Total flavones of Abelmoschus manihot improve diabetic nephropathy by inhibiting the iRhom2/TACE signalling pathway activity in rats

Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, improves diabetic nephropathy via activating peroxisome proliferator–activated receptor (PPAR)-α/γ and attenuating endoplasmic reticulum stress in rats

(2016) Jing Ge et al.   JOURNAL OF ETHNOPHARMACOLOGY

ER stress inducer tunicamycin suppresses the self-renewal of glioma-initiating cell partly through inhibiting Sox2 translation

(2016) Yang Xing et al.   Oncotarget

Therapeutic strategies of diabetic nephropathy: recent progress and future perspectives

(2015) Meng Lv et al.   DRUG DISCOVERY TODAY

Nuclear versus cytosolic activity of the yeast Hog1 MAP kinase in response to osmotic and tunicamycin-induced ER stress

(2015) Sara García-Marqués et al.   FEBS LETTERS

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Inflammatory Cytokines in Diabetic Nephropathy

(2015) Javier Donate-Correa et al.   Journal of Diabetes Research

Definition, Classification and Diagnosis of Diabetes Mellitus

(2014) W. Kerner et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Lumbrokinase attenuates diabetic nephropathy through regulating extracellular matrix degradation in Streptozotocin-induced diabetic rats

(2013) Huili Sun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, ameliorates adriamycin-induced renal inflammation and glomerular injury via inhibiting p38MAPK signaling pathway activity in rats

(2013) Yue Tu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Diabetes: a 21st century challenge

(2013) Paul Z Zimmet et al.   Lancet Diabetes & Endocrinology

Treating diabetic nephropathy—still an unresolved issue

(2012) Mark E. Cooper   Nature Reviews Endocrinology

Are PPAR alpha agonists a rational therapeutic strategy for preventing abnormalities of the diabetic kidney?

(2012) Pitchai Balakumar et al.   PHARMACOLOGICAL RESEARCH

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Mitochondrial Dysfunction Mediates Aldosterone-Induced Podocyte Damage

(2011) Chunhua Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Beneficial effect of myricetin on renal functions in streptozotocin-induced diabetes

(2011) Filiz Ozcan et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Effects of HuangKui capsules on glibenclamide pharmacokinetics in rats

(2011) Zixiu Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Role of MicroRNA-214-Targeting Phosphatase and Tensin Homolog in Advanced Glycation End Product-Induced Apoptosis Delay in Monocytes

(2011) L.-M. Li et al.   JOURNAL OF IMMUNOLOGY

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Treatment of Metabolic Syndrome Slows Progression of Diabetic Nephropathy

(2011) Edgar G. Duran-Perez et al.   Metabolic Syndrome and Related Disorders

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Identification of the potential active components of Abelmoschus manihot in rat blood and kidney tissue by microdialysis combined with ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

(2010) Caifu Xue et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Diabetic kidney disease: act now or pay later

(2010) Robert C. Atkins et al.   KIDNEY INTERNATIONAL

Protective Effect of Total Flavones ofAbelmoschus manihotL. Medic Against Poststroke Depression Injury in Mice and Its Action Mechanism

(2009) Mei Liu et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

(2007) Daniel Tracey et al.   PHARMACOLOGY & THERAPEUTICS