Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

(2021) Botai Li et al.   Nature Communications

The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis

(2021) Mohammad Burhan Uddin et al.   Molecular Cancer

IGF2BP1, a Conserved Regulator of RNA Turnover in Cancer

(2021) Markus Glaß et al.   Frontiers in Molecular Biosciences

Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein

(2020) Marie-Eve Beaulieu et al.   Cells

ERK signalling: a master regulator of cell behaviour, life and fate

(2020) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer

(2020) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

Inhibition of RNA-binding proteins with small molecules

(2020) Peng Wu   Nature Reviews Chemistry

CD44 as a tumor biomarker and therapeutic target

(2020) Hanxiao Xu et al.   Experimental Hematology & Oncology

VICKZ1 enhances tumor progression and metastasis in lung adenocarcinomas in mice

(2019) Yifat Bar-Zakay Rosenfeld et al.   ONCOGENE

IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties

(2019) Robert Dagil et al.   NUCLEIC ACIDS RESEARCH

Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis

(2019) Archita Ghoshal et al.   ONCOGENE

DALI and the persistence of protein shape

(2019) Liisa Holm   PROTEIN SCIENCE

IMP2 and IMP3 cooperate to promote the metastasis of triple-negative breast cancer through destabilization of progesterone receptor

(2018) Hye-Youn Kim et al.   CANCER LETTERS

Targeting insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in metastatic melanoma to increase efficacy of BRAFV600E inhibitors

(2018) TaeWon Kim et al.   MOLECULAR CARCINOGENESIS

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors

(2018) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

Characterizing the interaction between insulin-like growth factor 2 mRNA-binding protein 1 (IMP1) and KRAS expression

(2018) Sebastian Mackedenski et al.   BIOCHEMICAL JOURNAL

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors

(2018) Panagiotis Karras et al.   CANCER CELL

IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner

(2018) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1–3 family

(2017) Courtney K. JnBaptiste et al.   GENES & DEVELOPMENT

A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation

(2017) Lily Mahapatra et al.   Translational Oncology

Mechanism of β-actin mRNA Recognition by ZBP1

(2017) Giuseppe Nicastro et al.   Cell Reports

Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells

(2017) Gunhild Sommer et al.   PLoS One

IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

(2016) Nils Degrauwe et al.   GENES & DEVELOPMENT

KH–RNA interactions: back in the groove

(2015) Giuseppe Nicastro et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Localization of cofilin mRNA to the leading edge of migrating cells promotes directed cell migration

(2015) Y. Maizels et al.   JOURNAL OF CELL SCIENCE

Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis

(2015) Yun-Neng Tang et al.   Nature Communications

A split luciferase-based reporter for detection of a cellular macromolecular complex

(2014) Hiroshi Maita et al.   ANALYTICAL BIOCHEMISTRY

IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1

(2014) M D Faye et al.   ONCOGENE

IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts

(2013) Kathryn E. Hamilton et al.   CARCINOGENESIS

Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1)

(2013) Monika Hämmerle et al.   HEPATOLOGY

Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells

(2013) Chia-Lin Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

(2012) Jessica L. Bell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control

(2012) V. L. Patel et al.   GENES & DEVELOPMENT

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

(2012) Susanne A.I. Seidel et al.   METHODS

IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2

(2011) P. S. Mongroo et al.   CANCER RESEARCH

Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1

(2011) Benjamin Boyerinas et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents

(2011) Evisabel A. Craig et al.   Pigment Cell & Melanoma Research

ZBP1 recognition of  -actin zipcode induces RNA looping

(2010) J. A. Chao et al.   GENES & DEVELOPMENT

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

A role for VICKZ proteins in the progression of colorectal carcinomas: regulating lamellipodia formation

(2008) G Vainer et al.   JOURNAL OF PATHOLOGY