An Update on Innate Immune Responses during SARS-CoV-2 Infection

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

(2021) Mohamed M. Aboudounya et al.   MEDIATORS OF INFLAMMATION

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation

(2021) Wenjing Wang et al.   Cellular & Molecular Immunology

SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO

(2021) Jing Wu et al.   Cell Reports

SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response

(2021) Soo Jin Oh et al.   Cells

SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome Activation

(2021) Na-Eun Kim et al.   Microorganisms

Innate immune sensing of coronavirus and viral evasion strategies

(2021) Yusuke Kasuga et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

SARS-CoV-2 non-structural protein 1 inhibits the interferon response by causing depletion of key host signaling factors.

(2021) Anil Kumar et al.   JOURNAL OF VIROLOGY

Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions

(2021) Xiaopan Gao et al.   Nature Communications

SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1

(2021) Liyan Sui et al.   Frontiers in Immunology

ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

(2021) GuanQun Liu et al.   Nature Microbiology

SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist

(2021) Aixin Li et al.   JOURNAL OF VIROLOGY

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

(2021) Pan Pan et al.   Nature Communications

Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

(2021) Chia-Ming Su et al.   Scientific Reports

SARS-CoV-2: from its discovery to genome structure, transcription, and replication

(2021) Ayslan Castro Brant et al.   Cell and Bioscience

Q&A: The novel coronavirus outbreak causing COVID-19

(2020) Dale Fisher et al.   BMC Medicine

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

(2020) Aiping Wu et al.   Cell Host & Microbe

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Return of the Coronavirus: 2019-nCoV

(2020) Lisa E. Gralinski et al.   Viruses-Basel

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

(2020) Jasper Fuk-Woo Chan et al.   Emerging Microbes & Infections

NLRP3 Inflammasome—A Key Player in Antiviral Responses

(2020) Chunyuan Zhao et al.   Frontiers in Immunology

Epidemiology and Clinical Characteristics of COVID-19

(2020) Xiaoyi Huang et al.   Archives of Iranian Medicine

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

A Dynamic Immune Response Shapes COVID-19 Progression

(2020) Eugenia Ziying Ong et al.   Cell Host & Microbe

SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation

(2020) Young-Sheng Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In silico studies on the comparative characterization of the interactions of SARS‐CoV‐2 spike glycoprotein with ACE‐2 receptor homologs and human TLRs

(2020) Abhigyan Choudhury et al.   JOURNAL OF MEDICAL VIROLOGY

Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis

(2020) Francisco Alejandro Lagunas-Rangel   JOURNAL OF MEDICAL VIROLOGY

Genotype and phenotype of COVID-19: Their roles in pathogenesis

(2020) Leila Mousavizadeh et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Regulation of MAVS Expression and Signaling Function in the Antiviral Innate Immune Response

(2020) Zhihua Ren et al.   Frontiers in Immunology

The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

(2020) Yosra A. Helmy et al.   Journal of Clinical Medicine

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

(2020) He-wei Jiang et al.   Cellular & Molecular Immunology

COVID 19: a clue from innate immunity

(2020) Domenico Birra et al.   IMMUNOLOGIC RESEARCH

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

COVID-19 update: The race to therapeutic development

(2020) Julianne D. Twomey et al.   DRUG RESISTANCE UPDATES

The Mitochondrial Outer Membrane Protein Tom70-Mediator in Protein Traffic, Membrane Contact Sites and Innate Immunity

(2020) Sebastian Kreimendahl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

(2020) SangJoon Lee et al.   TRENDS IN IMMUNOLOGY

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2

(2020) Jingfang Mu et al.   Cell Discovery

Detection of Viral Infections by Innate Immunity

(2020) Michael Carty et al.   BIOCHEMICAL PHARMACOLOGY

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

(2020) Tamara S. Rodrigues et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural insights into SARS-CoV-2 proteins

(2020) Rimanshee Arya et al.   JOURNAL OF MOLECULAR BIOLOGY

SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production

(2020) Keli Chen et al.   Viruses-Basel

SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development

(2020) Mei-Yue Wang et al.   Frontiers in Cellular and Infection Microbiology

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

(2019) Weina Zhang et al.   CELL

Interferon-Stimulated Genes: What Do They All Do?

(2019) John W. Schoggins   Annual Review of Virology

Stimulation of Innate Immunity by Host and Viral RNAs

(2019) Felix Streicher et al.   TRENDS IN IMMUNOLOGY

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Innate Immunity Evasion by Enteroviruses Linked to Epidemic Hand-Foot-Mouth Disease

(2018) Yuefei Jin et al.   Frontiers in Microbiology

TBK1: a new player in ALS linking autophagy and neuroinflammation

(2017) James A. Oakes et al.   Molecular Brain

Type I Interferons as Regulators of Lung Inflammation

(2017) Spyridon Makris et al.   Frontiers in Immunology

E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1

(2016) Guanhua Song et al.   NATURE IMMUNOLOGY

Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections

(2015) Sophia Davidson et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Modulation of NF-κB signalling by microbial pathogens

(2011) Masmudur M. Rahman et al.   NATURE REVIEWS MICROBIOLOGY

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria

(2010) Xin-Yi Liu et al.   CELL RESEARCH