Total Flavones of Abelmoschus manihot Remodels Gut Microbiota and Inhibits Microinflammation in Chronic Renal Failure Progression by Targeting Autophagy-Mediated Macrophage Polarization

Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

(2020) Xifan Wang et al.   GUT

Chemical constituents, clinical efficacy and molecular mechanisms of the ethanol extract of Abelmoschus manihot flowers in treatment of kidney diseases

(2020) Nan Li et al.   PHYTOTHERAPY RESEARCH

Representativeness of Randomized Clinical Trial Cohorts in End-stage Kidney Disease

(2019) Brendan Smyth et al.   JAMA Internal Medicine

Sedum sarmentosum Bunge extract alleviates inflammation and kidney injury via inhibition of M1-macrophage polarization

(2019) Hong Lu et al.   PHYTOMEDICINE

Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

(2018) Hong Lu et al.   BIOCHEMICAL PHARMACOLOGY

Gout: state of the art after a decade of developments

(2018) Tristan Pascart et al.   RHEUMATOLOGY

Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy

(2018) Wei Wu et al.   Frontiers in Pharmacology

Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats

(2018) Yiran Yu et al.   Frontiers in Microbiology

Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy

(2018) Buhui Liu et al.   Aging-US

Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis

(2018) Masateru Kondo et al.   AMERICAN JOURNAL OF HYPERTENSION

Huangkui capsule alleviates renal tubular epithelial-mesenchymal transition in diabetic nephropathy via inhibiting NLRP3 inflammasome activation and TLR4/NF-κB signaling

(2018) Wenbei Han et al.   PHYTOMEDICINE

MicrobiomeAnalyst: a web-based tool for comprehensive statistical, visual and meta-analysis of microbiome data

(2017) Achal Dhariwal et al.   NUCLEIC ACIDS RESEARCH

Total flavones of Abelmoschus manihot improve diabetic nephropathy by inhibiting the iRhom2/TACE signalling pathway activity in rats

(2017) Su Liu et al.   PHARMACEUTICAL BIOLOGY

Gut microbiome interactions with drug metabolism, efficacy, and toxicity

(2017) Ian D. Wilson et al.   Translational Research

Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling

(2017) Yue Tu et al.   Scientific Reports

Autophagy in kidney disease and aging: lessons from rodent models

(2016) Olivia Lenoir et al.   KIDNEY INTERNATIONAL

Therapeutics targeting persistent inflammation in chronic kidney disease

(2016) Anna Machowska et al.   Translational Research

Linking the Microbiota, Chronic Disease, and the Immune System

(2016) Timothy W. Hand et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota

(2016) Jumpei Sasabe et al.   Nature Microbiology

MTOR, PIK3C3, and autophagy: Signaling the beginning from the end

(2015) Michael J Munson et al.   Autophagy

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

(2015) Kun Liu et al.   Autophagy

Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial

(2015) Kenichi Tanaka et al.   Clinical and Experimental Nephrology

Altered intestinal microbial flora and impaired epithelial barrier structure and function in CKD: the nature, mechanisms, consequences and potential treatment

(2015) Nosratola D. Vaziri et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Efficacy and Safety of Abelmoschus manihot for Primary Glomerular Disease: A Prospective, Multicenter Randomized Controlled Clinical Trial

(2014) Li Zhang et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Dahuang Fuzi Decoction ameliorates tubular epithelial apoptosis and renal damage via inhibiting TGF-β1-JNK signaling pathway activation in vivo

(2014) Yue Tu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Macrophage heterogeneity, phenotypes, and roles in renal fibrosis

(2014) Qi Cao et al.   Kidney International Supplements

The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease

(2013) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Regulation of lipid accumulation by AMK-activated kinase in high fat diet–induced kidney injury

(2013) Anne-Emilie Declèves et al.   KIDNEY INTERNATIONAL

Macrophage-Induced Tumor Angiogenesis Is Regulated by the TSC2-mTOR Pathway

(2012) W. Chen et al.   CANCER RESEARCH

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Anti-hyperuricemic and nephroprotective effects of Smilax china L.

(2011) Lvyi Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Macrophages in Renal Disease

(2011) Y. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Levels of d-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice

(2011) Mao Horio et al.   NEUROCHEMISTRY INTERNATIONAL

Simultaneous two-dimensional HPLC determination of free d-serine and d-alanine in the brain and periphery of mutant rats lacking d-amino-acid oxidase

(2010) Yurika Miyoshi et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA