HIV-1 capsid: the multifaceted key player in HIV-1 infection

HIV suppression by host restriction factors and viral immune evasion

(2015) Xiaofei Jia et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Human Immunodeficiency Virus Type 1 Employs the Cellular Dynein Light Chain 1 Protein for Reverse Transcription through Interaction with Its Integrase Protein

(2015) Kallesh Danappa Jayappa et al.   JOURNAL OF VIROLOGY

HIV-1 and interferons: who's interfering with whom?

(2015) Tomas Doyle et al.   NATURE REVIEWS MICROBIOLOGY

Type I Interferon: Understanding Its Role in HIV Pathogenesis and Therapy

(2015) Steven E. Bosinger et al.   Current HIV/AIDS Reports

Identification of Capsid Mutations That Alter the Rate of HIV-1 Uncoating in Infected Cells

(2014) Amy E. Hulme et al.   JOURNAL OF VIROLOGY

HIV-1 Uncoating Is Facilitated by Dynein and Kinesin 1

(2014) Z. Lukic et al.   JOURNAL OF VIROLOGY

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

(2014) Akash Bhattacharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA

(2014) Alberto De Iaco et al.   Retrovirology

BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid

(2014) Thomas Fricke et al.   Retrovirology

MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1

(2014) Thomas Fricke et al.   Retrovirology

HIV-1 uncoating: connection to nuclear entry and regulation by host proteins

(2014) Zandrea Ambrose et al.   VIROLOGY

Cytoplasmic Dynein Promotes HIV-1 Uncoating

(2014) Paulina Pawlica et al.   Viruses-Basel

A model for cofactor use during HIV-1 reverse transcription and nuclear entry

(2014) Laura Hilditch et al.   Current Opinion in Virology

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

(2014) Amanda J. Price et al.   PLoS Pathogens

A Cyclophilin Homology Domain-Independent Role for Nup358 in HIV-1 Infection

(2014) Anne M. Meehan et al.   PLoS Pathogens

In Vivo Functions of CPSF6 for HIV-1 as Revealed by HIV-1 Capsid Evolution in HLA-B27-Positive Subjects

(2014) Matthew S. Henning et al.   PLoS Pathogens

Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid

(2014) Ke Peng et al.   eLife

Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes

(2013) Louie Lamorte et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HIV-1 Induces the Formation of Stable Microtubules to Enhance Early Infection

(2013) Yosef Sabo et al.   Cell Host & Microbe

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

(2013) Xavier Lahaye et al.   IMMUNITY

A Carboxy-Terminally Truncated Human CPSF6 Lacking Residues Encoded by Exon 6 Inhibits HIV-1 cDNA Synthesis and Promotes Capsid Disassembly

(2013) T. Hori et al.   JOURNAL OF VIROLOGY

Human Cytosolic Extracts Stabilize the HIV-1 Core

(2013) T. Fricke et al.   JOURNAL OF VIROLOGY

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics

(2013) Gongpu Zhao et al.   NATURE

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

(2013) K. A. Jurado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear import of APOBEC3F-labeled HIV-1 preintegration complexes

(2013) R. C. Burdick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358

(2013) Katsiaryna Bichel et al.   Retrovirology

Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay

(2013) Hongzhan Xu et al.   Retrovirology

TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm

(2013) Alberto De Iaco et al.   Retrovirology

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

HIV trafficking in host cells: motors wanted!

(2013) Raphaël Gaudin et al.   TRENDS IN CELL BIOLOGY

Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication

(2013) Francesca Di Nunzio et al.   VIROLOGY

Viruses Challenge Selectivity Barrier of Nuclear Pores

(2013) Aksana Labokha et al.   Viruses-Basel

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

Extreme Genetic Fragility of the HIV-1 Capsid

(2013) Suzannah J. Rihn et al.   PLoS Pathogens

Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity

(2013) Kenneth A. Matreyek et al.   PLoS Pathogens

Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection

(2013) Sebla B. Kutluay et al.   PLoS Pathogens

Identification of Residues in the C-terminal Domain of HIV-1 Integrase That Mediate Binding to the Transportin-SR2 Protein

(2012) Stephanie De Houwer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration

(2012) Livio Azzoni et al.   JOURNAL OF INFECTIOUS DISEASES

Inhibition of Reverse Transcriptase Activity Increases Stability of the HIV-1 Core

(2012) Y. Yang et al.   JOURNAL OF VIROLOGY

HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6

(2012) K. Lee et al.   JOURNAL OF VIROLOGY

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration

(2012) Y. Koh et al.   JOURNAL OF VIROLOGY

TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core

(2012) J. C. Valle-Casuso et al.   JOURNAL OF VIROLOGY

The Host Proteins Transportin SR2/TNPO3 and Cyclophilin A Exert Opposing Effects on HIV-1 Uncoating

(2012) V. B. Shah et al.   JOURNAL OF VIROLOGY

Human Nucleoporins Promote HIV-1 Docking at the Nuclear Pore, Nuclear Import and Integration

(2012) Francesca Di Nunzio et al.   PLoS One

Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects

(2012) Ruifeng Yang et al.   Retrovirology

Intracellular nucleotide levels and the control of retroviral infections

(2012) Sarah M. Amie et al.   VIROLOGY

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

(2012) Amanda J. Price et al.   PLoS Pathogens

Kinesin-1-Mediated Capsid Disassembly and Disruption of the Nuclear Pore Complex Promote Virus Infection

(2011) Sten Strunze et al.   Cell Host & Microbe

The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral Capsid

(2011) K. A. Matreyek et al.   JOURNAL OF VIROLOGY

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription

(2011) A. E. Hulme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus

(2011) Alberto De Iaco et al.   Retrovirology

Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import

(2011) Alexandra Cribier et al.   Retrovirology

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2

(2011) Karen E. Ocwieja et al.   PLoS Pathogens

Transportin 3 Promotes a Nuclear Maturation Step Required for Efficient HIV-1 Integration

(2011) Lihong Zhou et al.   PLoS Pathogens

Flexible Use of Nuclear Import Pathways by HIV-1

(2010) KyeongEun Lee et al.   Cell Host & Microbe

Role of Human Immunodeficiency Virus Type 1 Integrase in Uncoating of the Viral Core

(2010) M. S. Briones et al.   JOURNAL OF VIROLOGY

Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization

(2010) J. Shi et al.   JOURNAL OF VIROLOGY

Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking

(2010) Alan R. Lowe et al.   NATURE

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

The nuclear pore complex: bridging nuclear transport and gene regulation

(2010) Caterina Strambio-De-Castillia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perturbation of Host Nuclear Membrane Component RanBP2 Impairs the Nuclear Import of Human Immunodeficiency Virus -1 Preintegration Complex (DNA)

(2010) Ruonan Zhang et al.   PLoS One

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

(2010) Wade S. Blair et al.   PLoS Pathogens

Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function

(2009) In-Ja L. Byeon et al.   CELL

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

(2009) Owen Pornillos et al.   CELL

The Requirement for Cellular Transportin 3 (TNPO3 or TRN-SR2) during Infection Maps to Human Immunodeficiency Virus Type 1 Capsid and Not Integrase

(2009) L. Krishnan et al.   JOURNAL OF VIROLOGY

Target Cell Type-Dependent Modulation of Human Immunodeficiency Virus Type 1 Capsid Disassembly by Cyclophilin A

(2009) Y. Li et al.   JOURNAL OF VIROLOGY

Mammalian pre-mRNA 3′ End Processing Factor CF Im68 Functions in mRNA Export

(2009) Marc-David Ruepp et al.   MOLECULAR BIOLOGY OF THE CELL

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

(2008) Renate König et al.   CELL

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

(2008) Honglin Zhou et al.   Cell Host & Microbe

Transportin-SR2 Imports HIV into the Nucleus

(2008) Frauke Christ et al.   CURRENT BIOLOGY

Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5α

(2008) Edward M. Campbell et al.   JOURNAL OF CELL BIOLOGY

Cyclophilin A Levels Dictate Infection Efficiency of Human Immunodeficiency Virus Type 1 Capsid Escape Mutants A92E and G94D

(2008) L. M. J. Ylinen et al.   JOURNAL OF VIROLOGY

Cyclophilin A-Dependent Restriction of Human Immunodeficiency Virus Type 1 Capsid Mutants for Infection of Nondividing Cells

(2008) M. Qi et al.   JOURNAL OF VIROLOGY

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE