Article
Neurosciences
Hildur Soley Sveinsdottir, Christian Christensen, Haraldur Porsteinsson, Perrine Lavalou, Matthew O. Parker, Alena Shkumatava, William H. J. Norton, Emile Andriambeloson, Stephanie Wagner, Karl Aegir Karlsson
Summary: This study established a genetic model of ADHD in zebrafish and identified five potential non-stimulant therapeutic options. These findings provide a new tool for understanding the neural circuits and etiology of ADHD, and also discover novel treatment options.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anahit Mkrtchian, Jennifer W. Evans, Christoph Kraus, Peixiong Yuan, Bashkim Kadriu, Allison C. Nugent, Jonathan P. Roiser, Carlos A. Zarate
Summary: Ketamine improved motivational symptoms in patients with treatment-resistant major depressive disorder by normalizing fronto-striatal connectivity, while disrupting this connectivity in healthy volunteers, regardless of inflammatory processes.
MOLECULAR PSYCHIATRY
(2021)
Review
Psychiatry
Rose L. Tong, Ubaidah N. Kahn, Laura A. Grafe, Frederick L. Hitti, Nathan T. Fried, Brian F. Corbett
Summary: Inflammatory processes are increased by stress, specifically through noradrenergic neurotransmission. Glucocorticoid signaling usually counters these pro-inflammatory effects but is impaired in chronically stressed individuals. This review focuses on the mechanisms by which chronic stress increases inflammation through noradrenergic signaling and its contribution to stress-related mood disorders, aiming to provide insights for future therapeutic strategies.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Kaiwen Xi, Haoxiang Xiao, Xin Huang, Ziduo Yuan, Mingyue Liu, Honghui Mao, Haiying Liu, Guaiguai Ma, Zishuo Cheng, Yuqiao Xie, Yang Liu, Dayun Feng, Wenting Wang, Baolin Guo, Shengxi Wu
Summary: Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disease characterized by severe defensive behaviors. This study found that the overactivation of the higher-order thalamus, PoM, played a role in excessive defensiveness in a mouse model of PTSD. The dysfunction of thalamic inhibition and excessive thalamic innervation to the frontal association cortex were identified as the underlying mechanisms. These findings suggest that targeting the thalamocortical circuit may be a potential treatment for overreactivity symptoms in PTSD.
Review
Neurosciences
Yi-Qun Wang, Wen-Ying Liu, Lei Li, Wei-Min Qu, Zhi-Li Huang
Summary: REM sleep is believed to be associated with dreaming, but the mechanisms of its generation are still unclear. Several models have been established to explain REM sleep. REM sleep behavior disorder and narcolepsy are two common disorders related to REM sleep.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Psychiatry
Sixiang Liang, Xinyu Liu, Dan Li, Jinhe Zhang, Guangwei Zhao, Hongye Yu, Xixi Zhao, Sha Sha
Summary: This study aims to explore the risk factors associated with suicidal behavior and establish predictive models in female patients with mood disorders using LASSO regression. A cross-sectional survey was conducted among 396 female individuals diagnosed with mood disorders. Logistic LASSO regression analyses were used to identify risk factors and a nomogram was constructed to develop a prediction model. The accuracy of the model was evaluated using a ROC curve.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Frank Faltraco, Denise Palm, Andrew Coogan, Frederick Simon, Oliver Tucha, Johannes Thome
Summary: This review summarizes the current knowledge and literature on circadian rhythms in the context of mood disorders, with a focus on the role of circadian genes, hormones, and neurotransmitters. The study suggests a molecular link between disruptions in the circadian rhythm and mood disorders, often leading to clinical symptoms resembling depression.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Neurosciences
Yufei Liu, Long Niu, Xinyao Liu, Cheng Cheng, Weidong Le
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by both motor and non-motor symptoms, with circadian rhythm dysregulation emerging as a key feature that may play a pivotal role in the pathogenesis of PD. Recent research progress has focused on understanding altered circadian rhythm in PD, from clinical manifestations to underlying causes of circadian disorders in PD.
NEUROSCIENCE BULLETIN
(2021)
Article
Psychiatry
Parisa Vidafar, Anastasia K. Yocum, Peisong Han, Melvin G. McInnis, Helen J. Burgess
Summary: This study found that individuals with a late chronotype were more likely to experience depressive symptoms over a 5-year period, even after adjusting for age, sex, and baseline mood. Late chronotypes also reported fewer hypomania/mania episodes during the follow up. These results suggest that circadian phase advancing treatments should be explored as a means to reduce depressive symptoms in late chronotypes with bipolar disorder.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2021)
Article
Behavioral Sciences
Melissa E. S. Richardson, Desiree Brown, Danielle Honore, Andisa Labossiere
Summary: This study showed that fragmenting the night period and distributing it across the 24-hour day resulted in lengthening of circadian rhythm in mice, leading to reduced anxiety and anhedonia behaviors. However, these effects were reversible after exposure to the fragmented night cycle for a period of time.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Rebecca Drachman, Lejla Colic, Anjali Sankar, Linda Spencer, Danielle A. Goldman, Luca M. Villa, Jihoon A. Kim, Maria A. Oquendo, Brian Pittman, Hilary P. Blumberg
Summary: This study aimed to investigate the brain-based distinctions between aggression and impulsivity in Bipolar Disorder (BD) and their associations with risk factors, symptoms, and suicide thoughts and behaviors. The findings revealed elevated aggression and impulsivity in BD, which were associated with childhood maltreatment, depression, substance use disorders, and suicide attempts. The study suggests that these behavioral constructs are associated with specific brain regions and can be targeted for prevention.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Ryan W. Logan, Angela R. Ozburn, Rachel N. Arey, Kyle D. Ketchesin, Alicia Winquist, Andrew Crain, Brian T. D. Tobe, Darius Becker-Krail, Matthew B. Jarpe, Xiangning Xue, Wei Zong, Zhiguang Huo, Puja K. Parekh, Xiyu Zhu, Ethan Fitzgerald, Hui Zhang, Jeffrey Oliver-Smith, Lauren M. DePoy, Mariah A. Hildebrand, Evan Y. Snyder, George C. Tseng, Colleen A. McClung
Summary: This study identified that inhibiting histone deacetylase proteins (HDACs) especially HDAC2 can effectively treat bipolar mania, providing guidance for the development of novel therapeutic drugs.
MOLECULAR PSYCHIATRY
(2021)
Article
Cell Biology
Shenghuan Sun, Justin Torok, Christopher Mezias, Daren Ma, Ashish Raj
Summary: This study utilizes machine learning to model the relationship between cell type composition and connectivity, demonstrating a link between cell types and connectivity in both long-range and short-range connections.
Article
Clinical Neurology
Hongliang Feng, Amy Wing -Yin Ho, Binbin Lei, Joey Wing Yan Chan, Jing Wang, Yaping Liu, Jessie Chi Ching Tsang, Ngan Yin Chan, Siu Ping Lam, Kathleen Ries Merikangas, Chung Shun Ho, Jihui Zhang, Yun Kwok Wing
Summary: This study found that unaffected offspring of parents with bipolar disorder already exhibited circadian rhythm dysregulation, with lower nocturnal melatonin levels, smaller melatonin AUC within two hours after DLMO, and larger phase angle between DLMO and sleep onset compared to offspring of control parents.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Behavioral Sciences
Joanne S. Carpenter, Jacob J. Crouse, Elizabeth M. Scott, Sharon L. Naismith, Chloe Wilson, Jan Scott, Kathleen R. Merikangas, Ian B. Hickie
Summary: Major mood syndromes are common and disabling mental disorders, with a lack of clear delineation of underlying pathophysiological mechanisms hindering prevention and treatment. Dysfunction of the 24-h circadian system is a potential mechanism linked to mood syndromes. 'Circadian depression' is proposed as a new clinical phenotype with disrupted 24-h sleep-wake cycles, reduced motor activity, low subjective energy, and weight gain as key characteristics. Early onset, bipolarity features, poor response to traditional antidepressants, and concurrent cardiometabolic and inflammatory issues are part of the illness course associated with this phenotype. Identifying and targeting circadian disturbances in mood syndromes may offer valuable clinical insights for effective treatment strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Hiroko Kotajima-Murakami, Hideo Hagihara, Atsushi Sato, Yoko Hagino, Miho Tanaka, Yoshihisa Katoh, Yasumasa Nishito, Yukio Takamatsu, Shigeo Uchino, Tsuyoshi Miyakawa, Kazutaka Ikeda
Summary: This study found that exposure to the GABA(A) receptor antagonist picrotoxin during the embryonic period induced ASD-like behavior in mice. The offspring exhibited a reduction in active interaction time in social interaction tests, and gene expression analysis showed an increase in odorant receptor gene expression. The findings suggest that impaired odorant function may contribute to social deficits in individuals with ASD.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Takafumi Kawai, Hirotaka Narita, Kohtarou Konno, Sharmin Akter, Rizki Tsari Andriani, Hirohide Iwasaki, Shoji Nishikawa, Norihiko Yokoi, Yuko Fukata, Masaki Fukata, Pattama Wiriyasermkul, Pornparn Kongpracha, Shushi Nagamori, Keizo Takao, Tsuyoshi Miyakawa, Manabu Abe, Kenji Sakimura, Masahiko Watanabe, Atsushi Nakagawa, Yasushi Okamura
Summary: Voltage-sensing protein TMEM266 has a unique voltage-sensing mechanism and interacts with specific splice variants. The coiled-coil region plays a significant role in forming homodimers, and the cytosolic region at the C-terminal of TMEM266 may bind to various targets. TMEM266 deficiency is associated with behavioral abnormalities.
BIOCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Katsuya Miyajima, Yusuke Sudo, Sho Sanechika, Yoshitaka Hara, Mieko Horiguchi, Feng Xu, Minori Suzuki, Satoshi Hara, Koichi Tanda, Ken-ichi Inoue, Masahiko Takada, Nozomu Yoshioka, Hirohide Takebayashi, Masayo Mori-Kojima, Masahiro Sugimoto, Chiho Sumi-Ichinose, Kazunao Kondo, Keizo Takao, Tsuyoshi Miyakawa, Hiroshi Ichinose
Summary: Increasing evidence suggests that peripheral amino acid metabolism is involved in the pathophysiology of neuropsychiatric disorders, but the molecular mechanisms are largely unknown. This study found that disturbances in tetrahydrobiopterin (BH4) metabolism can lead to hyperphenylalaninemia and monoamine deficiency in the brain, potentially contributing to the development of anxiety-related psychiatric disorders.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Neurosciences
Akiko Oota-Ishigaki, Keizo Takao, Daisuke Yamada, Masayuki Sekiguchi, Masayuki Itoh, Yumie Koshidata, Manabu Abe, Rie Natsume, Masaki Kaneko, Toma Adachi, Toshie Kaizuka, Nami Suzuki, Kenji Sakimura, Hiroyuki Okuno, Keiji Wada, Masayoshi Mishina, Tsuyoshi Miyakawa, Takashi Hayashi
Summary: This study suggests that impairment of AMPA receptor palmitoylation specifically causes symptoms resembling posttraumatic stress disorder (PTSD), including prolonged contextual fear memory formation and increased fear generalization. However, this mutation has no effect on anxiety levels, locomotion, sociability, depression-related behaviors, and spatial learning and memory.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Antonia Lilja, Giuliano Didio, Jongryul Hong, Won Do Heo, Eero Castren, Juzoh Umemori
Summary: This study validates the activation of highly sensitive optoTrkB (E281A) in the mouse visual cortex and demonstrates its potential for iPlasticity studies of both inhibitory and excitatory neurons in behavioral research through immunohistochemistry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Takayuki Mitsuhashi, Satoko Hattori, Kimino Fujimura, Shinsuke Shibata, Tsuyoshi Miyakawa, Takao Takahashi
Summary: Valproic acid (VPA) is an antiepileptic drug that inhibits epileptic activity of neurons mainly through sodium channel inhibition and GABA transaminase inhibition. It also inhibits histone deacetylases, leading to epigenetic modifications of stem/progenitor cell characteristics and affecting fetal development. Clinical studies have shown that VPA exposure in utero increases the risk of autistic features and intellectual disabilities in children. A study on mice revealed that in utero VPA exposure led to abnormal social interaction, cognitive changes, hypersensitivity to pain/heat, and impaired locomotor activity, resembling symptoms of autism spectrum disorder in humans.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Shohei Iida, Hirotaka Shoji, Fumihiro Kawakita, Takehisa Nakanishi, Yoshiaki Matsushima, Makoto Kondo, Koji Habe, Hidenori Suzuki, Tsuyoshi Miyakawa, Keiichi Yamanaka
Summary: Intense itching reduces the quality of life and is associated with psychiatric conditions. This study used a dermatitis mouse model to evaluate psychiatric symptoms and found that Lcn2 is closely associated with anxiety symptoms, but anxiety and depression caused by chronic skin inflammation may be irreversible. Active control of skin inflammation is essential for preventing anxiety.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Hirotaka Shoji, Kazutaka Ikeda, Tsuyoshi Miyakawa
Summary: This study investigated the effects of 5-HTT deficiency on behavior, gut microbiota, and brain c-Fos expression. The findings revealed abnormal behaviors including decreased locomotor activity, reduced pain sensitivity, increased anxiety and depression-related behavior, and altered gut microbiota composition in 5-HTT-/- mice. The expression of c-Fos in certain brain regions was also different from normal. These results indicate that 5-HTT-/- mice serve as a valid animal model to study anxiety and depression.
Article
Neurosciences
Mohamed Darwish, Satoko Hattori, Hirofumi Nishizono, Tsuyoshi Miyakawa, Nozomu Yachie, Keizo Takao
Summary: GlyR alpha 4 subunit is mainly expressed in the hindbrain and midbrain of mice, and has lower expression in other regions of the brain. The expression of GlyR alpha 4 increases during brain development. Mutant mice with Glra4 deficiency show changes in startle response, social behavior, and anxiety-like behavior.
Article
Psychiatry
Hideo Hagihara, Tomoyuki Murano, Tsuyoshi Miyakawa
Summary: The study suggests that changes in brain pH, expressed as pH, are associated with various neuropsychiatric disorders. The expression patterns of pH-associated genes in these disorders were analyzed in human patients and mouse models, showing abnormal expression levels. Furthermore, astrocytes were identified as the cell type with the highest acidity-related gene expression. These findings indicate that the expression pattern of pH-associated genes may serve as a surrogate for pH changes in brain cells and provide insights into the pathophysiology of neuropsychiatric disorders.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Yashuang Ping, Kenji Ohata, Kenji Kikushima, Takumi Sakamoto, Ariful Islam, Lili Xu, Hengsen Zhang, Bin Chen, Jing Yan, Fumihiro Eto, Chiho Nakane, Keizo Takao, Tsuyoshi Miyakawa, Katsuya Kabashima, Miho Watanabe, Tomoaki Kahyo, Ikuko Yao, Atsuo Fukuda, Koji Ikegami, Yoshiyuki Konishi, Mitsutoshi Setou
Summary: As an important neurotransmitter, glutamate functions in the majority of excitatory synapses in the human brain. The metabolic pathway of glutamate is complex, and the exact role of glutamate pool in neurons remains unclear. This study utilized Ttll1 and Ttll7 knockout mice to investigate the impact of tubulin polyglutamylation on neuronal behavior. Matrix-assisted laser desorption/ionization (MALDI) Imaging mass spectrometry (IMS) analysis revealed increased levels of glutamate in the brains of knockout mice, suggesting that tubulin polyglutamylation by TTLLs acts as a reservoir of glutamate in neurons and modulates other glutamate-related amino acids.
Article
Multidisciplinary Sciences
Katsutaka Oishi, Yuhei Yajima, Yuta Yoshida, Hideo Hagihara, Tsuyoshi Miyakawa, Sayaka Higo-Yamamoto, Atsushi Toyoda
Summary: Disordered sleep is a global social problem and a significant risk factor for psychological and metabolic diseases. Analysis of saliva metabolites in mouse models of chronic sleep disorder revealed significant changes in metabolic pathways related to glycine, serine, threonine, and glucose metabolism. These findings suggest that profiling salivary metabolites could be a useful strategy for diagnosing chronic sleep disorder.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Hirotaka Shoji, Hiroshi Kunugi, Tsuyoshi Miyakawa
Summary: This study investigated the acute and chronic effects of oral administration of capric acid (C10) on behavior in mice. The results showed that high doses of C10 decreased body weight, distance traveled, and increased anxiety-like behavior, while low doses of C10 increased distance traveled. Repeated administration of C10 at a high dose for more than 21 days led to lower body weight and decreased depression-related behavior.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2022)
Meeting Abstract
Ophthalmology
Chieko Koike, Tesshu Hori, Keishun Iwao, Shohei Ikuta, Satoko Hattori, Keizo Takao, Tsuyoshi Miyakawa
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Clinical Neurology
Masayoshi Nagai, Kenji Iemura, Takako Kikkawa, Sharmin Naher, Satoko Hattori, Hideo Hagihara, Koh-ichi Nagata, Hayato Anzawa, Risa Kugisaki, Hideki Wanibuchi, Takaya Abe, Kenichi Inoue, Kengo Kinoshita, Tsuyoshi Miyakawa, Noriko Osumi, Kozo Tanaka
Summary: The deficiency of CHAMP1 gene causes intellectual disability and is associated with delayed neuronal development and behavioral defects observed in mice models.
BRAIN COMMUNICATIONS
(2022)
