Planar cell polarity (PCP) proteins support spermatogenesis through cytoskeletal organization in the testis

Genetic landscape of external auditory canal squamous cell carcinoma

(2020) Kuniaki Sato et al.   CANCER SCIENCE

PRICKLE3 linked to ATPase biogenesis manifested Leber’s hereditary optic neuropathy

(2020) Jialing Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway

(2020) Lingling Liu et al.   Journal of Genetics and Genomics

Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins

(2020) Carl Harrison et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Wnt/β-catenin Signaling in Tissue Self-Organization

(2020) Kelvin W. Pond et al.   Genes

Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer

(2020) Jia Bian et al.   Cells

Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development

(2020) Emily J. Lodge et al.   JCI Insight

A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia

(2019) Ceren Saygı et al.   BMC Medical Genetics

Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation

(2019) Teresa T. Bonello et al.   JOURNAL OF CELL BIOLOGY

Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity

(2019) Mireille Montcouquiol et al.   Cold Spring Harbor Perspectives in Medicine

Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly

(2019) Najim Lahrouchi et al.   Nature Communications

Planar cell polarity protein Dishevelled 3 (Dvl3) regulates ectoplasmic specialization (ES) dynamics in the testis through changes in cytoskeletal organization

(2019) Linxi Li et al.   Cell Death & Disease

Four‐jointed knock‐out delays renal failure in an ADPKD model with kidney injury

(2019) Chiara Formica et al.   JOURNAL OF PATHOLOGY

A very rare form of autosomal dominant progressive myoclonus epilepsy caused by a novel variant in the PRICKLE1 gene

(2019) Hussein Algahtani et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Fat cadherins in mouse models of degenerative ataxias

(2019) Olga Baron et al.   Scientific Reports

Tissue polarity and PCP protein function: C. elegans as an emerging model

(2019) Janine Cravo et al.   CURRENT OPINION IN CELL BIOLOGY

Planar cell polarity signaling in the development of left–right asymmetry

(2019) Jeffrey D. Axelrod   CURRENT OPINION IN CELL BIOLOGY

Nonsense mutations in FZD2 cause autosomal-dominant omodysplasia: Robinow syndrome-like phenotypes

(2018) Keisuke Nagasaki et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Genetics of syndromic and non-syndromic mitral valve prolapse

(2018) Thierry Le Tourneau et al.   HEART

Regulation of spermatid polarity by the actin- and microtubule (MT)-based cytoskeletons

(2018) Linxi Li et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Vangl2 regulates spermatid planar cell polarity through microtubule (MT)-based cytoskeleton in the rat testis

(2018) Haiqi Chen et al.   Cell Death & Disease

Cellular and molecular mechanisms underlying planar cell polarity pathway contributions to cancer malignancy

(2018) Kacey VanderVorst et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

(2018) Sheng Wang et al.   Cell Reports

Wnt–β-catenin signalling in liver development, health and disease

(2018) Maria J. Perugorria et al.   Nature Reviews Gastroenterology & Hepatology

Planar cell polarity in development and disease

(2017) Mitchell T. Butler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Cell polarity and planar cell polarity (PCP) in spermatogenesis

(2017) Haiqi Chen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cell polarity and cytoskeletons—Lesson from the testis

(2017) Qing Wen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions

(2017) Eric Bailly et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Deleterious variants in DCHS1 are prevalent in sporadic cases of mitral valve prolapse

(2017) Alisson Clemenceau et al.   Molecular Genetics & Genomic Medicine

DVL3 Alleles Resulting in a −1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome

(2016) Janson J. White et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors

(2016) Dora Fabijanovic et al.   APMIS

Isolated recessive nail dysplasia caused byFZD6mutations: report of three families and review of the literature

(2016) C. Kasparis et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Planar Cell Polarity (PCP) Protein Vangl2 Regulates Ectoplasmic Specialization Dynamics via Its Effects on Actin Microfilaments in the Testes of Male Rats

(2016) Haiqi Chen et al.   ENDOCRINOLOGY

Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease

(2016) Lin Su et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma

(2016) Chunqiao Liu et al.   HUMAN MOLECULAR GENETICS

Planar cell polarity (PCP) proteins and spermatogenesis

(2016) Haiqi Chen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis

(2016) Elizabeth I. Tang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A novel mutation of the FAT2 gene in spinal meningioma

(2016) Genshu Tate et al.   Oncology Letters

FAT1 mutations cause a glomerulotubular nephropathy

(2016) Heon Yung Gee et al.   Nature Communications

Prickle1mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects

(2016) Brian C. Gibbs et al.   Biology Open

Mutations in DVL1 Cause an Osteosclerotic Form of Robinow Syndrome

(2015) Kieran J. Bunn et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DVL1 Frameshift Mutations Clustering in the Penultimate Exon Cause Autosomal-Dominant Robinow Syndrome

(2015) Janson White et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt)

(2015) Yingzi Yang et al.   Annual Review of Cell and Developmental Biology

Polarized trafficking provides spatial cues for planar cell polarization within a tissue

(2015) Milos Galic et al.   BIOESSAYS

A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia

(2015) H. M. Saal et al.   HUMAN MOLECULAR GENETICS

Identification of Variants in the 4q35 GeneFAT1in Patients with a Facioscapulohumeral Dystrophy-Like Phenotype

(2015) Francesca Puppo et al.   HUMAN MUTATION

Mutations in DCHS1 cause mitral valve prolapse

(2015) Ronen Durst et al.   NATURE

Switching off WNT with precision

(2015) Kim Baumann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exome sequencing reveals a high genetic heterogeneity on familial Hirschsprung disease

(2015) Berta Luzón-Toro et al.   Scientific Reports

Cellular interpretation of the long-range gradient of Four-jointed activity in the Drosophila wing

(2015) Rosalind Hale et al.   eLife

Independent Mutations at Arg181 and Arg274 of Vangl Proteins That Are Associated with Neural Tube Defects in Humans Decrease Protein Stability and Impair Membrane Targeting

(2014) Alexandra Iliescu et al.   BIOCHEMISTRY

Expanding the mutational spectrum associated to neural tube defects: Literature revision and description of novelVANGL1mutations

(2014) E. Merello et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Wnt–Notch signalling crosstalk in development and disease

(2014) Giovanna M. Collu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of Neuronal Migration by Dchs1-Fat4 Planar Cell Polarity

(2014) Sana Zakaria et al.   CURRENT BIOLOGY

Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome

(2014) Mariëlle Alders et al.   HUMAN GENETICS

The cell biology of planar cell polarity

(2014) Danelle Devenport   JOURNAL OF CELL BIOLOGY

The tubulin code: Molecular components, readout mechanisms, and functions

(2014) Carsten Janke   JOURNAL OF CELL BIOLOGY

Deficiency of the Planar Cell Polarity Protein Vangl2 in Podocytes Affects Glomerular Morphogenesis and Increases Susceptibility to Injury

(2014) B. L. Rocque et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genomic and molecular characterization of esophageal squamous cell carcinoma

(2014) De-Chen Lin et al.   NATURE GENETICS

Frameshift Mutations of Cadherin Genes DCHS2, CDH10 and CDH24 Genes in Gastric and Colorectal Cancers with High Microsatellite Instability

(2014) Chang Hyeok An et al.   PATHOLOGY & ONCOLOGY RESEARCH

The Wnt Serpentine Receptor Frizzled-9 Regulates New Bone Formation in Fracture Healing

(2014) Aline Heilmann et al.   PLoS One

Identification of Novel CELSR1 Mutations in Spina Bifida

(2014) Yunping Lei et al.   PLoS One

FAT1 expression and mutations in adult acute lymphoblastic leukemia

(2014) M Neumann et al.   Blood Cancer Journal

Vangl2 Regulates E-Cadherin in Epithelial Cells

(2014) Tadahiro Nagaoka et al.   Scientific Reports

The Wnt/Planar Cell Polarity Pathway Component Vangl2 Induces Synapse Formation through Direct Control of N-Cadherin

(2014) Tadahiro Nagaoka et al.   Cell Reports

The Drosophila Selectin Furrowed Mediates Intercellular Planar Cell Polarity Interactions via Frizzled Stabilization

(2013) Mei-Ling Chin et al.   DEVELOPMENTAL CELL

Regulation of PCP by the Fat signaling pathway

(2013) M. Matis et al.   GENES & DEVELOPMENT

Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

(2013) Joachim Albers et al.   JOURNAL OF CELL BIOLOGY

Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

(2013) Silvia Cappello et al.   NATURE GENETICS

Role of the planar cell polarity gene CELSR1 in neural tube defects and caudal agenesis

(2012) Redouane Allache et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Propagation of Dachsous-Fat Planar Cell Polarity

(2012) Abhijit A. Ambegaonkar et al.   CURRENT BIOLOGY

Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes

(2012) H. Yu et al.   DEVELOPMENT

Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis

(2012) Hirotaka Tao et al.   DEVELOPMENTAL BIOLOGY

The Scribble/Lgl/Dlg Polarity Protein Complex Is a Regulator of Blood-Testis Barrier Dynamics and Spermatid Polarity during Spermatogenesis

(2012) Wenhui Su et al.   ENDOCRINOLOGY

Secreted Frizzled-related protein 1 (sFRP1) regulates spermatid adhesion in the testis via dephosphorylation of focal adhesion kinase and the nectin-3 adhesion protein complex

(2012) Elissa W. P. Wong et al.   FASEB JOURNAL

Comparison of Phenotypes between Different vangl2 Mutants Demonstrates Dominant Effects of the Looptail Mutation during Hair Cell Development

(2012) Haifeng Yin et al.   PLoS One

Mechanical Control of Morphogenesis by Fat/Dachsous/Four-Jointed Planar Cell Polarity Pathway

(2012) F. Bosveld et al.   SCIENCE

Planar cell polarity genes, Celsr1-3, in neural development

(2012) Jia Feng et al.   Neuroscience Bulletin

Mutations in Prickle Orthologs Cause Seizures in Flies, Mice, and Humans

(2011) Hirotaka Tao et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Principles of planar polarity in animal development

(2011) L. V. Goodrich et al.   DEVELOPMENT

Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development

(2011) Y. Mao et al.   DEVELOPMENT

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

(2011) Ryan S. Gray et al.   DEVELOPMENTAL CELL

FZD6is a novel gene for human neural tube defects

(2011) Patrizia De Marco et al.   HUMAN MUTATION

Control of bone formation by the serpentine receptor Frizzled-9

(2011) Joachim Albers et al.   JOURNAL OF CELL BIOLOGY

Planar cell polarity in Drosophila

(2011) Saw Myat Thanda W. Maung et al.   Organogenesis

Contribution of VANGL2 mutations to isolated neural tube defects

(2010) Z Kibar et al.   CLINICAL GENETICS

Four-Jointed Modulates Growth and Planar Polarity by Reducing the Affinity of Dachsous for Fat

(2010) Amy L. Brittle et al.   CURRENT BIOLOGY

Modulation of Fat:Dachsous Binding by the Cadherin Domain Kinase Four-Jointed

(2010) Michael A. Simon et al.   CURRENT BIOLOGY

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

(2010) H. Yu et al.   DEVELOPMENT

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation

(2010) Laura L. Yates et al.   HUMAN MOLECULAR GENETICS

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

(2010) Laura L. Yates et al.   HUMAN MOLECULAR GENETICS

Vang-like protein 2 and Rac1 interact to regulate adherens junctions

(2010) M. Lindqvist et al.   JOURNAL OF CELL SCIENCE

Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning

(2010) Hai Song et al.   NATURE

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus

(2010) Fadel Tissir et al.   NATURE NEUROSCIENCE

A homozygous mutation in INVS causing juvenile nephronophthisis with abnormal reactivity of the Wnt/beta-catenin pathway

(2010) Salvatore Bellavia et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

VANGL2Mutations in Human Cranial Neural-Tube Defects

(2010) Yun-Ping Lei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Williams–Beuren Syndrome

(2010) Barbara R. Pober   NEW ENGLAND JOURNAL OF MEDICINE

Role of the Atypical Cadherin Celsr3 during Development of the Internal Capsule

(2009) L. Zhou et al.   CEREBRAL CORTEX

Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: Background to spermatogenesis, spermatogonia, and spermatocytes

(2009) Louis Hermo et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity

(2009) H. Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Planar Cell Polarity Signaling: The Developing Cell's Compass

(2009) E. K. Vladar et al.   Cold Spring Harbor Perspectives in Biology

A Homozygous Mutation in Human PRICKLE1 Causes an Autosomal-Recessive Progressive Myoclonus Epilepsy-Ataxia Syndrome

(2008) Alexander G. Bassuk et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The genomic basis of the Williams – Beuren syndrome

(2008) C. Schubert   CELLULAR AND MOLECULAR LIFE SCIENCES

Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles

(2008) Danelle Devenport et al.   NATURE CELL BIOLOGY

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

(2008) Sakura Saburi et al.   NATURE GENETICS

Genetic interaction between members of the Vangl family causes neural tube defects in mice

(2008) E. Torban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Four-jointed Is a Golgi Kinase That Phosphorylates a Subset of Cadherin Domains

(2008) H. O. Ishikawa et al.   SCIENCE

Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development

(2008) S. Leah Etheridge et al.   PLoS Genetics