Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
Authors
Keywords
-
Journal
eLife
Volume 8, Issue -, Pages -
Publisher
eLife Sciences Publications, Ltd
Online
2019-09-12
DOI
10.7554/elife.50175
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
- (2019) Emery Haley et al. Jove-Journal of Visualized Experiments
- Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel
- (2019) Ying Yin et al. SCIENCE
- TRPM4 and TRPM5 Channels Share Crucial Amino Acid Residues for Ca2+ Sensitivity but Not Significance of PI(4,5)P2
- (2019) Soichiro Yamaguchi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2
- (2019) Ondřej Baszczyňski et al. JOURNAL OF ORGANIC CHEMISTRY
- Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates
- (2019) Iordan Iordanov et al. eLife
- Pharmacology of JNJ-28583113: A novel TRPM2 antagonist
- (2019) Lawrence Fourgeaud et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket
- (2019) Peilin Yu et al. Cell Reports
- Functional Charaterization of Zebrafish Transient Receptor Potential Melastatin 2
- (2018) Ha Nam Tran et al. BIOPHYSICAL JOURNAL
- TRPM2 dependence of ROS-induced NLRP3 activation in Alzheimer's disease
- (2018) Malihe Aminzadeh et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation
- (2018) Zhe Zhang et al. eLife
- Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity
- (2018) Yuhuan Luo et al. Frontiers in Pharmacology
- 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury
- (2018) Ersen Eraslan et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Trpm2 Ablation Accelerates Protein Aggregation by Impaired ADPR and Autophagic Clearance in the Brain
- (2018) Yongwoo Jang et al. MOLECULAR NEUROBIOLOGY
- Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium
- (2018) Yihe Huang et al. NATURE
- New tools for the analysis and validation of cryo-EM maps and atomic models
- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
- TRPM2 in the Brain: Role in Health and Disease
- (2018) Giulia Sita et al. Cells
- TRPM2 activation: Paradigm shifted?
- (2018) Ralf Fliegert et al. CELL CALCIUM
- Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease
- (2018) Tae-In Kam et al. SCIENCE
- Structures and gating mechanism of human TRPM2
- (2018) Longfei Wang et al. SCIENCE
- Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2
- (2017) Peilin Yu et al. JOURNAL OF GENERAL PHYSIOLOGY
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- Guidelines for using Bsoft for high resolution reconstruction and validation of biomolecular structures from electron micrographs
- (2017) J. Bernard Heymann PROTEIN SCIENCE
- UCSF ChimeraX: Meeting modern challenges in visualization and analysis
- (2017) Thomas D. Goddard et al. PROTEIN SCIENCE
- MolProbity: More and better reference data for improved all-atom structure validation
- (2017) Christopher J. Williams et al. PROTEIN SCIENCE
- Structure of the cold- and menthol-sensing ion channel TRPM8
- (2017) Ying Yin et al. SCIENCE
- Structure of the human TRPM4 ion channel in a lipid nanodisc
- (2017) Henriette E. Autzen et al. SCIENCE
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- X-ray structures define human P2X3 receptor gating cycle and antagonist action
- (2016) Steven E. Mansoor et al. NATURE
- The TRPM2 ion channel is required for sensitivity to warmth
- (2016) Chun-Hsiang Tan et al. NATURE
- The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia
- (2016) K. Song et al. SCIENCE
- The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity
- (2016) Iordan Iordanov et al. eLife
- ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain
- (2016) Frank J. P. Kühn et al. PLoS One
- Novel Role of Reactive Oxygen Species–ActivatedtrpMelastatin Channel-2 in Mediating Angiogenesis and Postischemic NeovascularizationSignificance
- (2015) Manish Mittal et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Calcium mobilizing second messengers derived from NAD
- (2015) Andreas H. Guse BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- TRPM2, a Susceptibility Gene for Bipolar Disorder, Regulates Glycogen Synthase Kinase-3 Activity in the Brain
- (2015) Y. Jang et al. JOURNAL OF NEUROSCIENCE
- JPred4: a protein secondary structure prediction server
- (2015) Alexey Drozdetskiy et al. NUCLEIC ACIDS RESEARCH
- The role of TRPM2 in pancreatic β-cells and the development of diabetes
- (2014) Kunitoshi Uchida et al. CELL CALCIUM
- Screening and large-scale expression of membrane proteins in mammalian cells for structural studies
- (2014) April Goehring et al. Nature Protocols
- Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating
- (2014) Balázs Tóth et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cooperative Interaction of trp Melastatin Channel Transient Receptor Potential (TRPM2) With Its Splice Variant TRPM2 Short Variant Is Essential for Endothelial Cell Apoptosis
- (2013) Claudie M. Hecquet et al. CIRCULATION RESEARCH
- Structure–Activity Relationship of Adenosine 5′-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) Channel: Rational Design of Antagonists
- (2013) Christelle Moreau et al. JOURNAL OF MEDICINAL CHEMISTRY
- Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling
- (2013) Insa M. A. Ernst et al. Frontiers in Immunology
- Towards automated crystallographic structure refinement withphenix.refine
- (2012) Pavel V. Afonine et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- TRPM2 Ca2+ channel regulates energy balance and glucose metabolism
- (2012) Zhiyou Zhang et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions
- (2012) M. Kashio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
- (2011) F. Sievers et al. Molecular Systems Biology
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice
- (2010) K. Uchida et al. DIABETES
- Identification of Direct and Indirect Effectors of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel
- (2010) Balázs Tóth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TRPM2: a multifunctional ion channel for calcium signalling
- (2010) Adriana Sumoza-Toledo et al. JOURNAL OF PHYSIOLOGY-LONDON
- Four Ca2+Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate
- (2009) László Csanády et al. JOURNAL OF GENERAL PHYSIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started