HDL and Reverse Cholesterol Transport

Cholesteryl Ester Transfer Protein Inhibition for Preventing Cardiovascular Events

(2019) Jane Armitage et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Specific Disruption of Abca1 Targeting Largely Mimics the Effects of miR-33 Knockout on Macrophage Cholesterol Efflux and Atherosclerotic Plaque Development

(2019) Nathan L. Price et al.   CIRCULATION RESEARCH

Smooth muscle cell fate and plasticity in atherosclerosis

(2018) Sima Allahverdian et al.   CARDIOVASCULAR RESEARCH

Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases CCR7 Expression in Plaque Macrophages

(2018) Paul A. Mueller et al.   CIRCULATION

Deciphering the Role of Lipid Droplets in Cardiovascular Disease

(2018) Ira J. Goldberg et al.   CIRCULATION

A Novel Strategy to Prevent Advanced Atherosclerosis and Lower Blood Glucose in a Mouse Model of Metabolic Syndrome

(2018) Jenny E. Kanter et al.   DIABETES

Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease

(2018) Anna Helgadottir et al.   EUROPEAN HEART JOURNAL

Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

(2018) Ashish Misra et al.   Nature Communications

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

(2018) Jaspreet Sandhu et al.   CELL

Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial

(2018) Stephen J. Nicholls et al.   JAMA Cardiology

Cholesterol Mass Efflux Capacity, Incident Cardiovascular Disease, and Progression of Carotid Plaque

(2018) Steven Shea et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A novel approach to measuring macrophage-specific reverse cholesterol transport in vivo in humans

(2017) Marina Cuchel et al.   JOURNAL OF LIPID RESEARCH

Intracoronary Imaging, Reverse Cholesterol Transport, and Transcriptomics

(2017) Adnan K. Chhatriwalla et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

(2017) Ismail Sergin et al.   Nature Communications

Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis

(2017) Nathan L. Price et al.   Cell Reports

Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport

(2017) Souade Ikhlef et al.   PLoS One

miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and EffluxSignificance

(2016) Mireille Ouimet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNA Regulation of Atherosclerosis

(2016) Mark W. Feinberg et al.   CIRCULATION RESEARCH

Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis ModelsNovelty and Significance

(2016) Joel Chappell et al.   CIRCULATION RESEARCH

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

(2016) Yang Xu et al.   HEPATOLOGY

Immune cell screening of a nanoparticle library improves atherosclerosis therapy

(2016) Jun Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical Reversal of Atherosclerosis by FDA-Approved Compound that Transforms Cholesterol into an Anti-Inflammatory “Prodrug”

(2016) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

(2016) Paolo Zanoni et al.   SCIENCE

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

(2016) Sebastian Zimmer et al.   Science Translational Medicine

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

(2016) Danielle L. Michell et al.   Jove-Journal of Visualized Experiments

Artery Tertiary Lymphoid Organs: Powerhouses of Atherosclerosis Immunity

(2016) Changjun Yin et al.   Frontiers in Immunology

Impaired HDL cholesterol efflux in metabolic syndrome is unrelated to glucose tolerance status: the CODAM study

(2016) Wijtske Annema et al.   Scientific Reports

Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like PhenotypeSignificance

(2015) Yuliya Vengrenyuk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Therapeutic Inhibition of miR-33 Promotes Fatty Acid Oxidation but Does Not Ameliorate Metabolic Dysfunction in Diet-Induced ObesitySignificance

(2015) Denuja Karunakaran et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages

(2015) Brenda L. Sanchez-Gaytan et al.   BIOCONJUGATE CHEMISTRY

Association between blood glucose variability and coronary plaque instability in patients with acute coronary syndromes

(2015) Kozo Okada et al.   Cardiovascular Diabetology

Enhanced atheroprotection and lesion remodelling by targeting the foam cell and increasing plasma cholesterol acceptors

(2015) Se-Hee Son et al.   CARDIOVASCULAR RESEARCH

RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes

(2015) Gurdip Daffu et al.   DIABETES

Cholesterol trafficking and distribution

(2015) David B. Iaea et al.   Essays in Biochemistry

MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

(2015) Mireille Ouimet et al.   JOURNAL OF CLINICAL INVESTIGATION

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2

(2015) Maryem A. Hussein et al.   PLoS One

Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study

(2015) Danish Saleheen et al.   Lancet Diabetes & Endocrinology

Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice

(2015) Florian Willecke et al.   PLoS One

Lymphatic Vessel Insufficiency in Hypercholesterolemic Mice Alters Lipoprotein Levels and Promotes Atherogenesis

(2014) Taina Vuorio et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ABCA1 and nascent HDL biogenesis

(2014) Shuhui Wang et al.   BIOFACTORS

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

(2014) Sima Allahverdian et al.   CIRCULATION

Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis

(2014) Susanne Feil et al.   CIRCULATION RESEARCH

High-Density Lipoprotein and Atherosclerosis Regression

(2014) Jonathan E. Feig et al.   CIRCULATION RESEARCH

miR33 Inhibition Overcomes Deleterious Effects of Diabetes Mellitus on Atherosclerosis Plaque Regression in Mice

(2014) Emilie Distel et al.   CIRCULATION RESEARCH

Quantification of HDL Particle Concentration by Calibrated Ion Mobility Analysis

(2014) P. M. Hutchins et al.   CLINICAL CHEMISTRY

Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice

(2014) L. Goedeke et al.   EMBO Molecular Medicine

Association of HDL-C and apolipoprotein A-I with the risk of type 2 diabetes in subjects with impaired fasting glucose

(2014) You-Cheol Hwang et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Liver X receptors in lipid metabolism: opportunities for drug discovery

(2014) Cynthia Hong et al.   NATURE REVIEWS DRUG DISCOVERY

HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events

(2014) Anand Rohatgi et al.   NEW ENGLAND JOURNAL OF MEDICINE

A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation

(2014) Raphaël Duivenvoorden et al.   Nature Communications

Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117 411 patients

(2014) D. Keene et al.   BMJ-British Medical Journal

Therapeutic Silencing of MicroRNA-33 Inhibits the Progression of Atherosclerosis in Ldlr −/− Mice—Brief Report

(2013) Noemi Rotllan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Paradoxical Association of Enhanced Cholesterol Efflux With Increased Incident Cardiovascular Risks

(2013) Xin-Min Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

(2013) Prabhakara R. Nagareddy et al.   Cell Metabolism

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice

(2013) Marit Westerterp et al.   CIRCULATION RESEARCH

Update on Cardiovascular Outcomes at 30 Years of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

(2013) John M. Lachin et al.   DIABETES CARE

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice

(2013) Catherine Martel et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond

(2013) Amy S. Shah et al.   JOURNAL OF LIPID RESEARCH

Cardioprotective functions of HDLs

(2013) Kerry-Anne Rye et al.   JOURNAL OF LIPID RESEARCH

A big role for small RNAs in HDL homeostasis

(2013) Mireille Ouimet et al.   JOURNAL OF LIPID RESEARCH

Hypoxia in murine atherosclerotic plaques and its adverse effects on macrophages

(2013) Saj Parathath et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Early steps in reverse cholesterol transport

(2013) Shobha Ghosh   Current Opinion in Endocrinology Diabetes and Obesity

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice

(2013) Takahiro Horie et al.   Nature Communications

MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice

(2013) Takahiro Horie et al.   Journal of the American Heart Association

Lipoprotein remodeling generates lipid-poor apolipoprotein A-I particles in human interstitial fluid

(2012) Norman E. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Red Blood Cells Play a Role in Reverse Cholesterol Transport

(2012) Kimberly T. Hung et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High-Density Lipoprotein Function, Dysfunction, and Reverse Cholesterol Transport

(2012) Edward A. Fisher et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Feedback Regulation of Cholesterol Uptake by the LXR–IDOL–LDLR Axis

(2012) Li Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

HDL and Cardiovascular Risk

(2012) Bernd Hewing et al.   CIRCULATION RESEARCH

Advanced glycated albumin isolated from poorly controlled type 1 diabetes mellitus patients alters macrophage gene expression impairing ABCA-1-mediated reverse cholesterol transport

(2012) Adriana Machado-Lima et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models

(2012) H. Low et al.   DIABETOLOGIA

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Is it time to revise the HDL cholesterol hypothesis?

(2012) Daniel J Rader et al.   NATURE MEDICINE

Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies

(2012) Wijtske Annema et al.   Nutrition & Metabolism

Liver X receptor biology and pharmacology: new pathways, challenges and opportunities

(2012) Tomas Jakobsson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Reverse Cholesterol Transport Revisited

(2011) Gemma Brufau et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel In Vivo Method for Measuring Cholesterol Mass Flux in Peripheral Macrophages

(2011) Ginny L. Weibel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of Lipid Droplet Cholesterol Efflux From Macrophage Foam Cells

(2011) Mireille Ouimet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism

(2011) Sajesh Parathath et al.   CIRCULATION RESEARCH

Role of Hepatic Lipase and Endothelial Lipase in High-Density Lipoprotein—Mediated Reverse Cholesterol Transport

(2011) Wijtske Annema et al.   Current Atherosclerosis Reports

Diabetes Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice

(2011) S. Parathath et al.   DIABETES

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

(2011) Katey J. Rayner et al.   JOURNAL OF CLINICAL INVESTIGATION

Krüppel-like factor 4 regulates macrophage polarization

(2011) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe–/– mice during disease regression

(2011) Stephane Potteaux et al.   JOURNAL OF CLINICAL INVESTIGATION

A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol

(2011) Sandhya Sankaranarayanan et al.   JOURNAL OF LIPID RESEARCH

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

(2011) Katey J. Rayner et al.   NATURE

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

HDL and Cardiovascular-Disease Risk — Time for a New Approach?

(2011) Jay Heinecke   NEW ENGLAND JOURNAL OF MEDICINE

Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis

(2011) Amit V. Khera et al.   NEW ENGLAND JOURNAL OF MEDICINE

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Type 2 Diabetes Is Associated with Reduced ATP-Binding Cassette Transporter A1 Gene Expression, Protein and Function

(2011) Dipesh C. Patel et al.   PLoS One

Statins Promote the Regression of Atherosclerosis via Activation of the CCR7-Dependent Emigration Pathway in Macrophages

(2011) Jonathan E. Feig et al.   PLoS One

ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter

(2011) E. J. Tarling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonenzymatic Glycation Impairs the Antiinflammatory Properties of Apolipoprotein A-I

(2010) Estelle Nobécourt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages

(2010) Margarita de la Llera-Moya et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Critical Role of Neutral Cholesterol Ester Hydrolase 1 in Cholesterol Removal From Human Macrophages

(2010) Masaki Igarashi et al.   CIRCULATION RESEARCH

Future Therapeutic Directions in Reverse Cholesterol Transport

(2010) Amit V. Khera et al.   Current Atherosclerosis Reports

High-density lipoprotein heterogeneity and function in reverse cholesterol transport

(2010) George H Rothblat et al.   CURRENT OPINION IN LIPIDOLOGY

Where do they come from? Insights into autophagosome formation

(2010) Maho Hamasaki et al.   FEBS LETTERS

miR-33 links SREBP-2 induction to repression of sterol transporters

(2010) T. J. Marquart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

(2010) L. Yvan-Charvet et al.   SCIENCE

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

(2010) S. H. Najafi-Shoushtari et al.   SCIENCE

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

(2010) K. J. Rayner et al.   SCIENCE

Divergent Effects of α-Tocopherol and Vitamin C on the Generation of Dysfunctional HDL Associated with Diabetes and the Hp 2-2 Genotype

(2009) Rabea Asleh et al.   ANTIOXIDANTS & REDOX SIGNALING

Intracellular sterol dynamics

(2009) Bruno Mesmin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes

(2009) Chongren Tang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ablation of Neutral Cholesterol Ester Hydrolase 1 Accelerates Atherosclerosis

(2009) Motohiro Sekiya et al.   Cell Metabolism

ATP-Binding Cassette Transporter A1 Expression and Apolipoprotein A-I Binding Are Impaired in Intima-Type Arterial Smooth Muscle Cells

(2009) Hong Y. Choi et al.   CIRCULATION

Lipid Incorporation Inhibits Src-Dependent Assembly of Fibronectin and Type I Collagen by Vascular Smooth Muscle Cells

(2009) Matthew J. Frontini et al.   CIRCULATION RESEARCH

Impaired serum capacity to induce cholesterol efflux is associated with endothelial dysfunction in type 2 diabetes mellitus

(2009) Huali Zhou et al.   Diabetes & Vascular Disease Research

Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation

(2009) Yuya Azuma et al.   GENES TO CELLS

Macrophage cholesteryl ester mobilization and atherosclerosis

(2009) Shobha Ghosh et al.   VASCULAR PHARMACOLOGY

Reduced Expression of ATP-Binding Cassette Transporter G1 Increases Cholesterol Accumulation in Macrophages of Patients With Type 2 Diabetes Mellitus

(2008) Jeremy P. Mauldin et al.   CIRCULATION

Infusion of Reconstituted High-Density Lipoprotein Leads to Acute Changes in Human Atherosclerotic Plaque

(2008) James A. Shaw et al.   CIRCULATION RESEARCH

Phospholipids mediated conversion of HDLs generates specific apoA-II pre-β mobility particles

(2008) Małgorzata Wróblewska et al.   JOURNAL OF LIPID RESEARCH

The HDL proteome: a marker–and perhaps mediator–of coronary artery disease: Fig. 1.

(2008) Jay W. Heinecke   JOURNAL OF LIPID RESEARCH