To Quantify NETosis and Distinguish Mechanisms of Cell Death in Human Neutrophils

(2017) Sarthak Gupta et al.   JOURNAL OF IMMUNOLOGY

In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review

(2017) Tamara Hoppenbrouwers et al.   PLoS One

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Formation of Neutrophil Extracellular Traps under Low Oxygen Level

(2016) Katja Branitzki-Heinemann et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Go Viral

(2016) Günther Schönrich et al.   Frontiers in Immunology

Glycocalyx Engineering with a Recycling Glycopolymer that Increases Cell Survival In Vivo

(2015) Elliot C. Woods et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells

(2015) Suguru Saito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane

(2015) Jeremy M. Baskin et al.   NATURE CELL BIOLOGY

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

(2014) Heinz Läubli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Click and Pick: Identification of Sialoside Analogues for Siglec-Based Cell Targeting

(2012) Cory D. Rillahan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9

(2012) B. Khatua et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

(2011) Venizelos Papayannopoulos et al.   PLoS One

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE