TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the Nuclear Pore Complex

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Immunoproteasome activation enables human TRIM5α restriction of HIV-1

(2019) Jose M. Jimenez-Guardeño et al.   Nature Microbiology

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

(2018) Vasudevan Achuthan et al.   Cell Host & Microbe

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

(2018) Melissa Kane et al.   eLife

Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

(2018) Sean Matthew McCauley et al.   Nature Communications

A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

(2018) Molly OhAinle et al.   eLife

Complex Interplay between HIV-1 Capsid and MX2-Independent Alpha Interferon-Induced Antiviral Factors

(2016) Lorenzo Bulli et al.   JOURNAL OF VIROLOGY

Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus PassageIn Vivo

(2016) Akatsuki Saito et al.   JOURNAL OF VIROLOGY

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

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HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry

(2015) Jing Zhou et al.   JOURNAL OF VIROLOGY

HIV-1 capsid: the multifaceted key player in HIV-1 infection

(2015) Edward M. Campbell et al.   NATURE REVIEWS MICROBIOLOGY

The highly polymorphic cyclophilin A-binding loop in HIV-1 capsid modulates viral resistance to MxB

(2015) Zhenlong Liu et al.   Retrovirology

Identification of Capsid Mutations That Alter the Rate of HIV-1 Uncoating in Infected Cells

(2014) Amy E. Hulme et al.   JOURNAL OF VIROLOGY

Host and Viral Determinants of Mx2 Antiretroviral Activity

(2014) Idoia Busnadiego et al.   JOURNAL OF VIROLOGY

HIV-1 uncoating: connection to nuclear entry and regulation by host proteins

(2014) Zandrea Ambrose et al.   VIROLOGY

A model for cofactor use during HIV-1 reverse transcription and nuclear entry

(2014) Laura Hilditch et al.   Current Opinion in Virology

In Vivo Functions of CPSF6 for HIV-1 as Revealed by HIV-1 Capsid Evolution in HLA-B27-Positive Subjects

(2014) Matthew S. Henning et al.   PLoS Pathogens

The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection

(2013) Zhenlong Liu et al.   Cell Host & Microbe

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

MX2 is an interferon-induced inhibitor of HIV-1 infection

(2013) Melissa Kane et al.   NATURE

Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction

(2013) Yang Yang et al.   VIROLOGY

HIV Restriction Factors and Mechanisms of Evasion

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Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection

(2012) Zandrea Ambrose et al.   JOURNAL OF VIROLOGY

The Host Proteins Transportin SR2/TNPO3 and Cyclophilin A Exert Opposing Effects on HIV-1 Uncoating

(2012) V. B. Shah et al.   JOURNAL OF VIROLOGY

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

(2012) Amanda J. Price et al.   PLoS Pathogens

Determinants of the Higher Order Association of the Restriction Factor TRIM5α and Other Tripartite Motif (TRIM) Proteins

(2011) Xing Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus

(2011) Alberto De Iaco et al.   Retrovirology

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

Flexible Use of Nuclear Import Pathways by HIV-1

(2010) KyeongEun Lee et al.   Cell Host & Microbe

Safety, Tolerability, and Mechanisms of Antiretroviral Activity of Pegylated Interferon Alfa‐2a in HIV‐1–Monoinfected Participants: A Phase II Clinical Trial

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HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

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