Disruption of integrin–fibronectin complexes by allosteric but not ligand-mimetic inhibitors

What have we learned from trials on antiangiogenic agents in glioblastoma?

(2014) Riccardo Soffietti et al.   Expert Review of Neurotherapeutics

Atomic Basis for the Species-specific Inhibition of αV Integrins by Monoclonal Antibody 17E6 Is Revealed by the Crystal Structure of αVβ3 Ectodomain-17E6 Fab Complex

(2014) Bhuvaneshwari Mahalingam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strategies To Inhibit Tumor Associated Integrin Receptors: Rationale for Dual and Multi-Antagonists

(2014) Helen M. Sheldrake et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

(2014) Roger Stupp et al.   LANCET ONCOLOGY

Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes

(2014) S. Chakrabarti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Macrocycles As Highly Active Integrin α2β1 Antagonists

(2014) Nis Halland et al.   ACS Medicinal Chemistry Letters

Integrin modulators: a patent review

(2013) Tobias G Kapp et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Complete integrin headpiece opening in eight steps

(2013) Jieqing Zhu et al.   JOURNAL OF CELL BIOLOGY

Modulation of integrin activation and signaling by α1/α1′-helix unbending at the junction

(2013) Chuanmei Zhang et al.   JOURNAL OF CELL SCIENCE

Cyclic Mechanical Reinforcement of Integrin–Ligand Interactions

(2013) Fang Kong et al.   MOLECULAR CELL

Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin

(2013) D. I. Kisiela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development and validation of competition binding assays for affinity to the extracellular matrix receptors, αvβ3 and αIIbβ3 integrin

(2012) Alexander M. Szabo et al.   ANALYTICAL BIOCHEMISTRY

Molecular Dynamics Reveal that isoDGR-Containing Cyclopeptides Are True αvβ3 Antagonists Unable To Promote Integrin Allostery and Activation

(2012) Michela Ghitti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The role of β3-integrins in tumor angiogenesis: context is everything

(2011) Stephen D Robinson et al.   CURRENT OPINION IN CELL BIOLOGY

Mutagenesis studies of the β I domain metal ion binding sites on integrin αVβ3 ligand binding affinity

(2011) Joel Raborn et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Closed headpiece of integrin  IIb 3 and its complex with an  IIb 3-specific antagonist that does not induce opening

(2010) J. Zhu et al.   BLOOD

Structural Requirements for Activation in αIIbβ3 Integrin

(2010) Tetsuji Kamata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Mapping the ligand-binding pocket of integrin α5β1 using a gain-of-function approach

(2009) A. Paul Mould et al.   BIOCHEMICAL JOURNAL

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Linking integrin conformation to function

(2009) J. A. Askari et al.   JOURNAL OF CELL SCIENCE

Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcγRIIa and the integrin β3 cytoplasmic domain

(2009) Cunji Gao et al.   JOURNAL OF CLINICAL INVESTIGATION

Parallel kinetic analysis and affinity determination of hundreds of monoclonal antibodies using the ProteOn XPR36

(2008) Oded Nahshol et al.   ANALYTICAL BIOCHEMISTRY

Distinct Roles of β1 Metal Ion-dependent Adhesion Site (MIDAS), Adjacent to MIDAS (ADMIDAS), and Ligand-associated Metal-binding Site (LIMBS) Cation-binding Sites in Ligand Recognition by Integrin α2β1

(2008) Dimitra Valdramidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

Selected-fit versus induced-fit protein binding: Kinetic differences and mutational analysis

(2008) Thomas R. Weikl et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug

(2008) S. C. Khojasteh et al.   XENOBIOTICA