Structure and transport mechanism of the human cholesterol transporter ABCG1

Structural insights into the lipid and ligand regulation of serotonin receptors

(2021) Peiyu Xu et al.   NATURE

Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies

(2021) Hanzhi Zhang et al.   Communications Biology

Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2

(2021) Julia Kowal et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular basis of cholesterol efflux via ABCG subfamily transporters

(2021) Yingyuan Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

(2021) Qin Yu et al.   Nature Communications

Structure of the Human Cholesterol Transporter ABCG1

(2021) Liga Skarda et al.   JOURNAL OF MOLECULAR BIOLOGY

ABCG2 transports anticancer drugs via a closed-to-open switch

(2020) Benjamin J. Orlando et al.   Nature Communications

Structural and Mechanistic Principles of ABC Transporters

(2020) Christoph Thomas et al.   Annual Review of Biochemistry

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2

(2020) Hongwu Qian et al.   CELL

CHOLESTEROL REVIEW: A METABOLICALLY IMPORTANT MOLECULE

(2020) David S. Schade et al.   Endocrine Practice

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

(2019) Amer Alam et al.   SCIENCE

HDL and Reverse Cholesterol Transport

(2019) Mireille Ouimet et al.   CIRCULATION RESEARCH

Role of cholesterol homeostasis and its efflux pathways in cancer progression

(2019) Bhoomika Sharma et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reverse Cholesterol Transport and Atherosclerosis

(2018) Anand Rohatgi   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

(2018) Ioannis Manolaridis et al.   NATURE

Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells

(2018) Yuri Namba et al.   Frontiers in Oncology

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ABCG1 as a potential oncogene in lung cancer

(2017) Chunyan Tian et al.   Experimental and Therapeutic Medicine

The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion

(2017) Narakorn Khunweeraphong et al.   Scientific Reports

Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550—Brief ReportHighlights

(2016) Elizabeth J. Tarling et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interaction of G protein coupled receptors and cholesterol

(2016) Gerald Gimpl   CHEMISTRY AND PHYSICS OF LIPIDS

Atherosclerosis

(2016) Frank Schaftenaar et al.   CURRENT OPINION IN LIPIDOLOGY

Genetic variants inABCG1are associated with survival of nonsmall-cell lung cancer patients

(2016) Yanru Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Crystal structure of the human sterol transporter ABCG5/ABCG8

(2016) Jyh-Yeuan Lee et al.   NATURE

Functional Cooperativity between ABCG4 and ABCG1 Isoforms

(2016) Zoltán Hegyi et al.   PLoS One

ABC transporter research: going strong 40 years on

(2015) F. L. Theodoulou et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Macrophage-mediated cholesterol handling in atherosclerosis

(2015) Dimitry A. Chistiakov et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity

(2015) Duygu Sag et al.   Nature Communications

Relative roles ofABCG5/ABCG8in liver and intestine

(2014) Jin Wang et al.   JOURNAL OF LIPID RESEARCH

ABCA1, ABCG1, and ABCG4 Are Distributed to Distinct Membrane Meso-Domains and Disturb Detergent-Resistant Domains on the Plasma Membrane

(2014) Osamu Sano et al.   PLoS One

Characterization of the Role of a Highly Conserved Sequence in ATP Binding Cassette Transporter G (ABCG) Family in ABCG1 Stability, Oligomerization, and Trafficking

(2013) Faqi Wang et al.   BIOCHEMISTRY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Cholesterol Efflux and Atheroprotection

(2012) Robert S. Rosenson et al.   CIRCULATION

ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin

(2012) Hiroshi Hirayama et al.   JOURNAL OF LIPID RESEARCH

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis

(2011) Elizabeth J. Tarling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter

(2011) E. J. Tarling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Small Discoidal Pre-β1 HDL Particles Are Efficient Acceptors of Cell Cholesterol via ABCA1 and ABCG1

(2009) Elda Favari et al.   BIOCHEMISTRY

Microscale Fluorescent Thermal Stability Assay for Membrane Proteins

(2008) Alexander I. Alexandrov et al.   STRUCTURE