CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment

CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy

(2019) Siqi Chen et al.   Nature Communications

Human dental pulp stem cells regulate allogeneic NK cells’ function via induction of anti‐inflammatory purinergic signalling in activated NK cells

(2019) Fei Yan et al.   CELL PROLIFERATION

Comprehensive evaluation of NT5E/CD73 expression and its prognostic significance in distinct types of cancers

(2018) Tao Jiang et al.   BMC CANCER

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

(2018) Tammy Linlin Song et al.   BLOOD

Exosomes in HNSCC plasma as surrogate markers of tumour progression and immune competence

(2018) M.-N. Theodoraki et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Soluble CD73 as biomarker in patients with metastatic melanoma patients treated with nivolumab

(2017) Silvana Morello et al.   Journal of Translational Medicine

Adenosine checkpoint agent blazes a trail, joins immunotherapy roster

(2017) Ken Garber   NATURE BIOTECHNOLOGY

A distinct innate lymphoid cell population regulates tumor-associated T cells

(2017) Sarah Q Crome et al.   NATURE MEDICINE

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

(2017) Scott Gettinger et al.   Cancer Discovery

Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer

(2017) Yusuke Inoue et al.   Oncotarget

Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases

(2017) Dipti Vijayan et al.   OncoImmunology

A prognostic risk model for patients with triple negative breast cancer based on stromal natural killer cells, tumor-associated macrophages and growth-arrest specific protein 6

(2016) Wenjing Tian et al.   CANCER SCIENCE

CD73–adenosine: a next-generation target in immuno-oncology

(2016) David Allard et al.   Immunotherapy

Preclinical Characterization of 3β-(N-Acetyl l-cysteine methyl ester)-2aβ,3-dihydrogaliellalactone (GPA512), a Prodrug of a Direct STAT3 Inhibitor for the Treatment of Prostate Cancer

(2016) Zilma Escobar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Regulation of Natural Killer Cell Function by STAT3

(2016) Nicholas A. Cacalano   Frontiers in Immunology

CD56brightCD16−NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+T Cell Proliferation

(2015) Fabio Morandi et al.   JOURNAL OF IMMUNOLOGY

Natural Killer Cell-Based Therapies Targeting Cancer: Possible Strategies to Gain and Sustain Anti-Tumor Activity

(2015) Carin I. M. Dahlberg et al.   Frontiers in Immunology

Natural killer cells acquire CD73 expression upon exposure to mesenchymal stem cells

(2014) D. Chatterjee et al.   BLOOD

Human CD4+CD39+regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+exosomes or CD73+cells

(2014) P. J. Schuler et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Galiellalactone Is a Direct Inhibitor of the Transcription Factor STAT3 in Prostate Cancer Cells

(2014) Nicholas Don-Doncow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Stat3 promotes IL-10 expression in lupus T cells throughtrans-activation and chromatin remodeling

(2014) Christian M. Hedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse Mechanisms Regulate the Surface Expression of Immunotherapeutic Target CTLA-4

(2014) Helga Schneider et al.   Frontiers in Immunology

Purinergic receptors and nucleotide processing ectoenzymes: Their roles in regulating mesenchymal stem cell functions

(2014) Sonia Scarfì   World Journal of Stem Cells

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+T cells contributes to their regulatory function

(2013) Lesley Ann Smyth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

(2013) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Intracellular Antiviral Defense Mechanisms Augments Lentiviral Transduction of Human Natural Killer Cells: Implications for Gene Therapy

(2012) Tolga Sutlu et al.   HUMAN GENE THERAPY

Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression

(2012) Fanny Chalmin et al.   IMMUNITY

Role of mesenchymal stem cells in reestablishing immunologic tolerance in autoimmune rheumatic diseases

(2011) Gordon I. A. MacDonald et al.   ARTHRITIS AND RHEUMATISM

Mesenchymal stromal cells up-regulate CD39 and increase adenosine production to suppress activated T-lymphocytes

(2011) Felipe Saldanha-Araujo et al.   Stem Cell Research

Peripheral 4-1BB Signaling Negatively Regulates NK Cell Development through IFN- 

(2010) B. K. Choi et al.   JOURNAL OF IMMUNOLOGY

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory Natural Killer Cells: New Players in the IL-10 Anti-Inflammatory Response

(2009) Eric Vivier et al.   Cell Host & Microbe

Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection

(2009) Seung-Hwan Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Natural killer cell recognition of missing self

(2008) Klas Kärre   NATURE IMMUNOLOGY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY