Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

(2011) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The C-Terminal Tail of Yersinia pseudotuberculosis YopM Is Critical for Interacting with RSK1 and for Virulence

(2010) M. W. McCoy et al.   INFECTION AND IMMUNITY

The assembly of a GTPase–kinase signalling complex by a bacterial catalytic scaffold

(2010) Andrey S. Selyunin et al.   NATURE

The scaffold protein Ste5 directly controls a switch-like mating decision in yeast

(2010) Mohan K. Malleshaiah et al.   NATURE

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-Cell Analysis Reveals That Insulation Maintains Signaling Specificity Between Two Yeast MAPK Pathways with Common Components

(2010) J. C. Patterson et al.   Science Signaling

The Ste5 Scaffold Directs Mating Signaling by Catalytically Unlocking the Fus3 MAP Kinase for Activation

(2009) Matthew Good et al.   CELL

Quantitative effect of scaffold abundance on signal propagation

(2009) Stephen A Chapman et al.   Molecular Systems Biology

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Synthetic metabolic pipelines

(2009) Matthew P DeLisa et al.   NATURE BIOTECHNOLOGY

Synthetic protein scaffolds provide modular control over metabolic flux

(2009) John E Dueber et al.   NATURE BIOTECHNOLOGY

BioNumbers—the database of key numbers in molecular and cell biology

(2009) Ron Milo et al.   NUCLEIC ACIDS RESEARCH

Signaling dynamics of the KSR1 scaffold complex

(2009) M. M. McKay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

(2009) J. D. Scott et al.   SCIENCE

Symmetry-Breaking Polarization Driven by a Cdc42p GEF-PAK Complex

(2008) Lukasz Kozubowski et al.   CURRENT BIOLOGY

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells

(2008) S. An et al.   SCIENCE

Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics

(2008) C. J. Bashor et al.   SCIENCE