Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-12-31
DOI
10.3389/fphar.2021.828856
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling
- (2021) Size Li et al. ARCHIVES OF TOXICOLOGY
- Resveratrol for cancer therapy: Challenges and future perspectives
- (2021) Boxu Ren et al. CANCER LETTERS
- Long non-coding RNAs and circular RNAs in tumor angiogenesis: From mechanisms to clinical significance
- (2021) Chen-Guang Liu et al. Molecular Therapy-Oncolytics
- Celastrol in cancer therapy: Recent developments, challenges and prospects
- (2021) Hannah Ying Lim et al. CANCER LETTERS
- Artesunate induces apoptosis, autophagy and ferroptosis in diffuse large B cell lymphoma cells by impairing STAT3 signaling
- (2021) Yingying Chen et al. CELLULAR SIGNALLING
- Ferroptosis: a novel mechanism of artemisinin and its derivatives in cancer therapy
- (2020) Shunqin Zhu et al. CURRENT MEDICINAL CHEMISTRY
- A first-in-human proof-of-concept trial of intravaginal artesunate to treat cervical intraepithelial neoplasia 2/3 (CIN2/3)
- (2020) Cornelia L. Trimble et al. GYNECOLOGIC ONCOLOGY
- Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression
- (2020) Yue Yang et al. Biomed Research International
- Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells
- (2020) Xu Yao et al. ACTA PHARMACOLOGICA SINICA
- Malaria eradication
- (2020) Jigang Wang et al. LANCET
- Autophagy-dependent cell cycle arrest in esophageal cancer cells exposed to dihydroartemisinin
- (2020) Qiang Ma et al. Chinese Medicine
- Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma
- (2020) Zhong-jie Li et al. ACTA PHARMACOLOGICA SINICA
- Construction and anti-tumor activities of disulfide-linked docetaxel-dihydroartemisinin nanoconjugates
- (2020) Ning Li et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- PEGylated-Paclitaxel and Dihydroartemisinin Nanoparticles for Simultaneously Delivering Paclitaxel and Dihydroartemisinin to Colorectal Cancer
- (2020) Cao Dai Phung et al. PHARMACEUTICAL RESEARCH
- Dihydroartemisinin inhibits the migration of esophageal cancer cells by inducing autophagy
- (2020) Xiao Chen et al. Oncology Letters
- Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- (2020) Yolanda Augustin et al. PHARMACOLOGY & THERAPEUTICS
- Artesunate exhibits synergistic anti-cancer effects with cisplatin on lung cancer A549 cells by inhibiting MAPK pathway
- (2020) Wen Li et al. GENE
- Triple artemisinin-based combination therapies for malaria: proceed with caution
- (2020) Jigang Wang et al. LANCET
- Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers
- (2020) Yu Zhou et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
- (2019) Guo-Qing Chen et al. CELL DEATH AND DIFFERENTIATION
- Drug repurposing: a promising tool to accelerate the drug discovery process
- (2019) Vineela Parvathaneni et al. DRUG DISCOVERY TODAY
- Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors
- (2019) Xiaopin Duan et al. Nature Communications
- Recent Progress in Ferroptosis Inducers for Cancer Therapy
- (2019) Chen Liang et al. ADVANCED MATERIALS
- Programmed Release of Dihydroartemisinin for Synergistic Cancer Therapy Using a CaCO3 Mineralized Metal-Organic Framework
- (2019) Xiuyan Wan et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Artesunate promotes sensitivity to sorafenib in hepatocellular carcinoma
- (2019) Wu Jing et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Low density lipoprotein receptor (LDLR)-targeted lipid nanoparticles for the delivery of sorafenib and Dihydroartemisinin in liver cancers
- (2019) Zhengfeng Wang et al. LIFE SCIENCES
- Dihydroartemisinin potentiates antitumor activity of 5-fluorouracil against a resistant colorectal cancer cell line
- (2018) Zhihan Yao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A phase I study of intravenous artesunate in patients with advanced solid tumor malignancies
- (2018) John F. Deeken et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Tumor-targeting core-shell structured nanoparticles for drug procedural controlled release and cancer sonodynamic combined therapy
- (2018) Lei Wang et al. JOURNAL OF CONTROLLED RELEASE
- Artesunate promotes G2/M cell cycle arrest in MCF7 breast cancer cells through ATM activation
- (2018) Lijuan Wen et al. Breast Cancer
- Dihydroartemisinin increases gemcitabine therapeutic efficacy in ovarian cancer by inducing reactive oxygen species
- (2018) Shengcai Yang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Long-term add-on therapy (compassionate use) with oral artesunate in patients with metastatic breast cancer after participating in a phase I study (ARTIC M33/2)
- (2018) Cornelia von Hagens et al. PHYTOMEDICINE
- Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer
- (2018) Yuyuan Yao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin
- (2018) Jing Du et al. FREE RADICAL BIOLOGY AND MEDICINE
- Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action
- (2017) Yin Kwan Wong et al. MEDICINAL RESEARCH REVIEWS
- Dihydroartemisinin and gefitinib synergistically inhibit NSCLC cell growth and promote apoptosis via the Akt/mTOR/STAT3 pathway
- (2017) Hong Jin et al. Molecular Medicine Reports
- Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty Acid Synthesis and the NF-κB Pathway
- (2017) Xiao Chen et al. MOLECULES
- Drug repurposing in cancer
- (2017) Linda Sleire et al. PHARMACOLOGICAL RESEARCH
- From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy
- (2017) Thomas Efferth SEMINARS IN CANCER BIOLOGY
- Artesunate suppresses the viability and mobility of prostate cancer cells through UCA1, the sponge of miR-184
- (2017) Yan Zhou et al. Oncotarget
- Combined treatment with artesunate and bromocriptine has synergistic anticancer effects in pituitary adenoma cell lines
- (2017) Xin Wang et al. Oncotarget
- Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis
- (2017) Jong-Lyel Roh et al. Redox Biology
- Combination of onconase and dihydroartemisinin synergistically suppresses growth and angiogenesis of non–small-cell lung carcinoma and malignant mesothelioma
- (2016) Ruling Shen et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Magnetically guided delivery of DHA and Fe ions for enhanced cancer therapy based on pH-responsive degradation of DHA-loaded Fe 3 O 4 @C@MIL-100(Fe) nanoparticles
- (2016) Dongdong Wang et al. BIOMATERIALS
- Controllable synthesis of dual-MOFs nanostructures for pH-responsive artemisinin delivery, magnetic resonance and optical dual-model imaging-guided chemo/photothermal combinational cancer therapy
- (2016) Dongdong Wang et al. BIOMATERIALS
- Evaluation of artemisinins for the treatment of acute myeloid leukemia
- (2016) Christina D. Drenberg et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Enhanced Efficacy of Artemisinin Loaded in Transferrin-Conjugated Liposomes versus Stealth Liposomes against HCT-8 Colon Cancer Cells
- (2016) Isabella Leto et al. ChemMedChem
- Artesunate induces ROS-dependent apoptosis via a Bax-mediated intrinsic pathway in Huh-7 and Hep3B cells
- (2016) Yilin Pang et al. EXPERIMENTAL CELL RESEARCH
- Mechanism of dihydroartemisinin-induced apoptosis in prostate cancer PC3 cells: An iTRAQ-based proteomic analysis
- (2016) Ge Xu et al. LIFE SCIENCES
- Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate
- (2016) Anna L. Greenshields et al. MOLECULAR CARCINOGENESIS
- Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis
- (2016) JIANGUANG JIA et al. Molecular Medicine Reports
- In vitro and in vivo inhibition of tumor cell viability by combined dihydroartemisinin and doxorubicin treatment, and the underlying mechanism
- (2016) Xiang Tai et al. Oncology Letters
- Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signaling
- (2016) Yunli Tong et al. Oncotarget
- Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence
- (2016) Nancy Berte et al. Oncotarget
- Enhancing activity of artesunate against breast cancer cells via induced-apoptosis pathway by loading into lipid carriers
- (2016) Tuan Hiep Tran et al. Artificial Cells Nanomedicine and Biotechnology
- Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling
- (2016) Lifeng Jia et al. PLoS One
- Self-assembled targeted nanoparticles based on transferrin-modified eight-arm-polyethylene glycol–dihydroartemisinin conjugate
- (2016) Kefeng Liu et al. Scientific Reports
- Development and Evaluation of Artesunate-Loaded Chitosan-Coated Lipid Nanocapsule as a Potential Drug Delivery System Against Breast Cancer
- (2015) Tuan Hiep Tran et al. AAPS PHARMSCITECH
- Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51
- (2015) Bingliang Wang et al. CANCER BIOLOGY & THERAPY
- Artesunate induces ROS- and p38 MAPK-mediated apoptosis and counteracts tumor growthin vivoin embryonal rhabdomyosarcoma cells
- (2015) Sara Beccafico et al. CARCINOGENESIS
- Artesunate Induces SKM-1 Cells Apoptosis by Inhibiting Hyperactive β-catenin Signaling Pathway
- (2015) Na Xu et al. International Journal of Medical Sciences
- pH-Responsive Artemisinin Dimer in Lipid Nanoparticles Are Effective Against Human Breast Cancer in a Xenograft Model
- (2015) Yitong J. Zhang et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Mn(ii) mediated degradation of artemisinin based on Fe3O4@MnSiO3-FA nanospheres for cancer therapy in vivo
- (2015) Jian Chen et al. Nanoscale
- Cytoprotective effects of ferritin on doxorubicin-induced breast cancer cell death
- (2015) BENJAPORN BURANRAT et al. ONCOLOGY REPORTS
- Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis
- (2015) Da Eun Jeong et al. Oncotarget
- Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model
- (2015) Chulwon Kim et al. Oncotarget
- A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer
- (2015) Sanjeev Krishna et al. EBioMedicine
- Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cells
- (2014) Kai Chen et al. ANTI-CANCER DRUGS
- Dihydroartemisinine Enhances Dictamnine-induced Apoptosis via a Caspase Dependent Pathway in Human Lung Adenocarcinoma A549 Cells
- (2014) Fu-Fei An et al. Asian Pacific Journal of Cancer Prevention
- Synergism of Cytotoxicity Effects of Triptolide and Artesunate Combination Treatment in Pancreatic Cancer Cell Lines
- (2014) Yao Liu et al. Asian Pacific Journal of Cancer Prevention
- Multifunctional mesoporous nanoparticles as pH-responsive Fe2+ reservoirs and artemisinin vehicles for synergistic inhibition of tumor growth
- (2014) Jian Chen et al. BIOMATERIALS
- Population pharmacokinetics of artesunate and dihydroartemisinin during long-term oral administration of artesunate to patients with metastatic breast cancer
- (2014) Therese Ericsson et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma
- (2014) SHUNQIN ZHU et al. ONCOLOGY REPORTS
- Synergistic anti-cancer activity of the combination of dihydroartemisinin and doxorubicin in breast cancer cells
- (2014) Guo-Sheng Wu et al. Pharmacological Reports
- Artemisinin derivative artesunate induces radiosensitivity in cervical cancer cells in vitro and in vivo
- (2014) Judong Luo et al. Radiation Oncology
- Artemisinin triggers a G1 cell cycle arrest of human Ishikawa endometrial cancer cells and inhibits cyclin-dependent kinase-4 promoter activity and expression by disrupting nuclear factor-κB transcriptional signaling
- (2013) Kalvin Q. Tran et al. ANTI-CANCER DRUGS
- The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo
- (2013) Wei Jiang et al. Asian Pacific Journal of Cancer Prevention
- In vivostudy of effects of artesunate nanoliposomes on human hepatocellular carcinoma xenografts in nude mice
- (2013) Meihua Jin et al. DRUG DELIVERY
- Enhancement effect of dihydroartemisinin on human γδ T cell proliferation and killing pancreatic cancer cells
- (2013) Zhong-Hai Zhou et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- DHA regulates angiogenesis and improves the efficiency of CDDP for the treatment of lung carcinoma
- (2013) Jia-Li Zhang et al. MICROVASCULAR RESEARCH
- pH-Responsive Artemisinin Derivatives and Lipid Nanoparticle Formulations Inhibit Growth of Breast Cancer Cells In Vitro and Induce Down-Regulation of HER Family Members
- (2013) Yitong J. Zhang et al. PLoS One
- Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells
- (2012) Chenjuan Zhou et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Dihydroartemisinin Enhances Apo2L/TRAIL-Mediated Apoptosis in Pancreatic Cancer Cells via ROS-Mediated Up-Regulation of Death Receptor 5
- (2012) Rui Kong et al. PLoS One
- Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity
- (2012) Zeng Wang et al. FEBS Open Bio
- Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes
- (2011) Antony S. Tin et al. ANTI-CANCER DRUGS
- Dihydroartemisinin inhibits angiogenesis in pancreatic cancer by targeting the NF-κB pathway
- (2011) Shuang-Jia Wang et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo
- (2011) Qiang Xu et al. Journal of Zhejiang University-SCIENCE B
- Artesunate Induces Oxidative DNA Damage, Sustained DNA Double-Strand Breaks, and the ATM/ATR Damage Response in Cancer Cells
- (2011) N. Berdelle et al. MOLECULAR CANCER THERAPEUTICS
- Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer
- (2011) Shisan Bao ONCOLOGY REPORTS
- Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCα/Raf/MAPKs and NF-κB/AP-1-dependent mechanisms
- (2010) Yong Pil Hwang et al. BIOCHEMICAL PHARMACOLOGY
- Dihydroartemisinin inactivates NF-κB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo
- (2010) Shuang-Jia Wang et al. CANCER LETTERS
- First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases
- (2010) Suhail Ahmed Kabeer Rasheed et al. INTERNATIONAL JOURNAL OF CANCER
- The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies
- (2010) Wai M. Liu et al. INTERNATIONAL JOURNAL OF CANCER
- Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production
- (2010) Anne Hamacher-Brady et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Artesunate mitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase
- (2010) Qing-Ping Zeng et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells
- (2010) Tan Weifeng et al. PHYTOMEDICINE
- Pharmacokinetic Profiles of Artesunate After Single Intravenous Doses at 0.5, 1, 2, 4, and 8 mg/kg in Healthy Volunteers: A Phase I Study
- (2009) Qigui Li et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells
- (2009) Mahmoud Youns et al. BIOCHEMICAL PHARMACOLOGY
- Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines
- (2009) Martin Michaelis et al. BIOCHEMICAL PHARMACOLOGY
- Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo
- (2009) Ji-Hui Du et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate
- (2009) Efferth INTERNATIONAL JOURNAL OF ONCOLOGY
- Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: involvement of cell cycle arrest and inactivation of nuclear factor-κB
- (2009) Hua Chen et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action
- (2008) J. Hou et al. CLINICAL CANCER RESEARCH
- Absence of time-dependent artesunate pharmacokinetics in healthy subjects during 5-day oral administration
- (2008) L. T. Diem Thuy et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of beta-catenin and E-cadherin
- (2008) Lin-Na Li et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression
- (2008) Jamin A. Willoughby et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy
- (2008) Tao Chen et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started