IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors

Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets

(2018) Yahui Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1–3 family

(2017) Courtney K. JnBaptiste et al.   GENES & DEVELOPMENT

A regulatory BMI1/let-7i/ERK3 pathway controls the motility of head and neck cancer cells

(2017) Lobna Elkhadragy et al.   Molecular Oncology

IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1

(2017) Ning Dai et al.   eLife

The LIN28/let-7 Pathway in Cancer

(2017) Julien Balzeau et al.   Frontiers in Genetics

miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients

(2016) András Lánczky et al.   BREAST CANCER RESEARCH AND TREATMENT

UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis

(2016) Laurence Wurth et al.   CANCER CELL

IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

(2016) Nils Degrauwe et al.   GENES & DEVELOPMENT

Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma

(2016) John T. Powers et al.   NATURE

Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)

(2016) Eric L Van Nostrand et al.   NATURE METHODS

The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family

(2016) Bianca Busch et al.   NUCLEIC ACIDS RESEARCH

The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing

(2016) Nils Degrauwe et al.   Cell Reports

IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC

(2016) Hanane Ennajdaoui et al.   Cell Reports

Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival

(2016) Anne E. Conway et al.   Cell Reports

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

The Y3** ncRNA promotes the 3′ end processing of histone mRNAs

(2015) Marcel Köhn et al.   GENES & DEVELOPMENT

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma

(2014) Tony Gutschner et al.   HEPATOLOGY

VICKZ2 protein expression in ovarian serous carcinoma effusions is associated with poor survival

(2014) Ben Davidson et al.   HUMAN PATHOLOGY

Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification)

(2014) Juliane Braun et al.   NUCLEIC ACIDS RESEARCH

The multiMiR R package and database: integration of microRNA–target interactions along with their disease and drug associations

(2014) Yuanbin Ru et al.   NUCLEIC ACIDS RESEARCH

Ensembl 2015

(2014) Fiona Cunningham et al.   NUCLEIC ACIDS RESEARCH

The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer

(2014) Marcell Lederer et al.   SEMINARS IN CANCER BIOLOGY

MicroRNAs in cancer: biomarkers, functions and therapy

(2014) Josie Hayes et al.   TRENDS IN MOLECULAR MEDICINE

IMP3 RNP Safe Houses Prevent miRNA-Directed HMGA2 mRNA Decay in Cancer and Development

(2014) Lars Jønson et al.   Cell Reports

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains

(2013) Kristin Wächter et al.   BIOLOGICAL CHEMISTRY

IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts

(2013) Kathryn E. Hamilton et al.   CARCINOGENESIS

Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1)

(2013) Monika Hämmerle et al.   HEPATOLOGY

IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG)

(2013) Anne Zirkel et al.   NUCLEIC ACIDS RESEARCH

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Evaluating cell lines as tumour models by comparison of genomic profiles

(2013) Silvia Domcke et al.   Nature Communications

A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties

(2013) Jinsuke Nishino et al.   eLife

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

(2012) Jessica L. Bell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling

(2012) N. Stohr et al.   GENES & DEVELOPMENT

Involvement of the mRNA binding protein CRD-BP in the regulation of metastatic melanoma cell proliferation and invasion by hypoxia

(2012) E. A. Craig et al.   JOURNAL OF CELL SCIENCE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines

(2012) Rebecca L. Skalsky et al.   PLoS Pathogens

IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2

(2011) P. S. Mongroo et al.   CANCER RESEARCH

Viral MicroRNA Targetome of KSHV-Infected Primary Effusion Lymphoma Cell Lines

(2011) Eva Gottwein et al.   Cell Host & Microbe

miR-22 represses cancer progression by inducing cellular senescence

(2011) Dan Xu et al.   JOURNAL OF CELL BIOLOGY

A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins

(2011) Shivendra Kishore et al.   NATURE METHODS

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

MicroRNAs in ovarian cancer biology and therapy resistance

(2010) Marijn T.M. van Jaarsveld et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

IGF2BP3 (IMP3) expression is a marker of unfavorable prognosis in ovarian carcinoma of clear cell subtype

(2009) Martin Köbel et al.   MODERN PATHOLOGY

CRD-BP Protects the Coding Region of βTrCP1 mRNA from miR-183-Mediated Degradation

(2009) Irina Elcheva et al.   MOLECULAR CELL

Identification of Let-7-Regulated Oncofetal Genes

(2008) B. Boyerinas et al.   CANCER RESEARCH

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Overexpression of mRNA-binding protein CRD-BP in malignant melanomas

(2008) I Elcheva et al.   ONCOGENE