Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state

Structural insights into integrin α5β1 opening by fibronectin ligand

(2021) Stephanie Schumacher et al.   Science Advances

High integrin αVβ6affinity reached by hybrid domain deletion slows ligand-binding on-rate

(2018) Xianchi Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measuring Integrin Conformational Change on the Cell Surface with Super-Resolution Microscopy

(2018) Travis I. Moore et al.   Cell Reports

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Energy landscape differences among integrins establish the framework for understanding activation

(2017) Jing Li et al.   JOURNAL OF CELL BIOLOGY

Force interacts with macromolecular structure in activation of TGF-β

(2017) Xianchi Dong et al.   NATURE

Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions

(2017) Vinay Swaminathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin extension enables ultrasensitive regulation by cytoskeletal force

(2017) Jing Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

(2017) Pontus Nordenfelt et al.   Nature Communications

Ligand-induced Epitope Masking

(2016) A. Paul Mould et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

(2016) Brian T. DeVree et al.   NATURE

Integrins in synapse regulation

(2016) Yun Kyung Park et al.   NATURE REVIEWS NEUROSCIENCE

Relating conformation to function in integrin α5β1

(2016) Yang Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordinated integrin activation by actin-dependent force during T-cell migration

(2016) Pontus Nordenfelt et al.   Nature Communications

Regulation of integrin-mediated adhesions

(2015) Daniel V Iwamoto et al.   CURRENT OPINION IN CELL BIOLOGY

Inactive conformation enhances binding function in physiological conditions

(2015) Olga Yakovenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of integrin–fibronectin complexes by allosteric but not ligand-mimetic inhibitors

(2014) A. Paul Mould et al.   BIOCHEMICAL JOURNAL

Metal ion and ligand binding of integrin α5β1

(2014) Wei Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

(2013) Hui Wei et al.   DRUG DISCOVERY TODAY

How Natalizumab Binds and Antagonizes α4Integrins

(2013) Yamei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete integrin headpiece opening in eight steps

(2013) Jieqing Zhu et al.   JOURNAL OF CELL BIOLOGY

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

Application of Bio-Layer Interferometry for the analysis of protein/liposome interactions

(2012) Jakob Wallner et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

Regulation of integrin affinity on cell surfaces

(2011) Thomas Schürpf et al.   EMBO JOURNAL

The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling

(2009) Tong-Lay Lau et al.   EMBO JOURNAL

Mechanisms that regulate adaptor binding to  -integrin cytoplasmic tails

(2009) K. R. Legate et al.   JOURNAL OF CELL SCIENCE

The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3

(2009) Jieqing Zhu et al.   MOLECULAR CELL

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

Electrostatic rate enhancement and transient complex of protein–protein association

(2007) Ramzi Alsallaq et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS