Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells

α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease

(2020) Cecilia S. Lindestam Arlehamn et al.   Nature Communications

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids

(2020) María José Pérez et al.   MOLECULAR PSYCHIATRY

Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation

(2020) Dipen Rajgor et al.   Cell Reports

Immune Signaling in Neurodegeneration

(2019) Timothy R. Hammond et al.   IMMUNITY

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo

(2018) Elena Kozina et al.   BRAIN

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease

(2018) Annika Sommer et al.   Cell Stem Cell

Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients

(2018) Natasa Kustrimovic et al.   Journal of Neuroinflammation

Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

(2018) Feilong Wang et al.   EBioMedicine

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Functional and behavioral consequences of Parkinson's disease-associated LRRK2-G2019S mutation

(2018) Deanna L. Benson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of LRRK2 in cytoskeletal dynamics

(2018) Laura Civiero et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

(2018) Joanna A. Korecka et al.   Stem Cell Reports

Type I interferon pathway in CNS homeostasis and neurological disorders

(2017) Thomas Blank et al.   GLIA

Extracting microtubule networks from superresolution single-molecule localization microscopy data

(2017) Zhen Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization

(2017) Sonia Agüera-González et al.   Cell Reports

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

(2017) Walther Haenseler et al.   Stem Cell Reports

Store-Operated Ca 2+ Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity

(2016) Martin Vaeth et al.   IMMUNITY

Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons

(2016) Rakel López de Maturana et al.   Journal of Neuroinflammation

Inflammatory profile in LRRK2-associated prodromal and clinical PD

(2016) Kathrin Brockmann et al.   Journal of Neuroinflammation

Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology

(2016) Aleksandra Deczkowska et al.   TRENDS IN IMMUNOLOGY

I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway

(2015) Etsuro Ohta et al.   HUMAN MOLECULAR GENETICS

Ca2+Signaling but Not Store-Operated Ca2+Entry Is Required for the Function of Macrophages and Dendritic Cells

(2015) Martin Vaeth et al.   JOURNAL OF IMMUNOLOGY

Immune aging, dysmetabolism, and inflammation in neurological diseases

(2015) Michela Deleidi et al.   Frontiers in Neuroscience

Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival

(2014) Chia-Lung Chuang et al.   HUMAN MOLECULAR GENETICS

Interferon-γ induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages

(2014) Martin Kuss et al.   JOURNAL OF NEUROCHEMISTRY

Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson’s Disease

(2014) Noa Liscovitch et al.   PLoS One

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

(2014) Carolina Cebrián et al.   Nature Communications

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

Microglial Phenotype Is Regulated by Activity of the Transcription Factor, NFAT (Nuclear Factor of Activated T Cells)

(2013) K. Nagamoto-Combs et al.   JOURNAL OF NEUROSCIENCE

Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

(2013) Peter Reinhardt et al.   PLoS One

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity

(2012) F. Gillardon et al.   NEUROSCIENCE

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: Impairment of the kinase activity by Parkinson's disease-associated mutations

(2011) Etsuro Ohta et al.   FEBS LETTERS

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

(2011) Mansoureh Hakimi et al.   JOURNAL OF NEURAL TRANSMISSION

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

(2011) Claudio Mauro et al.   NATURE CELL BIOLOGY

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification

(2011) Paramita Chakrabarty et al.   NATURE NEUROSCIENCE

Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation

(2011) Jonathan Thévenet et al.   PLoS One

Calcineurin regulates innate antifungal immunity in neutrophils

(2010) Matthew B. Greenblatt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

(2010) B. Winner et al.   NEUROBIOLOGY OF DISEASE

Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex

(2009) Cynthia K. Shrum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcineurin/NFAT Signaling Is Required for Neuregulin-Regulated Schwann Cell Differentiation

(2009) S.-C. Kao et al.   SCIENCE

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS