BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease

Molecular mechanisms and physiological functions of mitophagy

(2021) Mashun Onishi et al.   EMBO JOURNAL

Autophagy and organelle homeostasis in cancer

(2021) Dannah R. Miller et al.   DEVELOPMENTAL CELL

Nix-mediated Mitophagy Modulates Mitochondrial Damage during Intestinal Inflammation

(2020) Garret Vincent et al.   ANTIOXIDANTS & REDOX SIGNALING

Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery

(2020) Mija Marinković et al.   Autophagy

NIX compensates lost role of parkin in cd-induced mitophagy in HeLa cells through phosphorylation

(2020) Sajid Naeem et al.   TOXICOLOGY LETTERS

BNIP3 decreases the LPS-induced inflammation and apoptosis of chondrocytes by promoting the development of autophagy

(2020) Zetao Ma et al.   Journal of Orthopaedic Surgery and Research

BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation

(2020) Simone C. da Silva Rosa et al.   Autophagy

Mitophagy in degenerative joint diseases

(2020) Kai Sun et al.   Autophagy

Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy

(2020) Hongxu Xian et al.   CELL DEATH AND DIFFERENTIATION

Nix/BNIP3L-dependent mitophagy accounts for airway epithelial cell injury induced by cigarette smoke

(2019) Ming Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation

(2019) Mark A. Lampert et al.   Autophagy

Emerging views of mitophagy in immunity and autoimmune diseases

(2019) Ye Xu et al.   Autophagy

Potential Roles of NIX/BNIP3L Pathway in Rat Traumatic Brain Injury

(2019) Jialing Ma et al.   CELL TRANSPLANTATION

EWSR1-FLI1 activation of the cancer/testis antigen FATE1 promotes Ewing sarcoma survival

(2019) Zachary R. Gallegos et al.   MOLECULAR AND CELLULAR BIOLOGY

Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer

(2019) Timothy J Humpton et al.   Cancer Discovery

Mitochondria in Health and Disease

(2019) Sarah J. Annesley et al.   Cells

Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma

(2019) Jinkyu Jung et al.   CANCER RESEARCH

Mitochondrial morphology regulates organellar Ca2+ uptake and changes cellular Ca2+ homeostasis

(2019) Alicia J. Kowaltowski et al.   FASEB JOURNAL

NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells

(2019) Shubhranshu S. Gupta et al.   Cell Reports

Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis

(2018) Zhi-li Ren et al.   ACTA PHARMACOLOGICA SINICA

BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming

(2018) Lorena Esteban-Martínez et al.   Autophagy

AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells

(2018) Nina Meyer et al.   Autophagy

Thiamine preserves mitochondrial function in a rat model of traumatic brain injury, preventing inactivation of the 2-oxoglutarate dehydrogenase complex

(2018) Garik V. Mkrtchyan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death

(2018) Saverio Marchi et al.   CELL CALCIUM

Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition

(2018) Wajihah Mughal et al.   CELL DEATH AND DIFFERENTIATION

BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation

(2018) Lisa A. Brennan et al.   EXPERIMENTAL EYE RESEARCH

Autophagy and mitophagy in ALS

(2018) Chantell S. Evans et al.   NEUROBIOLOGY OF DISEASE

Multiple pathways for mitophagy: A neurodegenerative conundrum for Parkinson’s disease

(2018) Charleen T. Chu   NEUROSCIENCE LETTERS

The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord

(2018) Nathan Duval et al.   Frontiers in Cellular Neuroscience

Upregulation of BCL2 19 kD Protein-Interacting Protein 3 (BNIP3) is Predictive of Unfavorable Prognosis in Uveal Melanoma

(2018) Zhongming Jiang et al.   MEDICAL SCIENCE MONITOR

Mitochondrial Dysfunction and Mitophagy Defect Triggered by Heterozygous GBA Mutations

(2018) Hongyu Li et al.   Autophagy

DNA methylation of the promoter region of bnip3 and bnip3l genes induced by metabolic programming

(2018) Vincent Veron et al.   BMC GENOMICS

Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

(2018) Gloria M Palomo et al.   EMBO Molecular Medicine

The Impact of Mitochondrial and Nuclear DNA Variants on Late-Onset Alzheimer's Disease Risk

(2018) Aleksandra Maruszak et al.   JOURNAL OF ALZHEIMERS DISEASE

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

(2018) Anthea Di Rita et al.   Nature Communications

Knockdown of BNIP3L or SQSTM1 alters cellular response to mitochondria target drugs

(2018) Rowena Rodrigo et al.   Autophagy

Comprehensive molecular biomarker identification in breast cancer brain metastases

(2017) Hans-Juergen Schulten et al.   Journal of Translational Medicine

Expanding perspectives on the significance of mitophagy in cancer

(2017) Lauren E. Drake et al.   SEMINARS IN CANCER BIOLOGY

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

Dominant Optic Atrophy and Leber’s Hereditary Optic Neuropathy: Update on Clinical Features and Current Therapeutic Approaches

(2017) Bo Young Chun et al.   Seminars in Pediatric Neurology

Impaired Mitophagy Plays a Role in Denervation of Neuromuscular Junctions in ALS Mice

(2017) Robert S. Rogers et al.   Frontiers in Neuroscience

Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease

(2017) Brianada Koentjoro et al.   Scientific Reports

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins

(2017) Vladimir V. Rogov et al.   Scientific Reports

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

p75 neurotrophin receptor and its novel interaction partner, NIX, are involved in neuronal apoptosis after intracerebral hemorrhage

(2016) Jiabing Shen et al.   CELL AND TISSUE RESEARCH

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity

(2016) Marc J. Tol et al.   DIABETES

BNIP3L in myelodysplastic syndromes and acute myeloid leukemia: impact on disease outcome and cellular response to decitabine

(2016) Mariana Lazarini et al.   HAEMATOLOGICA

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

(2016) Victoria E Pedanou et al.   eLife

BNIP3L in myelodysplastic syndromes and acute myeloid leukemia: impact on disease outcome and cellular response to decitabine

(2016) Mariana Lazarini et al.   HAEMATOLOGICA

Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy

(2015) Jie Li et al.   Autophagy

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

(2015) Nidhi Sahni et al.   CELL

Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease

(2015) S. Hwang et al.   EMBO Molecular Medicine

The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway

(2015) Feng Gao et al.   HUMAN MOLECULAR GENETICS

BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory

(2015) Timothy E. O’Sullivan et al.   IMMUNITY

Mitochondrial dysfunction and seizures: the neuronal energy crisis

(2015) Gábor Zsurka et al.   LANCET NEUROLOGY

Cerebrospinal Fluid from Sporadic Amyotrophic Lateral Sclerosis Patients Induces Mitochondrial and Lysosomal Dysfunction

(2015) Aparna Sharma et al.   NEUROCHEMICAL RESEARCH

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis

(2015) L Roca-Alonso et al.   Cell Death & Disease

Regulation of mitophagy in ischemic brain injury

(2015) Yang Yuan et al.   Neuroscience Bulletin

MicroRNA-302/367 Cluster Governs hESC Self-Renewal by Dually Regulating Cell Cycle and Apoptosis Pathways

(2015) Zhonghui Zhang et al.   Stem Cell Reports

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

(2014) Nathalie M. Mazure et al.   Autophagy

Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase

(2014) A Hamacher-Brady et al.   CELL DEATH AND DIFFERENTIATION

BNIP3 Interacting with LC3 Triggers Excessive Mitophagy in Delayed Neuronal Death in Stroke

(2014) Ruo-Yang Shi et al.   CNS Neuroscience & Therapeutics

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolism and function of mitochondrial cardiolipin

(2014) Mindong Ren et al.   PROGRESS IN LIPID RESEARCH

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells

(2013) Xiaojun Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miRNA expression is modulated over time after focal ischaemia: up-regulation of miR-347 promotes neuronal apoptosis

(2013) Carme Gubern et al.   FEBS Journal

Up-regulated expression of Bnip3L after intracerebral hemorrhage in adult rats

(2013) Ying Rui et al.   JOURNAL OF MOLECULAR HISTOLOGY

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

(2013) Wei-jia Wang et al.   Nature Chemical Biology

Changes in Levels of Hypoxia-Induced Mediators in Rat Hippocampus During Chronic Cerebral Hypoperfusion

(2013) Ying Yang et al.   NEUROCHEMICAL RESEARCH

Induction of Neuronal Mitophagy in Acute Spinal Cord Injury in Rats

(2013) Datang Yu et al.   NEUROTOXICITY RESEARCH

A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes

(2012) Ji Zhang et al.   Autophagy

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Differential expression of BNIP family members of BH3-only proteins during the development and after axotomy in the rat

(2012) Bongki Cho et al.   MOLECULES AND CELLS

The acquisition of resistance to TNFα in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray

(2011) Etienne Moussay et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Adaptation to oxygen deprivation in cultures of human pluripotent stem cells, endothelial progenitor cells, and umbilical vein endothelial cells

(2010) Hasan Erbil Abaci et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanisms and Biology of B-Cell Leukemia/Lymphoma 2/Adenovirus E1B Interacting Protein 3 and Nip-Like Protein X

(2010) Ji Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes

(2010) Kei Fujimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth factor signaling permits hypoxia-induced autophagy by a HIF1α-dependent, BNIP3/3L-independent transcriptional program in human cancer cells

(2009) Simon Wilkinson et al.   Autophagy

Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy

(2009) Melanie Schwarten et al.   Autophagy

Extraordinary pleiotropy of protein kinase CK2 revealed by weblogo phosphoproteome analysis

(2009) Mauro Salvi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

The Cell Cycle Factor E2F-1 Activates Bnip3 and the Intrinsic Death Pathway in Ventricular Myocytes

(2007) Natalia Yurkova et al.   CIRCULATION RESEARCH