Journal
ONCOTARGET
Volume 6, Issue 30, Pages 29016-29033Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.5032
Keywords
HNSCC; SERPINE1; prognosis; biomarker; AKT
Categories
Funding
- AGAUR [SGR1437]
- CIBER-BBN [CB06/01/1031]
- Instituto de Salud Carlos III [PI12/01861, PI14/01918]
- FEDER [PI12/01861, PI14/01918]
- Instituto de Salut Carlos III [PI11/00525]
- Ayudas Merck Serono (Fundacion Salud)
Ask authors/readers for more resources
High SERPINE1 expression is a common event in head and neck squamous cell carcinoma (HNSCC); however, whether it plays a role in determining clinical outcome remains still unknown. We studied SERPINE1 as a prognostic marker in two HNSCC patient cohorts. In a retrospective study (n = 80), high expression of SERPINE1 was associated with poor progression-free (p = 0.022) and cancer-specific (p = 0.040) survival. In a prospective study (n = 190), high SERPINE1 expression was associated with poor local recurrence-free (p = 0.022), progression-free (p = 0.002) and cancerspecific (p = 0.006) survival. SERPINE1 expression was identified as an independent risk factor for progression-free survival in patients treated with chemo-radiotherapy or radiotherapy (p = 0.043). In both patient cohorts, high SERPINE1 expression increased the risk of metastasis spread (p = 0.045; p = 0.029). The association between SERPINE1 expression and survival was confirmed using the HNSCC cohort included in The Cancer Genome Atlas project (n = 507). Once again, patients showing high expression had a poorer survival (p < 0.001). SERPINE1 over-expression in HNSCC cells reduced cell proliferation and enhanced migration. It also protected cells from cisplatin-induced apoptosis, which was accompanied by PI3K/AKT pathway activation. Downregulation of SERPINE1 expression had the opposite effect. We propose SERPINE1 expression as a prognostic marker that could be used to stratify HNSCC patients according to their risk of recurrence.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available