Article
Clinical Neurology
Shin Nabatame, Junpei Tanigawa, Koji Tominaga, Kuriko Kagitani-Shimono, Keiko Yanagihara, Katsumi Imai, Toru Ando, Yu Tsuyusaki, Nami Araya, Mayumi Matsufuji, Jun Natsume, Kotaro Yuge, Drago Bratkovic, Hiroshi Arai, Takeshi Okinaga, Takeshi Matsushige, Yoshiteru Azuma, Naoko Ishihara, Satoko Miyatake, Mitsuhiro Kato, Naomichi Matsumoto, Nobuhiko Okamoto, Satoru Takahashi, Satoshi Hattori, Keiichi Ozono
Summary: This study found that there is a significant association between cerebrospinal fluid glucose and glucose/blood glucose ratio with the severity of Glut1DS. Glucose and lactate are independent contributors to the developmental and neurological status in Glut1DS.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Critical Care Medicine
Yueyue Kong, Yi Ye, Jiawei Ma, Guangzhi Shi
Summary: This study found that cerebrospinal fluid heparin-binding protein (HBP) has a high diagnostic value in nosocomial meningitis and ventriculitis. Compared with lactate and procalcitonin, HBP has higher diagnostic accuracy and can assist in solving the diagnostic difficulties caused by empirical antibiotherapy.
Article
Clinical Neurology
Regina J. Faubel, Veronica S. Santos Canellas, Jenna Gaesser, Nancy H. Beluk, Tim N. Feinstein, Yong Wang, Maya Yankova, Kalyani B. Karunakaran, Stephen M. King, Madhavi K. Ganapathiraju, Cecilia W. Lo
Summary: This study reveals the association between abnormal motile cilia motion and flow pattern with epilepsy. These findings suggest that cilia regulating kinases may be potential therapeutic targets for medication-resistant epilepsy.
ACTA NEUROPATHOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Yuzhe Yang, Yuan Yuan, Guo Zhang, Hao Wang, Ying-Cong Chen, Yingcheng Liu, Christopher G. Tarolli, Daniel Crepeau, Jan Bukartyk, Mithri R. Junna, Aleksandar Videnovic, Terry D. Ellis, Melissa C. Lipford, Ray Dorsey, Dina Katabi
Summary: Parkinson's disease can be diagnosed and monitored based on breathing patterns during sleep using a neural network model. The model shows high accuracy in detecting PD and can also estimate severity and progression.
Article
Medicine, General & Internal
Louisa Nitsch, Stefan Felix Ehrentraut, Marcus Grobe-Einsler, Felix J. Bode, Mohammed Banat, Matthias Schneider, Felix Lehmann, Julian Zimmermann, Johannes Weller
Summary: Community-acquired bacterial meningitis is a serious disease that can lead to severe complications and death. This study investigated the diagnostic performance of cerebrospinal fluid (CSF) parameters for sepsis in patients with community-acquired bacterial meningitis.
Article
Clinical Neurology
Qin Wang, YongFang Wang, Yan Yang, YanXi Kong, Yuan Peng
Summary: This study aimed to investigate the value of cerebrospinal fluid lactate concentrations in post-neurosurgical bacterial meningitis. It was found that erythrocytes do not affect cerebrospinal fluid lactate, and elevated lactate concentrations can be used as a marker for postoperative bacterial meningitis.
Article
Biochemistry & Molecular Biology
Mario Stampanoni Bassi, Tommaso Nuzzo, Luana Gilio, Mattia Miroballo, Alessia Casamassa, Fabio Buttari, Paolo Bellantonio, Roberta Fantozzi, Giovanni Galifi, Roberto Furlan, Annamaria Finardi, Arianna De Rosa, Anna Di Maio, Francesco Errico, Diego Centonze, Alessandro Usiello
Summary: The study found that levels of cerebrospinal fluid L-glutamate (L-Glu) were slightly reduced in patients with multiple sclerosis, and were correlated with disability progression and inflammatory molecules like interleukin. Abnormal expression of L-Glu was associated with disability progression, oxidative stress, and inflammation.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Clinical Neurology
Olivia Grech, Senali Y. Seneviratne, Zerin Alimajstorovic, Andreas Yiangou, James L. Mitchell, Thomas B. Smith, Susan P. Mollan, Gareth G. Lavery, Christian Ludwig, Alexandra J. Sinclair
Summary: This study evaluated the metabolomic profile in individuals with idiopathic intracranial hypertension (IIH) and compared it with control group. The study found that individuals with IIH had lower urea levels, increased lactate:pyruvate ratio, higher baseline acetate levels, and altered ketone body metabolites in the cerebrospinal fluid. These metabolic disturbances normalized after therapeutic weight loss.
Article
Multidisciplinary Sciences
Kaili Shi, Xue Li, Ying Li, Xiaohua Tan, Kelu Zheng, Wenxiong Chen, Xiaojing Li
Summary: This study aimed to investigate the changes of peripheral blood glucose before and after lumbar puncture, and the results showed that it is unnecessary to measure blood glucose before lumbar puncture, especially for pediatric patients. From the perspective of facilitating smoother cerebrospinal fluid puncture in children, blood glucose measurement after lumbar puncture might be a better choice.
Review
Biochemistry & Molecular Biology
Ignacio Fernandez-Moncada, Rui S. Rodrigues, Unai B. Fundazuri, Luigi Bellocchio, Giovanni Marsicano
Summary: The brain requires a large amount of energy and has developed specialized mechanisms to control and fulfill its energy needs. The endocannabinoid system, particularly the CB1 receptor, plays a significant role in regulating brain functions and behavior. The mtCB1 receptors in neurons and astrocytes impair mitochondrial functions and specifically influence behavioral outputs. Understanding the potential implications of (mt)CB1 receptors on oligodendrocytes and microglia metabolic functions can provide insights into the role of these receptors in brain function and behavior.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Microbiology
Edwin Nuwagira, Kathy Huppler Hullsiek, Samuel Jjunju, Morris Rutakingirwa, John Kasibante, Kiiza Kandole Tadeo, Enock Kagimu, Lillian Tugume, Kenneth Ssebambulidde, Abdu K. Musubire, Ananta Bangdiwala, Conrad Muzoora, David B. Meya, David R. Boulware, Nathan C. Bahr, Fiona V. Creswell
Summary: This study evaluated the role of CSF lactate in diagnosing and predicting outcomes of TBM in HIV-positive individuals. High CSF lactate levels were found to be associated with the diagnosis of TBM, but not predictive of 2-week mortality. CSF lactate may be a useful tool in diagnosing TBM in the clinical setting.
MICROBIOLOGY SPECTRUM
(2022)
Article
Critical Care Medicine
Elisa Gouvea Bogossian, Chahnez Taleb, Raffaele Aspide, Rafael Badenes, Denise Battaglini, Federico Bilotta, Aaron Blandino Ortiz, Anselmo Caricato, Carlo Alberto Castioni, Giuseppe Citerio, Gioconda Ferraro, Costanza Martino, Isabella Melchionda, Federica Montanaro, Berta Monleon Lopez, Consolato Gianluca Nato, Michael Piagnerelli, Edoardo Picetti, Chiara Robba, Olivier Simonet, Aurelie Thooft, Fabio Silvio Taccone
Summary: This study aimed to assess the changes in cerebrospinal fluid glucose-to-lactate ratio (CGLR) related to therapies aimed at reducing intracranial pressure. The results showed that CGLR significantly changed over time, regardless of the study group, with a more significant effect in patients receiving interventions to reduce intracranial pressure.
Article
Endocrinology & Metabolism
Sivakama S. Bharathi, Bob B. Zhang, Eli Paul, Yuxun Zhang, Alexandra V. Schmidt, Benjamin Fowler, Yijen Wu, Michael Tiemeyer, Kei-ichiro Inamori, Jin-ichi Inokuchi, Eric S. Goetzman
Summary: GM3 synthase (GM3S) deficiency is a rare neurodevelopmental disorder that affects cell adhesion, growth, and receptor-mediated signal transduction. This study found that GM3S deficiency leads to metabolic changes, including increased whole-body respiration and glucose uptake in the brain, as well as alterations in mitochondrial function. These findings suggest that GM3S deficiency may contribute to a hypermetabolic phenotype and promote seizure activity.
MOLECULAR GENETICS AND METABOLISM
(2022)
Review
Medicine, General & Internal
Inga Zerr
Summary: The diagnosis of Creutzfeldt-Jakob disease has evolved to include the detection of 14-3-3 protein and abnormally folded prion protein in cerebrospinal fluid, with nearly 100% sensitivity and specificity.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Natalia Czarniak, Joanna Kaminska, Joanna Matowicka-Karna, Olga Martyna Koper-Lenkiewicz
Summary: Cerebrospinal fluid plays a crucial role in protecting the central nervous system by providing support, absorbing shocks, and transporting nutrients and waste products. This review provides an overview of cerebrospinal fluid history, production, circulation, main components, and the roles of blood-brain barrier and blood-cerebrospinal fluid barrier in maintaining homeostasis. The utility of Albumin Quotient evaluation in the diagnosis of CNS diseases is discussed. The importance of research on cerebrospinal fluid for improving disease management and discovering new treatment options is highlighted.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreia Rocha, Bruna Bellaver, Debora G. Souza, Guilherme Schu, Igor C. Fontana, Gianina T. Venturin, Samuel Greggio, Fernanda U. Fontella, Manoela L. Schiavenin, Luiza S. Machado, Diogo Miron, Jaderson C. da Costa, Pedro Rosa-Neto, Diogo O. Souza, Luc Pellerin, Eduardo R. Zimmer
Summary: This study used FDG-PET imaging to investigate the impact of the antipsychotic drug clozapine on brain glucose metabolism in rats, and found that downregulation of GLT-1 resulted in astrocyte-dependent cortical hypometabolism, resembling the hypometabolic signature observed in people developing dementia.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Public, Environmental & Occupational Health
Camila Dallazen, Daniela Cardoso Tietzmann, Sara Araujo da Silva, Eduardo Augusto Fernandes Nilson, Vivian Siqueira Santos Goncalves, Regina Maria Ferreira Lang, Sandra Patricia Crispim, Julia Dubois Moreira, Solange Cristina Garcia, Marcia Regina Vitolo
Summary: This study aimed to estimate the prevalence of vitamin A deficiency (VAD) in a poverty-stricken region of southern Brazil and identify associated risk factors. The results showed that VAD was not a public health problem for children in this region, with a prevalence rate of 1.9%. Risk factors associated with VAD included receiving benefits from the Bolsa Familia program, not being breastfed, and stunting. These findings suggest the need for continuous monitoring and improvement of public policies related to vitamin A supplementation in Brazil.
PUBLIC HEALTH NUTRITION
(2023)
Article
Critical Care Medicine
Wagner L. Nedel, Nathan R. Strogulski, Marcelo S. Rodolphi, Afonso Kopczynski, Tiago H. M. Montes, Luis V. Portela
Summary: This study investigates the association between mitochondrial respiratory states and inflammatory biomarkers in patients with septic shock. The results show that metabolic changes in mitochondrial complex I and complex II of lymphocytes are correlated with a decrease in IL-6 levels, indicating a decrease in overall inflammatory activity.
Article
Microbiology
Estela Mariana Guimaraes Lourenco, Juliana Fortes Di Iorio, Fernanda da Silva, Felipe Leonardo Bley Fialho, Melquisedeque Mateus Monteiro, Adilson Beatriz, Renata Trentin Perdomo, Euzebio Guimaraes Barbosa, Jean Pierre Oses, Carla Cardozo Pinto de Arruda, Wagner Alves de Souza Judice, Jamal Rafique, Denis Pires de Lima
Summary: Leishmaniasis, a neglected tropical disease that affects more than 350 million people globally, currently lacks a vaccine and faces challenges in treatment. A multitarget drug strategy using flavonoid compounds shows promising prospects. In this study, 17 flavonoid analogues were synthesized using a scalable, easy-to-reproduce, and inexpensive method, all of which exhibited impressive inhibition against target enzymes highly expressed in the parasite. Compounds 3c, f12a, and f12b showed effectiveness against all tested isoforms and had low cytotoxicity. These results represent a pioneering advancement in understanding the mechanism of action of flavonoid derivatives against leishmaniasis and hold promise for the development of cysteine protease inhibitors for treatment.
Article
Information Science & Library Science
Carolina Bittencourt Gomes, Luciana Calabro, Suzana Rachel de Oliveira, Leo Anderson Meira Martins, Diogo Onofre Souza, Ediane Maria Gheno
Summary: This article evaluated the characteristics of grantees in the Health Sciences area of the National Council for Scientific and Technological Development. Various indicators were used to assess 1,634 researchers with current grants in 2021. The study found differences in the distribution of articles among Committees and the influence of article numbers on the level of grants. It provides important insights for public policies in Science and Technology and contributes to the field by evaluating the Health Sciences area using diverse indicators.
Article
Nutrition & Dietetics
Bruno Costa Teixeira, Franccesco Pinto Boeno, Jeam Marcel Geremia, Cleiton da Silva Correa, Andre Luiz Lopes, Rodrigo Cauduro Oliveira Macedo, Randhall Bruce Kreismann Carteri, Eliane Bandinelli, Marco Aurelio Vaz, Jerri Luiz Ribeiro, Alvaro Reischak-Oliveira
Summary: Different types of muscle contraction have different effects on the musculature and inflammatory responses. Acute increases in inflammation markers can increase the risk of thrombus formation and cardiovascular events. This study investigates the effects of concentric and eccentric exercise on hemostasis markers and CRP levels.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Neurosciences
Afonso Kopczynski, Randhall B. Carteri, Marcelo S. Rodolphi, Jean P. Oses, Luiz O. Portela, Cesar A. Geller, Vitoria G. de Oliveira, Marco Antonio De Bastiani, Nathan R. Strogulski, Douglas H. Smith, Luis V. Portela
Summary: Decreasing neurotrophic support and impaired mitochondrial bioenergetics are key mechanisms for long-term neurodegeneration and cognitive decline after traumatic brain injury (TBI). Preconditioning with lower and higher volumes of physical exercise upregulates the CREB-BDNF axis and bioenergetic capability, serving as neural reserves against cognitive impairment after severe TBI. LV and HV exercise increased hippocampal pCREB-CREB-proBDNF-BDNF signaling and mitochondrial coupling efficiency, excess capacity, and leak control, preserving memory fitness after severe TBI.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Gilciane Ceolin, Julia Dubois Moreira, Vitor Breda, Bruna Cunha Mendes, Fabiano Alves Gomes, Rodrigo Barbachan Mansur, Eleonora d'Orsi, Debora Kurrle Rieger, Elisa Brietzke
Summary: This study investigated the long-term association between BMI, waist circumference, and the incidence of depressive symptoms in older adults. The findings showed that obesity was associated with a higher incidence of depressive symptoms compared to overweight individuals after 10 years. Additionally, a larger waist circumference was also related to depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Aline Rigon Zimmer, Bianca Franco Leonardi, Eduardo Rigon Zimmer, Alexandre Pastoris Muller, Grace Gosmann, Luis Valmor Cruz Portela
Summary: This study evaluated the protective effects of Capsicum baccatum red pepper on metabolic syndrome induced by an ultra-processed diet in rats. The results showed that oral administration of C. baccatum along with the ultra-processed diet prevented adipose tissue accumulation, reduced total cholesterol and LDL levels, and improved glucose metabolism, all commonly associated with metabolic syndrome. The study suggests that C. baccatum red pepper is a secure and enriched source of bioactive compounds promising to protect against pathological processes associated with metabolic syndrome.
Article
Biochemistry & Molecular Biology
Blessing A. Obafemi, Isaac A. Adedara, Ana L. A. Segatto, Diogo O. Souza, Joao B. T. da Rocha, Olawande C. Olagoke
Summary: In this study, the mechanism of inflammatory response to organometallic cation methylmercury, common cooking seasoning (NaCl and MSG), and their crosstalk with redox signaling were investigated using the lobster cockroach as a model. The activation of Nox/Duox NADPH oxidases, along with JNK and Rel signaling pathways, was found to play crucial roles during methylmercury and MSG exposure.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Nathan R. Strogulski, Luis V. Portela, Brian M. Polster, David J. Loane
Summary: Traumatic brain injury (TBI) is a devastating neurological disorder characterized by diffuse damage and chronic neurodegeneration. The immune response, particularly the activation of microglia and macrophages, plays a significant role in the ongoing neuroinflammation after TBI. Metabolic adaptations in immune cells, especially in microglia, regulate the immunologic response to noxious stimuli and contribute to the development of pro- or anti-inflammatory states. However, there are still unresolved questions regarding microglial mitochondrial dysfunction, the roles of specific metabolic pathways, and the influence of immunometabolism on chronic neuroinflammation following TBI.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Lisiane Tuon, Natalia Santos Tramontin, Isis Custodio, Vitor Hugo Comim, Barbara Costa, Lariani Tamires Witt Tietbohl, Alexandre Pastoris Muller
Summary: Intellectual disability (ID) is a condition characterized by limitations in cognitive development and adaptive behavior. This study investigated potential biomarkers for ID using clinical assessment, standardized tests, and blood samples. Decreased levels of FKN, NGF- β, and vitamin B12, as well as increased levels of DCFH and nitrite, were found in the ID group. Positive correlations were observed between certain biomarkers and specific domains on the WISC-IV test. TNF- α and oxidative stress biomarkers suggest a complex etiology for ID, requiring further research for better understanding and effective treatments.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Julia D. Moreira, Leticia Vicari Siqueira, Alexandre P. Muller, Lisiane O. Porciuncula, Lucia Vinade, Diogo O. Souza
Summary: Dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) can positively influence the glutamatergic system and prevent seizure-related memory deficits.
NUTRITIONAL NEUROSCIENCE
(2022)