Synthetic biology applications of the yeast mating signal pathway

A fluorescence‐based yeast sensor for monitoring acetic acid

(2021) Katja Hahne et al.   ENGINEERING IN LIFE SCIENCES

Programmable protein circuit design

(2021) Zibo Chen et al.   CELL

Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease

(2021) Benjamin M. Scott et al.   NATURE MEDICINE

A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions

(2021) Ravi V. Desai et al.   SCIENCE

Engineering yeast artificial core promoter with designated base motifs

(2020) Rui Liu et al.   Microbial Cell Factories

Improved protein structure prediction using potentials from deep learning

(2020) Andrew W. Senior et al.   NATURE

Designing Synthetic Microbial Consortia for Biofuel Production

(2020) Yujia Jiang et al.   TRENDS IN BIOTECHNOLOGY

Conjugated Protein Domains as Engineered Scaffold Proteins

(2020) Lenne J. M. Lemmens et al.   BIOCONJUGATE CHEMISTRY

Model-driven generation of artificial yeast promoters

(2020) Benjamin J. Kotopka et al.   Nature Communications

Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast

(2020) Frank Van Drogen et al.   CELL CYCLE

Promoter Architecture and Promoter Engineering in Saccharomyces cerevisiae

(2020) Hongting Tang et al.   Metabolites

Yeast-Based Biosensors: Current Applications and New Developments

(2020) Helene Martin-Yken   Biosensors-Basel

Asymmetric diversification of mating pheromones in fission yeast

(2019) Taisuke Seike et al.   PLOS BIOLOGY

MAPK modulation of yeast pheromone signaling output and the role of phosphorylation sites in the scaffold protein Ste5

(2019) Matthew J. Winters et al.   MOLECULAR BIOLOGY OF THE CELL

Engineering a Model Cell for Rational Tuning of GPCR Signaling

(2019) William M. Shaw et al.   CELL

Quantitative analysis of the yeast pheromone pathway

(2019) James P. Shellhammer et al.   YEAST

Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5

(2019) Frank van Drogen et al.   JOURNAL OF CELL BIOLOGY

Role of network-mediated stochasticity in mammalian drug resistance

(2019) Kevin S. Farquhar et al.   Nature Communications

Biosensors design in yeast and applications in metabolic engineering

(2019) Chenxi Qiu et al.   FEMS YEAST RESEARCH

On Information Extraction and Decoding Mechanisms Improved by Noisy Amplification in Signaling Pathways

(2019) Aaron Vazquez-Jimenez et al.   Scientific Reports

Ratiometric GPCR signaling enables directional sensing in yeast

(2019) Nicholas T. Henderson et al.   PLOS BIOLOGY

Drosophila Myoblast Fusion: Invasion and Resistance for the Ultimate Union

(2019) Donghoon M. Lee et al.   Annual Review of Genetics

Connecting central carbon and aromatic amino acid metabolisms to improve de novo 2-phenylethanol production in Saccharomyces cerevisiae

(2019) Else-Jasmijn Hassing et al.   METABOLIC ENGINEERING

Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping

(2019) Jiazhang Lian et al.   Nature Communications

Yeast-based genotoxicity tests for assessing DNA alterations and DNA stress responses: a 40-year overview

(2018) Toshihiko Eki   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Implementing CRISPR-Cas technologies in conventional and non-conventional yeasts: Current state and future prospects

(2018) Hana Raschmanová et al.   BIOTECHNOLOGY ADVANCES

Synthetic biology toolkits and applications in Saccharomyces cerevisiae

(2018) Binbin Chen et al.   BIOTECHNOLOGY ADVANCES

A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate Stabilization

(2018) Maike M.K. Hansen et al.   CELL

New approaches in bioprocess-control: Consortium guidance by synthetic cell-cell communication based on fungal pheromones

(2018) Stefan Hennig et al.   ENGINEERING IN LIFE SCIENCES

Ciguatoxins activate the Calcineurin signalling pathway in Yeasts: Potential for development of an alternative detection tool?

(2018) Hélène Martin-Yken et al.   ENVIRONMENTAL RESEARCH

CDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5

(2018) María Victoria Repetto et al.   MOLECULAR CELL

Timing of gene expression in a cell‐fate decision system

(2018) Delphine Aymoz et al.   Molecular Systems Biology

Negative Feedback Phosphorylation of Gγ Subunit Ste18 and the Ste5 Scaffold Synergistically Regulates MAPK Activation in Yeast

(2018) Shilpa Choudhury et al.   Cell Reports

Creating a functional single-chromosome yeast

(2018) Yangyang Shao et al.   NATURE

A Microfluidic Fluorescent Flow Cytometry Capable of Quantifying Cell Sizes and Numbers of Specific Cytosolic Proteins

(2018) Xiufeng Li et al.   Scientific Reports

Fitness effects of altering gene expression noise in Saccharomyces cerevisiae

(2018) Fabien Duveau et al.   eLife

Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control

(2018) Patrick Harrigan et al.   CELL

Modeling population dynamics in a microbial consortium under control of a synthetic pheromone-mediated communication system

(2018) Andreas Hoffmann et al.   ENGINEERING IN LIFE SCIENCES

Engineering yeast endosymbionts as a step toward the evolution of mitochondria

(2018) Angad P. Mehta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A System for Gene Expression Noise Control in Yeast

(2018) Max Mundt et al.   ACS Synthetic Biology

Droplet microfluidics for synthetic biology

(2017) Philip C. Gach et al.   LAB ON A CHIP

Digital logic circuits in yeast with CRISPR-dCas9 NOR gates

(2017) Miles W. Gander et al.   Nature Communications

Combinatorial metabolic engineering using an orthogonal tri-functional CRISPR system

(2017) Jiazhang Lian et al.   Nature Communications

A modular yeast biosensor for low-cost point-of-care pathogen detection

(2017) Nili Ostrov et al.   Science Advances

Development and evaluation of yeast-based GFP and luciferase reporter assays for chemical-induced genotoxicity and oxidative damage

(2016) Hajime Suzuki et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness

(2016) Leeat Keren et al.   CELL

Strategies to regulate transcription factor–mediated gene positioning and interchromosomal clustering at the nuclear periphery

(2016) Carlo Randise-Hinchliff et al.   JOURNAL OF CELL BIOLOGY

Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture

(2016) Burak Dura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Need for Integrated Approaches in Metabolic Engineering

(2016) Anna Lechner et al.   Cold Spring Harbor Perspectives in Biology

Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease

(2016) Youngbin Lim et al.   Nature Communications

Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast

(2016) Andrés Aranda-Díaz et al.   ACS Synthetic Biology

New biosensor for detection of copper ions in water based on immobilized genetically modified yeast cells

(2015) Irena Vopálenská et al.   BIOSENSORS & BIOELECTRONICS

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Detection of marine microalgal biotoxins using bioassays based on functional expression of tunicate xenobiotic receptors in yeast

(2015) Ingrid Richter et al.   TOXICON

The development and characterization of synthetic minimal yeast promoters

(2015) Heidi Redden et al.   Nature Communications

Controlling Central Carbon Metabolism for Improved Pathway Yields in Saccharomyces cerevisiae

(2015) Sue Zanne Tan et al.   ACS Synthetic Biology

GPCR-Based Chemical Biosensors for Medium-Chain Fatty Acids

(2015) Kuntal Mukherjee et al.   ACS Synthetic Biology

Metabolic engineering of yeast to produce fatty acid-derived biofuels: bottlenecks and solutions

(2015) Jiayuan Sheng et al.   Frontiers in Microbiology

Promoter engineering: Recent advances in controlling transcription at the most fundamental level

(2012) John Blazeck et al.   Biotechnology Journal

Engineered Quorum Sensing Using Pheromone-Mediated Cell-to-Cell Communication in Saccharomyces cerevisiae

(2012) Thomas C. Williams et al.   ACS Synthetic Biology

How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches

(2012) Franziska Witzel et al.   Frontiers in Physiology

Application of the yeast pheromone system for controlled cell-cell communication and signal amplification

(2011) A. Groß et al.   LETTERS IN APPLIED MICROBIOLOGY

Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

(2011) M. C. Good et al.   SCIENCE

Engineering Static and Dynamic Control of Synthetic Pathways

(2010) William J. Holtz et al.   CELL

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

(2010) D. G. Gibson et al.   SCIENCE

Microfluidic control of cell pairing and fusion

(2009) Alison M Skelley et al.   NATURE METHODS

Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics

(2008) C. J. Bashor et al.   SCIENCE

Distinct Roles for Two Gα–Gβ Interfaces in Cell Polarity Control by a Yeast Heterotrimeric G Protein

(2007) Shelly C. Strickfaden et al.   MOLECULAR BIOLOGY OF THE CELL