Disassembling the Nature of Capsid: Biochemical, Genetic, and Imaging Approaches to Assess HIV-1 Capsid Functions

Cone-shaped HIV-1 capsids are transported through intact nuclear pores

(2021) Vojtech Zila et al.   CELL

HIV-1 uncoating occurs via a series of rapid biomechanical changes in the core related to individual stages of reverse transcription

(2021) Sanela Rankovic et al.   JOURNAL OF VIROLOGY

HIV-1 cores retain their integrity until minutes before uncoating in the nucleus

(2021) Chenglei Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, Function, and Interactions of the HIV-1 Capsid Protein

(2021) Eric Rossi et al.   Life-Basel

Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

(2021) Zhou Zhong et al.   mBio

HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

(2021) Thorsten G Müller et al.   eLife

HIV-1 Capsid Core: A Bullet to the Heart of the Target Cell

(2021) Elenia Toccafondi et al.   Frontiers in Microbiology

HIV-1 uncoats in the nucleus near sites of integration

(2020) Ryan C. Burdick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensor Sensibility—HIV-1 and the Innate Immune Response

(2020) Xin Yin et al.   Cells

Remodeling of the Core Leads HIV-1 Preintegration Complex into the Nucleus of Human Lymphocytes

(2020) Guillermo Blanco-Rodriguez et al.   JOURNAL OF VIROLOGY

Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core

(2020) Anastasia Selyutina et al.   Cell Reports

TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner

(2020) Molly Ohainle et al.   PLoS Pathogens

Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus

(2020) Adarsh Dharan et al.   Nature Microbiology

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

(2020) Ashwanth C. Francis et al.   Nature Communications

Disrupting HIV ‐1 capsid formation causes cGAS sensing of viral DNA

(2020) Rebecca P Sumner et al.   EMBO JOURNAL

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

(2020) Chaoyi Xu et al.   PLOS BIOLOGY

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the Nuclear Pore Complex

(2019) David Alejandro Bejarano et al.   eLife

CA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity Phenotypes

(2019) Douglas K. Fischer et al.   JOURNAL OF VIROLOGY

Maturation of retroviruses

(2019) Owen Pornillos et al.   Current Opinion in Virology

Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms

(2019) Brady J. Summers et al.   Cell Host & Microbe

FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking

(2019) Pei-Tzu Huang et al.   Cell Reports

Kinesin and dynein use distinct mechanisms to bypass obstacles

(2019) Luke S Ferro et al.   eLife

Cyclophilin A protects HIV-1 from restriction by human TRIM5α

(2019) Kyusik Kim et al.   Nature Microbiology

Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport

(2018) Ashwanth C. Francis et al.   Cell Host & Microbe

Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid

(2018) Jiying Ning et al.   JOURNAL OF VIROLOGY

Live-Cell Imaging of Early Steps of Single HIV-1 Infection

(2018) Ashwanth Francis et al.   Viruses-Basel

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis

(2018) Chantal L Márquez et al.   eLife

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

(2018) Donna L Mallery et al.   eLife

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

(2018) Vasudevan Achuthan et al.   Cell Host & Microbe

HIV-1 Engages a Dynein-Dynactin-BICD2 Complex for Infection and Transport to the Nucleus

(2018) Stephanie K. Carnes et al.   JOURNAL OF VIROLOGY

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

(2018) Melissa Kane et al.   eLife

Imaging HIV-1 Genomic DNA from Entry through Productive Infection

(2017) Ryan D. Stultz et al.   JOURNAL OF VIROLOGY

Reverse Transcription Mechanically Initiates HIV-1 Capsid Disassembly

(2017) Sanela Rankovic et al.   JOURNAL OF VIROLOGY

Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport

(2017) Michael Keegan Delaney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection

(2017) Adarsh Dharan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early cytoplasmic uncoating is associated with infectivity of HIV-1

(2017) João I. Mamede et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage and polyadenylation: Ending the message expands gene regulation

(2017) Jonathan Neve et al.   RNA Biology

Capsid-Dependent Host Factors in HIV-1 Infection

(2017) Masahiro Yamashita et al.   TRENDS IN MICROBIOLOGY

Physical properties of the HIV-1 capsid from all-atom molecular dynamics simulations

(2017) Juan R. Perilla et al.   Nature Communications

Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating

(2017) Viacheslav Malikov et al.   Cell Reports

Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes

(2017) Ryan C. Burdick et al.   PLoS Pathogens

Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus PassageIn Vivo

(2016) Akatsuki Saito et al.   JOURNAL OF VIROLOGY

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

(2016) David A. Jacques et al.   NATURE

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

(2016) Gregory A. Sowd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription

(2016) Ophélie Cosnefroy et al.   Retrovirology

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells

(2016) Ashwanth C. Francis et al.   PLoS Pathogens

KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection

(2016) Adarsh Dharan et al.   PLoS Pathogens

HIV-1 capsid: the multifaceted key player in HIV-1 infection

(2015) Edward M. Campbell et al.   NATURE REVIEWS MICROBIOLOGY

HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus

(2015) Viacheslav Malikov et al.   Nature Communications

Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration

(2015) Christopher R. Chin et al.   Cell Reports

Identification of Capsid Mutations That Alter the Rate of HIV-1 Uncoating in Infected Cells

(2014) Amy E. Hulme et al.   JOURNAL OF VIROLOGY

HIV-1 Uncoating Is Facilitated by Dynein and Kinesin 1

(2014) Z. Lukic et al.   JOURNAL OF VIROLOGY

Structural basis for nuclear import of splicing factors by human Transportin 3

(2014) G. N. Maertens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic Dynein Promotes HIV-1 Uncoating

(2014) Paulina Pawlica et al.   Viruses-Basel

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

(2014) Amanda J. Price et al.   PLoS Pathogens

A Cyclophilin Homology Domain-Independent Role for Nup358 in HIV-1 Infection

(2014) Anne M. Meehan et al.   PLoS Pathogens

Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid

(2014) Ke Peng et al.   eLife

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

(2013) Xavier Lahaye et al.   IMMUNITY

Structural and Functional Analysis of the C-Terminal Domain of Nup358/RanBP2

(2013) Daniel H. Lin et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358

(2013) Katsiaryna Bichel et al.   Retrovirology

The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6

(2013) Thomas Fricke et al.   Retrovirology

Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay

(2013) Hongzhan Xu et al.   Retrovirology

TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm

(2013) Alberto De Iaco et al.   Retrovirology

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication

(2013) Francesca Di Nunzio et al.   VIROLOGY

Extreme Genetic Fragility of the HIV-1 Capsid

(2013) Suzannah J. Rihn et al.   PLoS Pathogens

Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity

(2013) Kenneth A. Matreyek et al.   PLoS Pathogens

Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection

(2012) Zandrea Ambrose et al.   JOURNAL OF VIROLOGY

TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core

(2012) J. C. Valle-Casuso et al.   JOURNAL OF VIROLOGY

Human Nucleoporins Promote HIV-1 Docking at the Nuclear Pore, Nuclear Import and Integration

(2012) Francesca Di Nunzio et al.   PLoS One

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin

(2012) B. Zakeri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

(2012) Amanda J. Price et al.   PLoS Pathogens

The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral Capsid

(2011) K. A. Matreyek et al.   JOURNAL OF VIROLOGY

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription

(2011) A. E. Hulme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

Flexible Use of Nuclear Import Pathways by HIV-1

(2010) KyeongEun Lee et al.   Cell Host & Microbe

Disulfide Bond Stabilization of the Hexameric Capsomer of Human Immunodeficiency Virus

(2010) Owen Pornillos et al.   JOURNAL OF MOLECULAR BIOLOGY

Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking

(2010) Alan R. Lowe et al.   NATURE

Perturbation of Host Nuclear Membrane Component RanBP2 Impairs the Nuclear Import of Human Immunodeficiency Virus -1 Preintegration Complex (DNA)

(2010) Ruonan Zhang et al.   PLoS One

Hexagonal assembly of a restricting TRIM5  protein

(2010) B. K. Ganser-Pornillos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A B-Box 2 Surface Patch Important for TRIM5  Self-Association, Capsid Binding Avidity, and Retrovirus Restriction

(2009) F. Diaz-Griffero et al.   JOURNAL OF VIROLOGY

Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein

(2009) Felix F. Vajdos et al.   PROTEIN SCIENCE

Transportin-SR2 Imports HIV into the Nucleus

(2008) Frauke Christ et al.   CURRENT BIOLOGY

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE