Aged Breast Extracellular Matrix Drives Mammary Epithelial Cells to an Invasive and Cancer‐Like Phenotype

Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: a systematic review and meta-analysis

(2021) Hanfang Jiang et al.   BMC CANCER

c-Myb interferes with inflammatory IL1α-NF-κB pathway in breast cancer cells

(2021) Monika Dúcka et al.   NEOPLASIA

Celastrol attenuates the inflammatory response by inhibiting IL‑1β expression in triple‑negative breast cancer cells

(2021) Daeun You et al.   ONCOLOGY REPORTS

Breast cancer models: Engineering the tumor microenvironment

(2020) Gokhan Bahcecioglu et al.   Acta Biomaterialia

Single-Cell Transcriptomic Atlas of Primate Ovarian Aging

(2020) Si Wang et al.   CELL

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

(2020) Tito Panciera et al.   NATURE MATERIALS

Substrate stiffness directs the phenotype and polarization state of cord blood derived macrophages

(2020) Rebecca A. Scott et al.   Acta Biomaterialia

Effect of cellular and ECM aging on human iPSC-derived cardiomyocyte performance, maturity and senescence

(2020) S. Gulberk Ozcebe et al.   BIOMATERIALS

Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing

(2020) Carman Man-Chung Li et al.   Cell Reports

ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis

(2019) Vinit Shanbhag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial Viscoelasticity Is Regulated by Mechanosensitive E-cadherin Turnover

(2019) K. Venkatesan Iyer et al.   CURRENT BIOLOGY

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure–Activity Relationships

(2019) Leo Leung et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Role of the Extracellular Matrix in Cancer Stemness

(2019) Sameera Nallanthighal et al.   Frontiers in Cell and Developmental Biology

The impact of decellularization methods on extracellular matrix derived hydrogels

(2019) Julia Fernández-Pérez et al.   Scientific Reports

Stromal cell-laden 3D hydrogel microwell arrays as tumor microenvironment model for studying stiffness dependent stromal cell-cancer interactions

(2018) Xiaoshan Yue et al.   BIOMATERIALS

Normal breast-derived epithelial cells with luminal and intrinsic subtype-enriched gene expression document inter-individual differences in their differentiation cascade

(2018) Brijesh Kumar et al.   CANCER RESEARCH

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

With Great Age Comes Great Metastatic Ability: Ovarian Cancer and the Appeal of the Aging Peritoneal Microenvironment

(2018) Elizabeth Harper et al.   Cancers

Hydrogels of agarose, and methacrylated gelatin and hyaluronic acid are more supportive for in vitro meniscus regeneration than three dimensional printed polycaprolactone scaffolds

(2018) Gokhan Bahcecioglu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells

(2018) Daniella Bianchi-Frias et al.   MOLECULAR CANCER RESEARCH

High expression of CCL2 in tumor cells and abundant infiltration with CD14 positive macrophages predict early relapse in breast cancer

(2018) Marja Heiskala et al.   VIRCHOWS ARCHIV

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

(2018) Amanpreet Kaur et al.   Cancer Discovery

Cell behavior on the alginate-coated PLLA/PLGA scaffolds

(2018) Gokhan Bahcecioglu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Simultaneous epitope and transcriptome measurement in single cells

(2017) Marlon Stoeckius et al.   NATURE METHODS

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

PHLDA1 (pleckstrin homology-like domain, family A, member 1) knockdown promotes migration and invasion of MCF10A breast epithelial cells

(2017) Naieli Bonatto et al.   Cell Adhesion & Migration

Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130CAS/Src inhibition by eribulin

(2017) Nicholas F. Dybdal-Hargreaves et al.   Oncotarget

The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks

(2017) Jan R. Aunan et al.   Aging and Disease

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype

(2017) Shawn P. Carey et al.   Scientific Reports

Application of Targeted Mass Spectrometry for the Quantification of Sirtuins in the Central Nervous System

(2016) T. Jayasena et al.   Scientific Reports

CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer

(2015) Ming T. Cheah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-extracellular matrix interactions: Identification of tools associated with breast cancer progression

(2015) Marta Giussani et al.   SEMINARS IN CANCER BIOLOGY

Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients

(2015) Miguel Angel Pavón et al.   Oncotarget

Substrate Stiffness Regulates Proinflammatory Mediator Production through TLR4 Activity in Macrophages

(2015) Michelle L. Previtera et al.   PLoS One

Lysyl Oxidase Contributes to Mechanotransduction-Mediated Regulation of Transforming Growth Factor-β Signaling in Breast Cancer Cells

(2015) Molly A. Taylor et al.   NEOPLASIA

In vitro modeling of the prostate cancer microenvironment

(2014) Stuart J. Ellem et al.   ADVANCED DRUG DELIVERY REVIEWS

Increasing matrix stiffness upregulates vascular endothelial growth factor expression in hepatocellular carcinoma cells mediated by integrin β1

(2014) Yinying Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiogenin interacts with the plasminogen activation system at the cell surface of breast cancer cells to regulate plasmin formation and cell migration

(2014) Sujoy Dutta et al.   Molecular Oncology

Age-Specific Changes in Intrinsic Breast Cancer Subtypes: A Focus on Older Women

(2014) E. O. Jenkins et al.   ONCOLOGIST

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

(2014) Alexandra Naba et al.   eLife

Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro

(2013) C. Williams et al.   Acta Biomaterialia

A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma

(2013) Peikai Chen et al.   BMC BIOINFORMATICS

CD14 regulates gastric cancer cell epithelial-mesenchymal transition and invasion in vitro

(2013) KANG LI et al.   ONCOLOGY REPORTS

Collagen XV Inhibits Epithelial to Mesenchymal Transition in Pancreatic Adenocarcinoma Cells

(2013) Anthony G. Clementz et al.   PLoS One

The Relationship of Mammographic Density and Age: Implications for Breast Cancer Screening

(2012) Cristina M. Checka et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Inflamm-aging of the stem cell niche: Breast cancer as a paradigmatic example

(2011) Massimiliano Bonafè et al.   BIOESSAYS

Matrix compliance and RhoA direct the differentiation of mammary progenitor cells

(2011) Cecillia Lui et al.   Biomechanics and Modeling in Mechanobiology

The Lysyl Oxidase Propeptide Interacts with the Receptor-Type Protein Tyrosine Phosphatase Kappa and Inhibits  -Catenin Transcriptional Activity in Lung Cancer Cells

(2011) N. Sanchez-Morgan et al.   MOLECULAR AND CELLULAR BIOLOGY

Tuberin Regulates E-Cadherin Localization

(2010) Elizabeth A. Barnes et al.   AMERICAN JOURNAL OF PATHOLOGY

Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression

(2010) Cynthia C. Sprenger et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-Conditioned Macrophages Secrete Migration-Stimulating Factor: A New Marker for M2-Polarization, Influencing Tumor Cell Motility

(2010) G. Solinas et al.   JOURNAL OF IMMUNOLOGY

The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia

(2009) Ruth Schietke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments

(2008) Mark A. LaBarge et al.   Integrative Biology

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

(2008) Kaylene J. Simpson et al.   NATURE CELL BIOLOGY

Impact of aging on the biology of breast cancer

(2007) Christopher C. Benz   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY