Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel

Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors

(2019) Seung Yeon Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation

(2019) Fayal Abderemane-Ali et al.   NEURON

Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket

(2019) Peilin Yu et al.   Cell Reports

Structural insights into TRPM8 inhibition and desensitization

(2019) Melinda M. Diver et al.   SCIENCE

Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

(2019) Yihe Huang et al.   eLife

Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel

(2019) Ying Yin et al.   Nature Communications

Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling

(2019) Wojciech Kopec et al.   Nature Communications

The ion selectivity filter is not an activation gate in TRPV1-3 channels

(2019) Andrés Jara-Oseguera et al.   eLife

Effects of calcium-binding sites in the S2–S3 loop on human and Nematostella vectensis TRPM2 channel gating processes

(2019) Yu-huan Luo et al.   Journal of Zhejiang University-SCIENCE B

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

(2018) Zhe Zhang et al.   eLife

Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity

(2018) Yuhuan Luo et al.   Frontiers in Pharmacology

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

(2018) Yihe Huang et al.   NATURE

Structures and gating mechanism of human TRPM2

(2018) Longfei Wang et al.   SCIENCE

A critical role of TRPM2 channel in Aβ42 -induced microglial activation and generation of tumor necrosis factor-α

(2017) Sharifah Alawieyah Syed Mortadza et al.   GLIA

Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2

(2017) Peilin Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structures of the calcium-activated, non-selective cation channel TRPM4

(2017) Jiangtao Guo et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Localization of the gate and selectivity filter of the full-length P2X7 receptor

(2017) Anja Pippel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human TRPM4 ion channel in a lipid nanodisc

(2017) Henriette E. Autzen et al.   SCIENCE

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

(2016) Xiao Tao et al.   NATURE

The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to  -Amyloid Oligomer-Related Neurotoxicity and Memory Impairment

(2015) V. G. Ostapchenko et al.   JOURNAL OF NEUROSCIENCE

Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement

(2015) Frank DiMaio et al.   NATURE METHODS

De novo protein structure determination from near-atomic-resolution cryo-EM maps

(2015) Ray Yu-Ruei Wang et al.   NATURE METHODS

TRPM2 Channels Protect against Cardiac Ischemia-Reperfusion Injury

(2014) Barbara A. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia

(2014) M Ye et al.   Cell Death & Disease

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents

(2012) B. Toth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions

(2012) M. Kashio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPM2 modulates insulin secretion in pancreatic β-cells

(2011) Kunitoshi Uchida et al.   Islets

Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death

(2010) C. Blenn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TRPM2 channel properties, functions and therapeutic potentials

(2010) Lin-Hua Jiang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sub-angstrom accuracy in protein loop reconstruction by robotics-inspired conformational sampling

(2009) Daniel J Mandell et al.   NATURE METHODS

Structural determinants of gating in the TRPV1 channel

(2009) Héctor Salazar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

(2009) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Another TRP to Endothelial Dysfunction

(2008) Alexander Dietrich et al.   CIRCULATION RESEARCH

Identification of Pore Residues Engaged in Determining Divalent Cationic Permeation in Transient Receptor Potential Melastatin Subtype Channel 2

(2008) Rong Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY