Role of Sumac (Rhus coriaria L.) in the management of metabolic syndrome and related disorders: Focus on NAFLD-atherosclerosis interplay

Pharmacological and Antioxidant Activities of Rhus coriaria L. (Sumac)

(2021) Halima Alsamri et al.   Antioxidants

Dietary Polyphenols and Non-Alcoholic Fatty Liver Disease

(2021) Ludovico Abenavoli et al.   Nutrients

Mango (Mangifera indica L.) Polyphenols: Anti-Inflammatory Intestinal Microbial Health Benefits, and Associated Mechanisms of Actions

(2021) Hyemee Kim et al.   MOLECULES

Origanum syriacum L. (Za’atar), from Raw to Go: A Review

(2021) Reem Abu Alwafa et al.   Plants-Basel

Sumac fruit supplementation improve glycemic parameters in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis

(2021) Atie Ghafouri et al.   PHYTOMEDICINE

Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota

(2021) Wen-Long Sun et al.   Cell Reports

Gallic acid protects against the COPD-linked lung inflammation and emphysema in mice

(2020) Esha Singla et al.   INFLAMMATION RESEARCH

Cyanidin‐3‐O‐glucoside improves non‐alcoholic fatty liver disease by promoting PINK1‐mediated mitophagy in mice

(2020) Xinwei Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes

(2020) Miori Tanaka et al.   Nutrients

The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism

(2020) Sha Li et al.   Frontiers in Pharmacology

Metabolomics reveals impact of seven functional foods on metabolic pathways in a gut microbiota model

(2020) Mohamed A. Farag et al.   Journal of Advanced Research

Growth, Carcass Composition, Haematology and Immunity of Broilers Supplemented with Sumac Berries (Rhus coriaria L.) and Thyme (Thymus vulgaris)

(2020) Amir Ahmadian et al.   Animals

Rhus coriaria L. Fruit Extract Prevents UV-A-Induced Genotoxicity and Oxidative Injury in Human Microvascular Endothelial Cells

(2020) Emma Nozza et al.   Antioxidants

Oral gallic acid improve liver steatosis and metabolism modulating hepatic lipogenic markers in obese mice

(2020) Jaciara Neves Sousa et al.   EXPERIMENTAL GERONTOLOGY

Evaluation of male infertility treatment following Rhus coriaria extract administration on rats exposed to morphine

(2020) Shiva Roshankhah et al.   MOLECULAR BIOLOGY REPORTS

The beneficial effects of sumac ( Rhus coriaria L.) supplementation along with restricted calorie diet on anthropometric indices, oxidative stress, and inflammation in overweight or obese women with depression: A randomized clinical trial

(2020) Nastaran Hariri et al.   PHYTOTHERAPY RESEARCH

Gallic acid improves recognition memory and decreases oxidative‐inflammatory damage in the rat hippocampus with metabolic syndrome

(2020) Alfonso Diaz et al.   SYNAPSE

Methyl gallate attenuates inflammation induced by Toll-like receptor ligands by inhibiting MAPK and NF-Κb signaling pathways

(2020) Luana Barbosa Correa et al.   INFLAMMATION RESEARCH

Activity‐guided isolation of α‐amylase, α‐glucosidase, and pancreatic lipase inhibitory compounds from Rhus coriaria L

(2020) Hasya Nazlı Gök et al.   JOURNAL OF FOOD SCIENCE

Impact of Cyanidin-3-Glucoside on Gut Microbiota and Relationship with Metabolism and Inflammation in High Fat-High Sucrose Diet-Induced Insulin Resistant Mice

(2020) Fei Huang et al.   Microorganisms

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma

(2020) Peter Kubatka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases

(2020) Rosalba Leuci et al.   Foods

Repressive effect of Rhus coriaria L. fruit extracts on microglial cells-mediated inflammatory and oxidative stress responses

(2020) Mohamad Khalil et al.   JOURNAL OF ETHNOPHARMACOLOGY

Measurement of anticancer, antidiabetic and anticholinergic properties of sumac (Rhus coriaria): analysis of its phenolic compounds by LC–MS/MS

(2019) Hatice Tohma et al.   Journal of Food Measurement and Characterization

Nonalcoholic fatty liver disease represents a greater metabolic burden in patients with atherosclerosis

(2019) Jie Han et al.   MEDICINE

In vitro evidences of the traditional use of Rhus coriaria L. fruits against skin inflammatory conditions

(2019) Saba Khalilpour et al.   JOURNAL OF ETHNOPHARMACOLOGY

Evaluation of in vitro and in vivo genotoxic and antigenotoxic effects of Rhus coriaria

(2019) Taygun Timocin et al.   DRUG AND CHEMICAL TOXICOLOGY

Antidiabetic potential of gallic acid from Emblica officinalis: Improved glucose transporters and insulin sensitivity through PPAR-γ and Akt signaling

(2019) Bhavesh C. Variya et al.   PHYTOMEDICINE

Reduction of expression of IL‐18, IL‐1β genes in the articular joint by sumac fruit extract ( Rhus coriaria L.)

(2019) Amin Momeni et al.   Molecular Genetics & Genomic Medicine

Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of Rhus coriaria on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues

(2019) Sami A. Gabr et al.   Evidence-based Complementary and Alternative Medicine

Importance of ethnopharmacological studies in drug discovery: role of medicinal plants

(2019) Ipek Süntar   PHYTOCHEMISTRY REVIEWS

Sumac ( Rhus coriaria ) for the prevention and treatment of necrotizing enterocolitis

(2019) Sehribanu Isik et al.   JOURNAL OF FOOD BIOCHEMISTRY

Oral gallic acid improves metabolic profile by modulating SIRT1 expression in obese mice brown adipose tissue: A molecular and bioinformatic approach

(2019) Alanna Fernandes Paraíso et al.   LIFE SCIENCES

Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis

(2019) Yu-Ling Liu et al.   MOLECULAR NEUROBIOLOGY

Gallic acid regulates adipocyte hypertrophy and suppresses inflammatory gene expression induced by the paracrine interaction between adipocytes and macrophages in vitro and in vivo

(2019) Miori Tanaka et al.   NUTRITION RESEARCH

NAFLD and Atherosclerosis: Two Sides of the Same Dysmetabolic Coin?

(2019) Daniela Stols-Gonçalves et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effect of Daily Ingestion of Quercetin-Rich Onion Powder for 12 Weeks on Visceral Fat: A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study

(2019) Mie Nishimura et al.   Nutrients

Effect of sumac (Rhus Coriaria) on blood lipids: A systematic review and meta-analysis

(2018) Maryam Akbari-Fakhrabadi et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Potential Cardioprotective Effects of Sumac Capsule in Patients With Hyperlipidemia: A Triple-Blind Randomized, Placebo-Controlled Crossover Trial

(2018) Sedigheh Asgary et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Gallic Acid Improves Health-Associated Biochemical Parameters and Prevents Oxidative Damage of DNA in Type 2 Diabetes Patients: Results of a Placebo-Controlled Pilot Study

(2018) Franziska Ferk et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of superfoods on risk factors of metabolic syndrome: a systematic review of human intervention trials

(2018) José J. van den Driessche et al.   Food & Function

Rhus coriaria L. (Sumac) Evokes Endothelium-Dependent Vasorelaxation of Rat Aorta: Involvement of the cAMP and cGMP Pathways

(2018) Mohammad A. Anwar et al.   Frontiers in Pharmacology

Volatile profiling in Rhus coriaria fruit (sumac) from three different geographical origins and upon roasting as analyzed via solid-phase microextraction

(2018) Mohamed A. Farag et al.   PeerJ

Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice

(2018) Elena Daveri et al.   Redox Biology

Relationship Between Metabolic Disorders and Breast Cancer Incidence and Outcomes. Is There a Preventive and Therapeutic Role for Berberine?

(2018) MASSIMILIANO CAZZANIGA et al.   ANTICANCER RESEARCH

Molecular pathways of nonalcoholic fatty liver disease development and progression

(2018) Fernando Bessone et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effects of Rhus coriaria L. hydroalcoholic extract on the lipid and antioxidant profile in high fat diet-induced hepatic steatosis in rats

(2018) Abdolmomen Ghaeni Pasavei et al.   DRUG AND CHEMICAL TOXICOLOGY

Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice

(2017) Tao Hu et al.   EUROPEAN JOURNAL OF NUTRITION

Influence of sumac (Rhus Coriaria L.) and ginger (Zingiber officinale ) on egg yolk fatty acid, cholesterol and blood parameters in laying hens

(2017) Y. Gurbuz et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Angiogenesis in metabolic-vascular disease

(2017) Georg Breier et al.   THROMBOSIS AND HAEMOSTASIS

NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet

(2017) Antonella Amato et al.   Nutrients

Protective effect of Rhus coriaria fruit extracts against hydrogen peroxide-induced oxidative stress in muscle progenitors and zebrafish embryos

(2017) Fadia Najjar et al.   PeerJ

Rhus coriaria increases protein ubiquitination, proteasomal degradation and triggers non-canonical Beclin-1-independent autophagy and apoptotic cell death in colon cancer cells

(2017) Khawlah Athamneh et al.   Scientific Reports

Association between Metabolic Syndrome and Cancer

(2016) Mehmet Uzunlulu et al.   ANNALS OF NUTRITION AND METABOLISM

Improvement in non-alcoholic fatty liver disease severity is associated with a reduction in carotid intima-media thickness progression

(2016) Lokpal Bhatia et al.   ATHEROSCLEROSIS

Wnt/β-catenin signaling plays a distinct role in methyl gallate–mediated inhibition of adipogenesis

(2016) Miso Jeon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methyl gallate limits infection in mice challenged withBrucella abortuswhile enhancing the inflammatory response

(2016) A.W.B. Reyes et al.   JOURNAL OF APPLIED MICROBIOLOGY

Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice

(2016) Hong-ming Su et al.   Journal of Zhejiang University-SCIENCE B

Immunotherapy with methyl gallate, an inhibitor of Treg cell migration, enhances the anti-cancer effect of cisplatin therapy

(2016) Hyunseong Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Healing effects of sumac (Rhus coriaria) in streptozotocin-induced diabetic rats

(2016) Abdulahad Doğan et al.   PHARMACEUTICAL BIOLOGY

Regressive Effect of Myricetin on Hepatic Steatosis in Mice Fed a High-Fat Diet

(2016) Shu-Fang Xia et al.   Nutrients

Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways

(2016) Hussain El Hasasna et al.   Scientific Reports

Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial

(2015) Verena Brüll et al.   BRITISH JOURNAL OF NUTRITION

Gallic Acid Regulates Body Weight and Glucose Homeostasis Through AMPK Activation

(2015) Khanh V. Doan et al.   ENDOCRINOLOGY

Liraglutide improves carotid intima-media thickness in patients with type 2 diabetes and non-alcoholic fatty liver disease: an 8-month prospective pilot study

(2015) Ali A Rizvi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

HPLC–DAD–ESI-MS/MS screening of bioactive components from Rhus coriaria L. (Sumac) fruits

(2015) Ibrahim M. Abu-Reidah et al.   FOOD CHEMISTRY

Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats

(2015) Mehmet SAĞLAM et al.   Journal of Applied Oral Science

Effects of a triplex mixture ofPeganum harmala, Rhus coriaria, andUrtica dioicaaqueous extracts on metabolic and histological parameters in diabetic rats

(2015) Fereydoon Abedi Gaballu et al.   PHARMACEUTICAL BIOLOGY

High-Risk Coronary Plaque at Coronary CT Angiography Is Associated with Nonalcoholic Fatty Liver Disease, Independent of Coronary Plaque and Stenosis Burden: Results from the ROMICAT II Trial

(2015) Stefan B. Puchner et al.   RADIOLOGY

Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation

(2015) Hussain El Hasasna et al.   Scientific Reports

Effects of Hydro-Alcoholic Extract ofRhus coriaria(Sumac) Seeds on Reproductive Complications of Nicotinamide-Streptozotocin Induced Type-2 Diabetes in Male Mice

(2015) Akram Ahangarpour et al.   World Journal of Mens Health

Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease

(2014) Christopher J. A. Pugh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Gallic acid attenuates high-fat diet fed-streptozotocin-induced insulin resistance via partial agonism of PPARγ in experimental type 2 diabetic rats and enhances glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway

(2014) Gopalsamy Rajiv Gandhi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

(2014) Krishnan Bhaskaran et al.   LANCET

LDL-Migration Index (LDL-MI), an Indicator of Small Dense Low-Density Lipoprotein (sdLDL), Is Higher in Non-Alcoholic Steatohepatitis than in Non-Alcoholic Fatty Liver: A Multicenter Cross-Sectional Study

(2014) Kento Imajo et al.   PLoS One

Is Cancer a Metabolic Disease?

(2013) Hilary A. Coller   AMERICAN JOURNAL OF PATHOLOGY

Antitumor activity of methyl gallate by inhibition of focal adhesion formation and Akt phosphorylation in glioma cells

(2013) Sang-Hyun Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Treatment of Diabetes in the Mouse Model by Delphinidin and Cyanidin Hydrochloride in Free and Liposomal Forms

(2013) Amir Gharib et al.   PLANTA MEDICA

Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice

(2013) Eun-Jung Bak et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Relation between augmentation index and adiponectin during one-year metformin treatment for nonalcoholic steatohepatosis: effects beyond glucose lowering?

(2012) Marina Shargorodsky et al.   Cardiovascular Diabetology

Cancer prevention in Europe

(2012) Attilio Giacosa et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

A rapid profiling of gallotannins and flavonoids of the aqueous extract of Rhus coriaria L. by flow injection analysis with high-resolution mass spectrometry assisted with database searching

(2012) Luca Regazzoni et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Role of reactive oxygen and nitrogen species in the vascular responses to inflammation

(2011) Peter R. Kvietys et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of dietary inclusion of Rhus coriaria on internal milieu of rabbits

(2011) M. Capcarova et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity

(2011) Xiaoyi Wei et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions

(2011) Philippe Rasoanaivo et al.   MALARIA JOURNAL

Treatment with insulin sensitizer metformin improves arterial properties, metabolic parameters, and liver function in patients with nonalcoholic fatty liver disease: a randomized, placebo-controlled trial

(2011) Elena Sofer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Methyl Gallate Exhibits Potent Antitumor Activities by Inhibiting Tumor Infiltration of CD4+CD25+ Regulatory T Cells

(2010) H. Lee et al.   JOURNAL OF IMMUNOLOGY

Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study

(2009) Sarah Egert et al.   BRITISH JOURNAL OF NUTRITION

The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation

(2009) R. K. Simmons et al.   DIABETOLOGIA

A search for hepatoprotective activity of aqueous extract of Rhus coriaria L. against oxidative stress cytotoxicity

(2009) Jalal Pourahmad et al.   FOOD AND CHEMICAL TOXICOLOGY

Serum Lipid and Blood Pressure Responses to Quercetin Vary in Overweight Patients by Apolipoprotein E Genotype

(2009) Sarah Egert et al.   JOURNAL OF NUTRITION

Persistent Impairment of Endothelial Vasomotor Function Has a Negative Impact on Outcome in Patients With Coronary Artery Disease

(2009) Yoshinobu Kitta et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Microelement contents and fatty acid compositions ofRhus coriariaL. andPistacia terebinthusL. fruits spread commonly in the south eastern Anatolia region of Turkey

(2009) Süleyman Kizil et al.   NATURAL PRODUCT RESEARCH

Anti-Ischemic Activity and Endothelium-Dependent Vasorelaxant Effect of Hydrolysable Tannins from the Leaves ofRhus coriaria(Sumac) in Isolated Rabbit Heart and Thoracic Aorta

(2009) Giangiacomo Beretta et al.   PLANTA MEDICA

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET

Functional food ingredient quality: Opportunities to improve public health by compendial standardization

(2008) J.C. Griffiths et al.   Journal of Functional Foods