Nrf2 protects stellate cells from Smad-dependent cell activation

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis

(2017) Vincenzo Prestigiacomo et al.   PLoS One

Keap1-Nrf2 Interaction Suppresses Cell Motility in Lung Adenocarcinomas by Targeting the S100P Protein

(2015) M.-H. Chien et al.   CLINICAL CANCER RESEARCH

Roles of Nrf2 in cell proliferation and differentiation

(2015) Shohei Murakami et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

(2015) Rowena L. C. Sison-Young et al.   TOXICOLOGICAL SCIENCES

Activation of TGF-β1-CD147 positive feedback loop in hepatic stellate cells promotes liver fibrosis

(2015) Hai-Yan Li et al.   Scientific Reports

Human cell dedifferentiation in mesenchymal condensates through controlled autophagy

(2015) Rebecca Pennock et al.   Scientific Reports

MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis

(2014) Jing-Jing Yang et al.   CELLULAR SIGNALLING

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitory Role of the KEAP1-NRF2 Pathway in TGFβ1-Stimulated Renal Epithelial Transition to Fibroblastic Cells: A Modulatory Effect on SMAD Signaling

(2014) In-geun Ryoo et al.   PLoS One

Blockage of Nrf2 suppresses the migration and invasion of esophageal squamous cell carcinoma cells in hypoxic microenvironment

(2013) H. Shen et al.   DISEASES OF THE ESOPHAGUS

Transforming Growth Factor-β Induces Transcription Factors MafK and Bach1 to Suppress Expression of the Heme Oxygenase-1 Gene

(2013) Yukari Okita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Factor Erythroid 2-Related Factor 2 Nuclear Translocation Induces Myofibroblastic Dedifferentiation in Idiopathic Pulmonary Fibrosis

(2012) Elise Artaud-Macari et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2: A Potential Target for New Therapeutics in Liver Disease

(2012) A M Bataille et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling

(2011) Chang Joo Oh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fibromodulin, an Oxidative Stress-Sensitive Proteoglycan, Regulates the Fibrogenic Response to Liver Injury in Mice

(2011) Elisabetta Mormone et al.   GASTROENTEROLOGY

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Increased cell migration and plasticity in Nrf2-deficient cancer cell lines

(2010) G Rachakonda et al.   ONCOGENE

Regulation of Notch1 Signaling by Nrf2: Implications for Tissue Regeneration

(2010) N. Wakabayashi et al.   Science Signaling

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming growth factor-β1elicits Nrf2-mediated antioxidant responses in aortic smooth muscle cells

(2009) Adrian T. Churchman et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2 Related Factor 2 (Nrf2) Regulated Stress Pathway

(2008) S. L. Brown et al.   CANCER RESEARCH

Nuclear Factor-Eythroid 2–Related Factor 2 Prevents Alcohol-Induced Fulminant Liver Injury

(2008) Jutta Lamlé et al.   GASTROENTEROLOGY

The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis

(2008) Weihua Xu et al.   LABORATORY INVESTIGATION

Phosphatidylinositol 3-kinase/Akt pathway regulates hepatic stellate cell apoptosis

(2008) Yan Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY