Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 79-80, Issue -, Pages 214-221Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2014.04.008
Keywords
Prostate; Prostate cancer; Microenvironment; Stroma; Scaffolds; Matrix; 2D; 3D
Categories
Funding
- Australian National Health and Medical Research Council [SJE: APP1003247, GPR: APP1002648]
- Movember / Prostate Cancer Foundation of Australia [SJE GPR: NCG4712]
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Prostate cancer is the most commonly diagnosed malignancy in men and advanced disease is incurable. Model systems are a fundamental tool for research and many in vitro models of prostate cancer use cancer cell lines in monoculture. Although these have yielded significant insight they are inherently limited by virtue of their two-dimensional (2D) growth and inability to include the influence of tumour microenvironment These major limitations can be overcome with the development of newer systems that more faithfully recreate and mimic the complex in vivo multi-cellular, three-dimensional (3D) microenvironment This article presents the current state of in vitro models for prostate cancer, with particular emphasis on 3D systems and the challenges that remain before their potential to advance our understanding of prostate disease and aid in the development and testing of new therapeutic agents can be realised. (C) 2014 Elsevier B.V. All rights reserved.
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