Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

Capsid labelled HIV to investigate the role of capsid during nuclear import and integration

(2020) Irena Zurnic Bönisch et al.   JOURNAL OF VIROLOGY

HIV-1 uncoats in the nucleus near sites of integration

(2020) Ryan C. Burdick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorogen activating protein toolset for protein trafficking measurements

(2020) Lydia A. Perkins et al.   TRAFFIC

Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core

(2020) Anastasia Selyutina et al.   Cell Reports

TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner

(2020) Molly Ohainle et al.   PLoS Pathogens

Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus

(2020) Adarsh Dharan et al.   Nature Microbiology

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

(2020) Ashwanth C. Francis et al.   Nature Communications

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the Nuclear Pore Complex

(2019) David Alejandro Bejarano et al.   eLife

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

(2019) Sooin Jang et al.   NUCLEIC ACIDS RESEARCH

Cyclophilin A protects HIV-1 from restriction by human TRIM5α

(2019) Kyusik Kim et al.   Nature Microbiology

Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport

(2018) Ashwanth C. Francis et al.   Cell Host & Microbe

The Role of Microtubules and Microtubule Associated Proteins in HIV-1 Infection

(2018) Adarsh Dharan et al.   JOURNAL OF VIROLOGY

Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid

(2018) Jiying Ning et al.   JOURNAL OF VIROLOGY

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

(2018) Vasudevan Achuthan et al.   Cell Host & Microbe

Capsid-Dependent Host Factors in HIV-1 Infection

(2017) Masahiro Yamashita et al.   TRENDS IN MICROBIOLOGY

Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating

(2017) Viacheslav Malikov et al.   Cell Reports

Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes

(2017) Ryan C. Burdick et al.   PLoS Pathogens

Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus PassageIn Vivo

(2016) Akatsuki Saito et al.   JOURNAL OF VIROLOGY

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

(2016) Gregory A. Sowd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway

(2016) Jiying Ning et al.   Nature Communications

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells

(2016) Ashwanth C. Francis et al.   PLoS Pathogens

HIV-1 capsid: the multifaceted key player in HIV-1 infection

(2015) Edward M. Campbell et al.   NATURE REVIEWS MICROBIOLOGY

Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration

(2015) Christopher R. Chin et al.   Cell Reports

HIV-1 Uncoating Is Facilitated by Dynein and Kinesin 1

(2014) Z. Lukic et al.   JOURNAL OF VIROLOGY

Bidirectional cargo transport: moving beyond tug of war

(2014) William O. Hancock   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for nuclear import of splicing factors by human Transportin 3

(2014) G. N. Maertens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA

(2014) Alberto De Iaco et al.   Retrovirology

HIV-1 uncoating: connection to nuclear entry and regulation by host proteins

(2014) Zandrea Ambrose et al.   VIROLOGY

Cytoplasmic Dynein Promotes HIV-1 Uncoating

(2014) Paulina Pawlica et al.   Viruses-Basel

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

(2014) Amanda J. Price et al.   PLoS Pathogens

In Vivo Functions of CPSF6 for HIV-1 as Revealed by HIV-1 Capsid Evolution in HLA-B27-Positive Subjects

(2014) Matthew S. Henning et al.   PLoS Pathogens

Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid

(2014) Ke Peng et al.   eLife

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics

(2013) Gongpu Zhao et al.   NATURE

The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6

(2013) Thomas Fricke et al.   Retrovirology

Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay

(2013) Hongzhan Xu et al.   Retrovirology

TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm

(2013) Alberto De Iaco et al.   Retrovirology

Extreme Genetic Fragility of the HIV-1 Capsid

(2013) Suzannah J. Rihn et al.   PLoS Pathogens

Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity

(2013) Kenneth A. Matreyek et al.   PLoS Pathogens

Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection

(2012) Zandrea Ambrose et al.   JOURNAL OF VIROLOGY

Protease Cleavage Leads to Formation of Mature Trimer Interface in HIV-1 Capsid

(2012) Xin Meng et al.   PLoS Pathogens

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

(2012) Amanda J. Price et al.   PLoS Pathogens

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

Flexible Use of Nuclear Import Pathways by HIV-1

(2010) KyeongEun Lee et al.   Cell Host & Microbe

Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function

(2009) In-Ja L. Byeon et al.   CELL

Cyclophilin A-Dependent Restriction of Human Immunodeficiency Virus Type 1 Capsid Mutants for Infection of Nondividing Cells

(2008) M. Qi et al.   JOURNAL OF VIROLOGY