The elegant complexity of mammalian ecto-5′-nucleotidase (CD73)

CD73 or CD39 Deletion Reveals Different Mechanisms of Formation for Spontaneous and Mechanically Stimulated Adenosine and Sex Specific Compensations in ATP Degradation

(2020) Ying Wang et al.   ACS Chemical Neuroscience

The circular RNA NT5E promotes non-small cell lung cancer cell growth via sponging microRNA-134

(2020) Lingyun Dong et al.   Aging-US

MicroRNA‐30a suppresses self‐renewal and tumorigenicity of glioma stem cells by blocking the NT5E‐dependent Akt signaling pathway

(2020) Lilei Peng et al.   FASEB JOURNAL

2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5′-nucleotidase (CD73) Inhibitors with Variable Binding Modes

(2020) Sanjay Bhattarai et al.   JOURNAL OF MEDICINAL CHEMISTRY

CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint

(2020) Miao Yu et al.   Nature Communications

Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease

(2020) William J. Moorhead et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Radiolabeled Human Monoclonal Antibody 067-213 has the Potential for Noninvasive Quantification of CD73 Expression

(2020) Hitomi Sudo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73

(2020) Joel W. Beatty et al.   JOURNAL OF MEDICINAL CHEMISTRY

Different subpopulations of kidney interstitial cells produce erythropoietin and factors supporting tissue oxygenation in response to hypoxia in vivo.

(2020) Katharina A.E. Broeker et al.   KIDNEY INTERNATIONAL

Construction of a human cell landscape at single-cell level

(2020) Xiaoping Han et al.   NATURE

Sex-associated molecular differences for cancer immunotherapy

(2020) Youqiong Ye et al.   Nature Communications

Targeting CD73 to augment cancer immunotherapy

(2020) Meejeon Roh et al.   CURRENT OPINION IN PHARMACOLOGY

Discovery of AB680: A Potent and Selective Inhibitor of CD73

(2020) Kenneth V. Lawson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural cells are key regulators of organ-specific immune responses

(2020) Thomas Krausgruber et al.   NATURE

The adenosine pathway in immuno-oncology

(2020) Bertrand Allard et al.   Nature Reviews Clinical Oncology

Impaired estrogen signaling underlies regulatory T cell loss-of-function in the chronically inflamed intestine

(2020) Wendy A. Goodman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

(2020) Lukas F. Mager et al.   SCIENCE

Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor

(2020) Nami Kitajima et al.   eLife

Structural and Functional Characterization of Engineered Bifunctional Fusion Proteins of CD39 and CD73 Ectonucleotidases.

(2020) Elizabeth H. Zhong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Quantitative Proteome Map of the Human Body

(2020) Lihua Jiang et al.   CELL

Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production

(2020) Xiaohui Du et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dual mechanisms of novel CD73-targeted antibody and antibody-drug conjugate in inhibiting lung tumor growth and promoting antitumor immune-effector function

(2020) Rui Jin et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic effects of adenosine in high flow 21% oxygen aereosol in patients with Covid19-pneumonia

(2020) Pierpaolo Correale et al.   PLoS One

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling

(2020) Denis Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescent Probes for Ecto-5′-nucleotidase (CD73)

(2020) Constanze C. Schmies et al.   ACS Medicinal Chemistry Letters

Liver dysfunction is associated with poor prognosis in patients after immune checkpoint inhibitor therapy

(2020) Keisuke Yokohama et al.   Scientific Reports

A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms

(2020) James E. Stefano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ectonucleoside triphosphate diphosphohydrolases and ecto-5′-nucleotidase in purinergic signaling: how the field developed and where we are now

(2020) Herbert Zimmermann   Purinergic Signalling

History of ectonucleotidases and their role in purinergic signaling

(2020) Herbert Zimmermann   BIOCHEMICAL PHARMACOLOGY

Physiology and effects of nucleosides in mice lacking all four adenosine receptors

(2019) Cuiying Xiao et al.   PLOS BIOLOGY

Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development

(2019) Kenneth A. Jacobson et al.   Frontiers in Cellular Neuroscience

The distinct role of CD73 in the progression of pancreatic cancer

(2019) Liangjing Zhou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

CD73 (Cluster of Differentiation 73) and the Differences Between Mice and Humans

(2019) Pouya Joolharzadeh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping

(2019) Nicolas Severe et al.   Cell Stem Cell

Generation and Function of Non-cell-bound CD73 in Inflammation

(2019) Enja Schneider et al.   Frontiers in Immunology

Cell type- and tissue-specific functions of ecto-5'-nucleotidase (CD73)

(2019) Marquet Minor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Estrogen receptors modulate ectonucleotidases activity in hippocampal synaptosomes of male rats

(2019) Nataša Mitrović et al.   NEUROSCIENCE LETTERS

CD73 Promotes Age-Dependent Accretion of Atherosclerosis

(2019) Nadia R. Sutton et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adenosine Metabolism: Emerging Concepts for Cancer Therapy

(2019) Detlev Boison et al.   CANCER CELL

CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment

(2019) Shi Yong Neo et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

(2019) Sangeeta Goswami et al.   NATURE MEDICINE

CircNT5E acts as a sponge of microRNA-422a to promote glioblastoma tumorigenesis

(2018) Renjie Wang et al.   CANCER RESEARCH

In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche

(2018) Martin Breitbach et al.   Cell Stem Cell

Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors

(2018) Eleonora De Martin et al.   JOURNAL OF HEPATOLOGY

The Hypoxia–Adenosine Link during Intestinal Inflammation

(2018) Jessica L. Bowser et al.   JOURNAL OF IMMUNOLOGY

Cancer immunotherapy efficacy and patients' sex: a systematic review and meta-analysis

(2018) Fabio Conforti et al.   LANCET ONCOLOGY

Pharmacology of Adenosine Receptors: The State of the Art

(2018) Pier Andrea Borea et al.   PHYSIOLOGICAL REVIEWS

Who Is Who in Adenosine Transport

(2018) Marçal Pastor-Anglada et al.   Frontiers in Pharmacology

Controlling the Immune Suppressor: Transcription Factors and MicroRNAs Regulating CD73/NT5E

(2018) Theresa Kordaß et al.   Frontiers in Immunology

Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis

(2018) Andreas E. Moor et al.   CELL

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment

(2018) Jie Lan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-type-specific CD73 expression is an independent prognostic factor in bladder cancer

(2018) Maarit K Koivisto et al.   CARCINOGENESIS

Multiple steps determine CD73 shedding from RPE: lipid raft localization, ARA1 interaction, and MMP-9 up-regulation

(2018) Wei Zhang et al.   Purinergic Signalling

Calcification of joints and arteries with novel NT5E mutations with involvement of upper extremity arteries

(2017) Kenji Yoshioka et al.   VASCULAR MEDICINE

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

(2017) Yiming Xu et al.   Nature Communications

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians

(2017) Almudena Crooke et al.   Immunity & Ageing

CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer

(2017) Jieyao Li et al.   OncoImmunology

Proximal Tubule CD73 Is Critical in Renal Ischemia-Reperfusion Injury Protection

(2016) Sun-sang J. Sung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

17β-Estradiol upregulates ecto-5′-nucleotidase (CD73) in hippocampal synaptosomes of female rats through action mediated by estrogen receptor-α and -β

(2016) N. Mitrović et al.   NEUROSCIENCE

Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC

(2016) H. Jin et al.   Science Signaling

Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?

(2016) Pier Andrea Borea et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC

(2016) H. Jin et al.   Science Signaling

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer

(2015) Marian S. Wettstein et al.   DISEASE MARKERS

Loss of CD73-mediated actin polymerization promotes endometrial tumor progression

(2015) Jessica L. Bowser et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcification of joints and arteries: second report with novel NT5E mutations and expansion of the phenotype

(2015) Zeng Zhang et al.   JOURNAL OF HUMAN GENETICS

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection

(2014) Stephen M. Hatfield et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73)

(2014) Natasha T. Snider et al.   MOLECULAR BIOLOGY OF THE CELL

CD73 (ecto-5′-nucleotidase) hepatocyte levels differ across mouse strains and contribute to mallory-denk body formation

(2013) Natasha T. Snider et al.   HEPATOLOGY

Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors

(2013) Paul A. Beavis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signalling and cancer

(2013) Geoffrey Burnstock et al.   Purinergic Signalling

Activated hepatic stellate cells upregulate transcription of ecto-5′-nucleotidase/CD73 via specific SP1 and SMAD promoter elements

(2012) Michel Fausther et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7receptors

(2012) Jingsheng Xia et al.   JOURNAL OF PHYSIOLOGY-LONDON

Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling

(2012) Karen Knapp et al.   STRUCTURE

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

(2012) Akio Ohta et al.   Frontiers in Immunology

CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis

(2011) J. Stagg et al.   CANCER RESEARCH

Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells

(2011) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

NT5EMutations and Arterial Calcifications

(2011) Cynthia St. Hilaire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular adenosine triphosphate and adenosine in cancer

(2010) J Stagg et al.   ONCOGENE

Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation

(2010) R. Corriden et al.   Science Signaling

A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments

(2009) A. Ohta et al.   JOURNAL OF IMMUNOLOGY

Extracellular Adenosine Production by Ecto-5′-Nucleotidase Protects During Murine Hepatic Ischemic Preconditioning

(2008) Melanie L. Hart et al.   GASTROENTEROLOGY

Dynamics of shear-induced ATP release from red blood cells

(2008) J. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA