A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms

Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

(2019) Ivan Perrot et al.   Cell Reports

An Exceptionally Potent Inhibitor of Human CD73

(2019) Christine E. Bowman et al.   BIOCHEMISTRY

Role of CD73 in Disease: Promising Prognostic Indicator and Therapeutic Target

(2018) Jiayin Yang et al.   CURRENT MEDICINAL CHEMISTRY

Targeting the CD73-adenosine axis in immuno-oncology

(2018) David Allard et al.   IMMUNOLOGY LETTERS

Targeting adenosine for cancer immunotherapy

(2018) Robert D. Leone et al.   Journal for ImmunoTherapy of Cancer

Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers

(2018) Lisa Seitz et al.   INVESTIGATIONAL NEW DRUGS

CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells

(2018) Kerstin Schütze et al.   Frontiers in Immunology

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases

(2017) Dipti Vijayan et al.   OncoImmunology

Antibodies Targeting Closely Adjacent or Minimally Overlapping Epitopes Can Displace One Another

(2017) Yasmina Noubia Abdiche et al.   PLoS One

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy

(2016) John Y. Li et al.   CANCER CELL

CD73–adenosine: a next-generation target in immuno-oncology

(2016) David Allard et al.   Immunotherapy

Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action

(2016) James C. Geoghegan et al.   mAbs

Targeting CD73 in the tumor microenvironment with MEDI9447

(2016) Carl M. Hay et al.   OncoImmunology

Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling

(2015) Filippa Fleetwood et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Controlled Fab-arm exchange for the generation of stable bispecific IgG1

(2014) Aran F Labrijn et al.   Nature Protocols

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Anti-Human CD73 Monoclonal Antibody Inhibits Metastasis Formation in Human Breast Cancer by Inducing Clustering and Internalization of CD73 Expressed on the Surface of Cancer Cells

(2013) M. G. Terp et al.   JOURNAL OF IMMUNOLOGY

Production of stable bispecific IgG1 by controlled Fab-arm exchange

(2013) Michael J Gramer et al.   mAbs

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

(2013) A. F. Labrijn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2

(2013) Christian Jost et al.   STRUCTURE

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

Crystal Structure of a Soluble Form of Human CD73 with Ecto-5′-Nucleotidase Activity

(2012) Dominic P. H. M. Heuts et al.   CHEMBIOCHEM

Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling

(2012) Karen Knapp et al.   STRUCTURE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Studies of the Extracellular ATP-Adenosine Pathway in Human Urinary Tract Epithelial Cells

(2009) Camilla Mohlin et al.   PHARMACOLOGY

Exploring blocking assays using Octet, ProteOn, and Biacore biosensors

(2008) Yasmina N. Abdiche et al.   ANALYTICAL BIOCHEMISTRY