Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1–Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway

Silencing of KCNQ1OT1 Decreases Oxidative Stress and Pyroptosis of Renal Tubular Epithelial Cells

(2020) Bei Zhu et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Salvianolic acid B attenuates epithelial-mesenchymal transition in renal fibrosis rats through activating Sirt1-mediated autophagy

(2020) Yu He et al.   BIOMEDICINE & PHARMACOTHERAPY

STAT5a induces endotoxin tolerance by alleviating pyroptosis in kupffer cells

(2020) Tao Wang et al.   MOLECULAR IMMUNOLOGY

Salvianolic Acid B Improves Chronic Mild Stress-Induced Depressive Behaviors in Rats: Involvement of AMPK/SIRT1 Signaling Pathway

(2020) Dehua Liao et al.   Journal of Inflammation Research

Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes

(2019) Zhen Qiu et al.   Journal of Diabetes Research

Maresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/ NF-κB pathways and activation of the Nrf2 pathway

(2019) Yun Qiu et al.   Drug Design Development and Therapy

β-hydroxybutyrate attenuates renal ischemia-reperfusion injury through its anti-pyroptotic effects

(2019) Takaya Tajima et al.   KIDNEY INTERNATIONAL

Macrophage Death as a Pharmacological Target in Atherosclerosis

(2019) Wim Martinet et al.   Frontiers in Pharmacology

Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury

(2019) Alfonso Rubio-Navarro et al.   Frontiers in Pharmacology

Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress

(2019) Hao Liu et al.   Redox Biology

A Melanin‐Based Natural Antioxidant Defense Nanosystem for Theranostic Application in Acute Kidney Injury

(2019) Tuanwei Sun et al.   ADVANCED FUNCTIONAL MATERIALS

Gastrodin ameliorates microvascular reperfusion injury–induced pyroptosis by regulating the NLRP3/caspase-1 pathway

(2019) Wenjing Sun et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway

(2019) Weixiang Xu et al.   Toxins

TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease

(2019) Youliang Wang et al.   Frontiers in Endocrinology

Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease

(2019) Michiko Tsushima et al.   ARCHIVES OF PHARMACAL RESEARCH

Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury

(2019) Yuting Jin et al.   Cellular & Molecular Immunology

Molecular Mechanisms of the Acute Kidney Injury to Chronic Kidney Disease Transition: An Updated View

(2019) Francesco Guzzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HIV-2 Depletes CD4 T Cells through Pyroptosis despite Vpx-Dependent Degradation of SAMHD1

(2019) Xiaoyu Luo et al.   JOURNAL OF VIROLOGY

Reappraising the spectrum of AKI and hepatorenal syndrome in patients with cirrhosis

(2019) Juan Carlos Q. Velez et al.   Nature Reviews Nephrology

Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation

(2019) Chang Jia et al.   Cell Death & Disease

Inhibition of gap junction composed of Cx43 prevents against acute kidney injury following liver transplantation

(2019) Dongdong Yuan et al.   Cell Death & Disease

Inflammation in Renal Diseases: New and Old Players

(2019) Vinicius Andrade-Oliveira et al.   Frontiers in Pharmacology

Pharmacological Inhibitors of the NLRP3 Inflammasome

(2019) Ayesha Zahid et al.   Frontiers in Immunology

The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney

(2019) Yang Gyun Kim et al.   Cells

Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases

(2019) Zoltan Ungvari et al.   GeroScience

Complement C1q synergizes with PTX3 in promoting NLRP3 inflammasome over-activation and pyroptosis in rheumatoid arthritis

(2019) Xun-yao Wu et al.   JOURNAL OF AUTOIMMUNITY

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis

(2018) Chun-Yan Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2

(2018) Miao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol Alleviates Inflammatory Responses and Oxidative Stress in Rat Kidney Ischemia-Reperfusion Injury and H2O2-Induced NRK-52E Cells via the Nrf2/TLR4/NF-κB Pathway

(2018) Jiawei Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2- and SIRT1-dependent pathways

(2018) Xiangsheng Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

mROS-TXNIP axis activates NLRP3 inflammasome to mediate renal injury during ischemic AKI

(2018) Yi Wen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo

(2018) Wei Liu et al.   Journal of Neuroinflammation

Repression of TXNIP-NLRP3 axis restores intestinal barrier function via inhibition of myeloperoxidase activity and oxidative stress in nonalcoholic steatohepatitis

(2018) Ru-Xue Bai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Salvianolic acid B abolished chronic mild stress‐induced depression through suppressing oxidative stress and neuro‐inflammation via regulating NLRP3 inflammasome activation

(2018) Qiaoting Huang et al.   JOURNAL OF FOOD BIOCHEMISTRY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats

(2017) Ning Zhang et al.   TOXICOLOGY LETTERS

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

Salvianolic acid B attenuates lipopolysaccharide-induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation

(2017) Da-Hai Zhao et al.   Experimental and Therapeutic Medicine

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

(2017) Katharina S. Schneider et al.   Cell Reports

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Salvianolic Acid B Ameliorates Hyperglycemia and Dyslipidemia in db/db Mice through the AMPK Pathway

(2016) Ming-Qing Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis

(2016) Ine Jorgensen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

(2016) Ine Jorgensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury

(2016) Jesper Kers et al.   SEMINARS IN NEPHROLOGY

Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling

(2016) Bin Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy

(2016) Khurrum Shahzad et al.   Scientific Reports

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

(2015) Lucia de Almeida et al.   IMMUNITY

Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+Efflux

(2015) Mausita Karmakar et al.   JOURNAL OF IMMUNOLOGY

Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps

(2015) H. Rabb et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Pathophysiology of ischaemic acute kidney injury

(2015) Nigel Suren Kanagasundaram   ANNALS OF CLINICAL BIOCHEMISTRY

Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways

(2014) Yubo Tang et al.   BIOCHEMICAL PHARMACOLOGY

Regulated Cell Death in AKI

(2014) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Noncanonical dendritic cell differentiation and survival driven by a bacteremic pathogen

(2013) Brodie Miles et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS