Journal
MOLECULAR THERAPY-ONCOLYTICS
Volume 22, Issue -, Pages 336-354Publisher
CELL PRESS
DOI: 10.1016/j.omto.2021.07.001
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Funding
- National Natural Science Foundation of China [81872412]
- Natural Science Foundation of Hubei Province, China [2019CFB591]
- Bureau of Science and Technology of Jingzhou Municipality, China [2020CB21-35]
- Guangdong Provincial-level Special Funds for Promoting High-quality Economic Development, China [2020032]
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Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) play crucial roles in cancer progression by influencing angiogenesis, but their specific mechanisms and potential clinical applications in tumor progression are still unclear.
Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) execute a wide array of functions in physiological and pathological processes, including tumor progression. Angiogenesis, an elaborate multistep process driving new blood vessel formation, accelerates cancer progression by supplying nutrients and energy. Dysregulated lncRNAs and circRNAs can reportedly impact cancer progression by influencing angiogenesis. However, the expanding landscape of lncRNAs and circRNAs in tumor progression-dependent angiogenesis remains largely unknown. This review summarizes the major functions of angiogenic lncRNAs (Angio-LncRs) and angiogenic circRNAs (termed Angio-CircRs) and their cancer mechanisms. Moreover, we highlight the commonalities of lncRNAs and circRNAs in epigenetic, transcriptional, and post-transcriptional regulation as well as illustrate how Angio-LncRs and Angio-CircRs induce cancer onset and progression. We also discuss their potential clinical applications in diagnosis, prognosis, and anti-angiogenic therapies.
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