SARS-CoV-2: from its discovery to genome structure, transcription, and replication

Remdesivir in Coronavirus Disease 2019 (COVID-19) treatment: a review of evidence

(2021) Hui Xian Jaime Lin et al.   INFECTION

Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays

(2021) Yash Gupta et al.   METHODS

Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit

(2021) Heiko Slanina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2 spillover events

(2021) Peng Zhou et al.   SCIENCE

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

(2021) Goran Kokic et al.   Nature Communications

The SARS-CoV-2 subgenome landscape and its novel regulatory features

(2021) Dehe Wang et al.   MOLECULAR CELL

Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin

(2021) Wanchao Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease

(2021) Jeremy D. Baker et al.   PLoS One

Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP

(2021) Katerina Naydenova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lessons learned one year after SARS-CoV-2 emergence leading to COVID-19 pandemic

(2021) Kelvin Kai-Wang To et al.   Emerging Microbes & Infections

Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants

(2021) Rui Wang et al.   Communications Biology

Identifying structural–functional analogue of GRL0617, the only well-established inhibitor for papain-like protease (PLpro) of SARS-CoV2 from the pool of fungal metabolites using docking and molecular dynamics simulation

(2021) Priyashi Rao et al.   MOLECULAR DIVERSITY

Meticulous assessment of natural compounds from NPASS database for identifying analogue of GRL0617, the only known inhibitor for SARS-CoV2 papain-like protease (PLpro) using rigorous computational workflow

(2021) Paritosh Parmar et al.   MOLECULAR DIVERSITY

Timing the SARS-CoV-2 index case in Hubei province

(2021) Jonathan Pekar et al.   SCIENCE

Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses

(2021) Hong Zhou et al.   CELL

Coronavirus Infections—More Than Just the Common Cold

(2020) Catharine I. Paules et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

SARS-CoV-2 is an appropriate name for the new coronavirus

(2020) Yuntao Wu et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Another Decade, Another Coronavirus

(2020) Stanley Perlman   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

Structural basis for RNA replication by the SARS-CoV-2 polymerase

(2020) Quan Wang et al.   CELL

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Structure of replicating SARS-CoV-2 polymerase

(2020) Hauke S. Hillen et al.   NATURE

Infection of dogs with SARS-CoV-2

(2020) Thomas H. C. Sit et al.   NATURE

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Transmission of SARS-CoV-2 in Domestic Cats

(2020) Peter J. Halfmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first look

(2020) Ramya Rangan et al.   RNA

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

(2020) Wanchao Yin et al.   SCIENCE

Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from SARS-CoV-2

(2020) Qi Peng et al.   Cell Reports

Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2

(2020) Salvatore Di Giorgio et al.   Science Advances

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex

(2020) James Chen et al.   CELL

The molecular virology of Coronaviruses

(2020) Ella Hartenian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A putative new SARS-CoV protein, 3c, encoded in an ORF overlapping ORF3a

(2020) Andrew E. Firth   JOURNAL OF GENERAL VIROLOGY

Double-Membrane Vesicles as Platforms for Viral Replication

(2020) Georg Wolff et al.   TRENDS IN MICROBIOLOGY

Structural basis of RNA cap modification by SARS-CoV-2

(2020) Thiruselvam Viswanathan et al.   Nature Communications

Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin

(2020) Petra Krafcikova et al.   Nature Communications

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein

(2020) Andrew D. Davidson et al.   Genome Medicine

Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

(2020) Dene R. Littler et al.   iScience

SARS-CoV-2 E protein is a potential ion channel that can be inhibited by Gliclazide and Memantine

(2020) Prabhat Pratap Singh Tomar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The coding capacity of SARS-CoV-2

(2020) Yaara Finkel et al.   NATURE

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GESS: a database of global evaluation of SARS-CoV-2/hCoV-19 sequences

(2020) Shuyi Fang et al.   NUCLEIC ACIDS RESEARCH

Secondary structure of the SARS-CoV-2 5’-UTR

(2020) Zhichao Miao et al.   RNA Biology

From People to Panthera: Natural SARS-CoV-2 Infection in Tigers and Lions at the Bronx Zoo

(2020) Denise McAloose et al.   mBio

SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

(2020) Yoriyuki Konno et al.   Cell Reports

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

(2020) Liming Yan et al.   CELL

Structural insights into SARS-CoV-2 proteins

(2020) Rimanshee Arya et al.   JOURNAL OF MOLECULAR BIOLOGY

The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2

(2020) Omer Ziv et al.   MOLECULAR CELL

COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far

(2020) Mujeeb Khan et al.   MOLECULES

Translational control of coronaviruses

(2020) Sylvain de Breyne et al.   NUCLEIC ACIDS RESEARCH

Dysregulation of Cell Signaling by SARS-CoV-2

(2020) Rahul K. Suryawanshi et al.   TRENDS IN MICROBIOLOGY

The RNA Architecture of the SARS-CoV-2 3′-Untranslated Region

(2020) Junxing Zhao et al.   Viruses-Basel

Architecture of a SARS-CoV-2 mini replication and transcription complex

(2020) Liming Yan et al.   Nature Communications

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

(2020) Steffen Klein et al.   Nature Communications

Programmed −1 Ribosomal Frameshifting in coronaviruses: A therapeutic target

(2020) Jamie A. Kelly et al.   VIROLOGY

Identification and characterization of a human coronavirus 229E nonstructural protein 8-associated RNA 3′-terminal adenylyltransferase activity

(2019) Jana Tvarogová et al.   JOURNAL OF VIROLOGY

Tales of Detailed Poly(A) Tails

(2018) Angela L. Nicholson et al.   TRENDS IN CELL BIOLOGY

Expanded subgenomic mRNA transcriptome and coding capacity of a nidovirus

(2017) Han Di et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Characterization of a Ribose 2′-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales

(2016) Cong Zeng et al.   JOURNAL OF VIROLOGY

Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus Polyadenylation

(2016) Yu-Hui Peng et al.   PLoS One

Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex

(2015) Yuanyuan Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Importance of Virology at a Time of Great Need and Great Jeopardy

(2015) Michael J. Imperiale et al.   mBio

Continuous and Discontinuous RNA Synthesis in Coronaviruses

(2015) Isabel Sola et al.   Annual Review of Virology

Accessory proteins of SARS-CoV and other coronaviruses

(2014) Ding Xiang Liu et al.   ANTIVIRAL RESEARCH

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

(2014) Lorenzo Subissi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of coronaviral poly(A) tail length during infection is not coronavirus species- or host cell-specific

(2014) Jui-Hung Shien et al.   VIRUS GENES

RNA structure analysis of alphacoronavirus terminal genome regions

(2014) Ramakanth Madhugiri et al.   VIRUS RESEARCH

Is Virology Dead?

(2014) D. DiMaio   mBio

Emergence of MERS-CoV in the Middle East: Origins, Transmission, Treatment, and Perspectives

(2014) Ahmad Sharif-Yakan et al.   PLoS Pathogens

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

(2013) R. J. de Groot et al.   JOURNAL OF VIROLOGY

Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study

(2013) Chantal BEM Reusken et al.   LANCET INFECTIOUS DISEASES

Regulation of Coronaviral Poly(A) Tail Length during Infection

(2013) Hung-Yi Wu et al.   PLoS One

Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus

(2012) P. C. Y. Woo et al.   JOURNAL OF VIROLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

(2012) M. Bouvet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subgenomic messenger RNA amplification in coronaviruses

(2010) H.-Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation

(2010) Mickaël Bouvet et al.   PLoS Pathogens

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA