New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease

Salvianolic Acid B Protects Against Fatty Acid-Induced Renal Tubular Injury via Inhibition of Endoplasmic Reticulum Stress

(2021) Xiaoyi Mai et al.   Frontiers in Pharmacology

Mechanisms and Efficacy of Chinese Herbal Medicines in Chronic Kidney Disease

(2021) Mingming Zhao et al.   Frontiers in Pharmacology

Efficacy and Safety of Tanshinone for Chronic Kidney Disease: A Meta-Analysis

(2020) Yao Zhou et al.   Evidence-based Complementary and Alternative Medicine

Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes

(2020) Xueling Li et al.   Frontiers in Physiology

Anti-apoptosis mechanism of triptolide based on network pharmacology in focal segmental glomerulosclerosis rats

(2020) Yayu Li et al.   BIOSCIENCE REPORTS

Highly bioavailable berberine formulation ameliorates diabetic nephropathy through the inhibition of glomerular mesangial matrix expansion and the activation of autophagy

(2020) Meishuang Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting the progression of chronic kidney disease

(2020) Marta Ruiz-Ortega et al.   Nature Reviews Nephrology

Efficacy and safety of Abelmoschus manihot for IgA nephropathy: A multicenter randomized clinical trial

(2020) Ping Li et al.   PHYTOMEDICINE

Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis

(2020) Yang Hu et al.   Molecular Medicine Reports

Puerarin alleviates cisplatin‑induced acute renal damage and upregulates microRNA‑31‑related signaling

(2020) Zhen Wu et al.   Experimental and Therapeutic Medicine

Tripterygium wilfordii Hook F Treatment for Stage IV Diabetic Nephropathy: Protocol for a Prospective, Randomized Controlled Trial

(2020) Xu Lengnan et al.   Biomed Research International

The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy

(2020) Xiaohui Xu et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Efficacy of tripterygium glycosides combined with Angiotensin II receptor blocker on diabetic nephropathy: a meta-analysis

(2020) Xue Wu et al.   BIOSCIENCE REPORTS

Integrated Network Pharmacology Analysis and Pharmacological Evaluation to Explore the Active Components and Mechanism of Abelmoschus manihot (L.) Medik. on Renal Fibrosis

(2020) Lifei Gu et al.   Drug Design Development and Therapy

Total Flavones of Abelmoschus manihot Remodels Gut Microbiota and Inhibits Microinflammation in Chronic Renal Failure Progression by Targeting Autophagy-Mediated Macrophage Polarization

(2020) Yue Tu et al.   Frontiers in Pharmacology

Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1–Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway

(2020) Yu Pang et al.   Frontiers in Pharmacology

Standard Puerarin Prevents Diabetic Renal Damage by Inhibiting miRNA-140-5p Expression

(2020) Yanmei Xu et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Triptolide attenuates renal damage by limiting inflammatory responses in DOCA-salt hypertension

(2020) Jing Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tanshinone IIA Ameliorates Streptozotocin-Induced Diabetic Nephropathy, Partly by Attenuating PERK Pathway-Induced Fibrosis

(2020) Shujuan Xu et al.   Drug Design Development and Therapy

Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats

(2019) Hong-feng Zhang et al.   Oxidative Medicine and Cellular Longevity

Clinical efficacy and safety of Tripterygium wilfordii Hook in the treatment of diabetic kidney disease stage IV

(2019) Daijin Ren et al.   MEDICINE

Salvianolic acid A alleviates the renal damage in rats with chronic renal failure

(2019) Guangming Zhang et al.   Acta Cirurgica Brasileira

Shen Shuai IIRecipe attenuates renal injury and fibrosis in chronic kidney disease by regulating NLRP3 inflammasome and Sirt1/Smad3 deacetylation pathway

(2019) Meng Wang et al.   BMC Complementary and Alternative Medicine

Therapeutic and antiproteinuric effects of salvianolic acid A in combined with low-dose prednisone in minimal change disease rats: Involvement of PPARγ/Angptl4 and Nrf2/HO-1 pathways

(2019) Xuekai Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Abelmoschus manihot for Diabetic Nephropathy: A Systematic Review and Meta-Analysis

(2019) Liwei Shi et al.   Evidence-based Complementary and Alternative Medicine

Total Extracts of Abelmoschus manihot L. Attenuates Adriamycin-Induced Renal Tubule Injury via Suppression of ROS-ERK1/2-Mediated NLRP3 Inflammasome Activation

(2019) Wei Li et al.   Frontiers in Pharmacology

Effects and Mechanism of Tanshinone II A in Proliferation, Apoptosis, and Migration of Human Colon Cancer Cells

(2019) Junlai Xue et al.   MEDICAL SCIENCE MONITOR

Berberine protects against diabetic kidney disease via promoting PGC‐1α‐regulated mitochondrial energy homeostasis

(2019) Xin Qin et al.   BRITISH JOURNAL OF PHARMACOLOGY

The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice

(2019) Zhengzheng Liao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes

(2019) Yifei Zhong et al.   Nature Communications

Efficacy and Safety of Sodium Tanshinone IIA Sulfonate Injection on Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

(2019) Junyao Xu et al.   Frontiers in Pharmacology

Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats

(2018) Hong-feng Zhang et al.   ACTA PHARMACOLOGICA SINICA

Puerarin improves methotrexate-induced renal damage by up-regulating renal expression of Oat1 and Oat3 in vivo and in vitro

(2018) Qi Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Tanshinone IIA Attenuates Contrast-Induced Nephropathy via Nrf2 Activation in Rats

(2018) Rulian Liang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Modulations of Keap1-Nrf2 signaling axis by TIIA ameliorated the oxidative stress-induced myocardial apoptosis

(2018) Shi-Hai Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Triptolide Attenuates Renal Tubular Epithelial-mesenchymal Transition Via the MiR-188-5p-mediated PI3K/AKT Pathway in Diabetic Kidney Disease

(2018) Mei Xue et al.   International Journal of Biological Sciences

Chronic Infusion of Berberine into the Hypothalamic Paraventricular Nucleus Attenuates Hypertension and Sympathoexcitation via the ROS/Erk1/2/iNOS Pathway

(2018) Hua Tian et al.   PHYTOMEDICINE

Supplementation of Abelmoschus manihot Ameliorates Diabetic Nephropathy and Hepatic Steatosis by Activating Autophagy in Mice

(2018) Hwajin Kim et al.   Nutrients

Multi-glycoside of Tripterygium wilfordii Hook. f. attenuates glomerulosclerosis in a rat model of diabetic nephropathy by exerting anti-microinflammatory effects without affecting hyperglycemia

(2017) Wei Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Triptolide prevents extracellular matrix accumulation in experimental diabetic kidney disease by targeting microRNA-137/Notch1 pathway

(2017) Fei Han et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Renal protective effect and action mechanism of Huangkui capsule and its main five flavonoids

(2017) Hong-Die Cai et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective effect of berberine on renal fibrosis caused by diabetic nephropathy

(2017) Zhong Li et al.   Molecular Medicine Reports

Total flavones of Abelmoschus manihot improve diabetic nephropathy by inhibiting the iRhom2/TACE signalling pathway activity in rats

(2017) Su Liu et al.   PHARMACEUTICAL BIOLOGY

Puerarin attenuates cisplatin-induced rat nephrotoxicity: The involvement of TLR4/NF-κB signaling pathway

(2017) Xu Ma et al.   PLoS One

Puerarin attenuates renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis via MAPK signal pathways in vivo and in vitro

(2017) Xiangjun Zhou et al.   RENAL FAILURE

Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation

(2017) Xia Chen et al.   Oncotarget

Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes

(2017) Xueling Li et al.   Scientific Reports

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

(2017) Xiao-yu Li et al.   Molecular Therapy-Nucleic Acids

Triptolide Improves Diabetic Nephropathy by Regulating Th Cell Balance and Macrophage Infiltration in Rat Models of Diabetic Nephropathy

(2016) H. Guo et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, improves diabetic nephropathy via activating peroxisome proliferator–activated receptor (PPAR)-α/γ and attenuating endoplasmic reticulum stress in rats

(2016) Jing Ge et al.   JOURNAL OF ETHNOPHARMACOLOGY

The global burden of chronic kidney disease: estimates, variability and pitfalls

(2016) Richard J. Glassock et al.   Nature Reviews Nephrology

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Anti-hypertensive and renoprotective effects of berberine in spontaneously hypertensive rats

(2015) Zhentao Guo et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Renoprotective effect of berberine on type 2 diabetic nephropathy in rats

(2015) Si-Fan Sun et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in rats

(2015) Wei-Jian Ni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tanshinone IIA attenuates renal fibrosis and inflammation via altering expression of TGF-β/Smad and NF-κB signaling pathway in 5/6 nephrectomized rats

(2015) Dong-Tao Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Association of prescribed Chinese herbal medicine use with risk of end-stage renal disease in patients with chronic kidney disease

(2015) Ming-Yen Lin et al.   KIDNEY INTERNATIONAL

Metabolite identification strategy of non-targeted metabolomics and its application for the identification of components in Chinese multicomponent medicine Abelmoschus manihot L.

(2015) Jian-ming Guo et al.   PHYTOMEDICINE

Renoprotective effects of berberine as adjuvant therapy for hypertensive patients with type 2 diabetes mellitus: Evaluation via biochemical markers and color Doppler ultrasonography

(2015) PEIFENG DAI et al.   Experimental and Therapeutic Medicine

Efficacy and Safety of Abelmoschus manihot for Primary Glomerular Disease: A Prospective, Multicenter Randomized Controlled Clinical Trial

(2014) Li Zhang et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Berberine ameliorates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats

(2014) Fang-Ming Wang et al.   NEPHROLOGY

Puerarin Attenuated Early Diabetic Kidney Injury through Down-Regulation of Matrix Metalloproteinase 9 in Streptozotocin-Induced Diabetic Rats

(2014) Yifei Zhong et al.   PLoS One

Tripterygium Preparations for the Treatment of CKD: A Systematic Review and Meta-analysis

(2013) Bin Zhu et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A

(2013) Chenchen Feng et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, ameliorates adriamycin-induced renal inflammation and glomerular injury via inhibiting p38MAPK signaling pathway activity in rats

(2013) Yue Tu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Therapeutic use of traditional Chinese herbal medications for chronic kidney diseases

(2013) Yifei Zhong et al.   KIDNEY INTERNATIONAL

Pretreatment with the Total Flavone Glycosides of Flos Abelmoschus manihot and Hyperoside Prevents Glomerular Podocyte Apoptosis in Streptozotocin-Induced Diabetic Nephropathy

(2012) Lei Zhou et al.   JOURNAL OF MEDICINAL FOOD

Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats

(2012) Feng Ling Wang et al.   MOLECULAR BIOLOGY REPORTS

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

(2011) Chan-Min Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Triptolide attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction

(2010) XIAO-PENG YUAN et al.   NEPHROLOGY

Effects of puerarin on receptor for advanced glycation end products in nephridial tissue of streptozotocin-induced diabetic rats

(2009) Jian Guo Shen et al.   MOLECULAR BIOLOGY REPORTS