Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein

MYC, MYCL, and MYCN as therapeutic targets in lung cancer

(2020) Daniel Massó-Vallés et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Target gene-independent functions of MYC oncoproteins

(2020) Apoorva Baluapuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy

(2019) Marie-Eve Beaulieu et al.   Science Translational Medicine

Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA

(2019) Susan Sammak et al.   BIOCHEMISTRY

Max deletion destabilizes MYC protein and abrogates Eµ-Myc lymphomagenesis

(2019) Haritha Mathsyaraja et al.   GENES & DEVELOPMENT

Omomyc reveals new mechanisms to inhibit the MYC oncogene

(2019) Mark J. Demma et al.   MOLECULAR AND CELLULAR BIOLOGY

Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

(2019) Huiying Han et al.   CANCER CELL

Multiple direct interactions of TBP with the MYC oncoprotein

(2019) Yong Wei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mapping Hidden Residual Structure within the Myc bHLH-LZ Domain Using Chemical Denaturant Titration

(2019) Stanislava Panova et al.   STRUCTURE

Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4

(2019) Manuel Iglesias-Bexiga et al.   Scientific Reports

Formation of a structurally-stable conformation by the intrinsically disordered MYC:TRRAP complex

(2019) Edmond J. Feris et al.   PLoS One

Myc phosphorylation in its basic helix–loop–helix region destabilizes transient α-helical structures, disrupting Max and DNA binding

(2018) Pavel Macek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

(2018) Franz X. Schaub et al.   Cell Systems

The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex

(2018) Susan Sammak et al.   FEBS Journal

Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II

(2018) Huasong Lu et al.   NATURE

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

SUMO protease SENP1 deSUMOylates and stabilizes c-Myc

(2018) Xiao-Xin Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide

(2017) Gabriella T. Heller et al.   JOURNAL OF MOLECULAR BIOLOGY

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation

(2017) Kyong-Rim Kieffer-Kwon et al.   MOLECULAR CELL

Sequence-specific DNA binding by MYC/MAX to low-affinity non-E-box motifs

(2017) Michael Allevato et al.   PLoS One

Intrinsically Disordered Proteome of Human Membrane-Less Organelles

(2017) April L. Darling et al.   PROTEOMICS

Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body

(2017) Robert J. Duronio et al.   RNA Biology

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Single-cell pH imaging and detection for pH profiling and label-free rapid identification of cancer-cells

(2017) Hui Hou et al.   Scientific Reports

Phase separation in biology; functional organization of a higher order

(2016) Diana M. Mitrea et al.   Cell Communication and Signaling

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

(2016) Mark W. Richards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different promoter affinities account for specificity in MYC-dependent gene regulation

(2016) Francesca Lorenzin et al.   eLife

Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc

(2016) Chen Yu et al.   Scientific Reports

Myc and its interactors take shape

(2015) William B. Tu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Small-molecule inhibitors of the Myc oncoprotein

(2015) Steven Fletcher et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4

(2015) Román González-Prieto et al.   CELL CYCLE

Perturbation of the c-Myc–Max Protein–Protein Interaction via Synthetic α-Helix Mimetics

(2015) Kwan-Young Jung et al.   JOURNAL OF MEDICINAL CHEMISTRY

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

(2015) Dharmendra Dingar et al.   Journal of Proteomics

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

(2015) Lance R. Thomas et al.   MOLECULAR CELL

Applying thermodynamic profiling in lead finding and optimization

(2015) Gerhard Klebe   NATURE REVIEWS DRUG DISCOVERY

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif

(2015) L R Thomas et al.   ONCOGENE

RNA transcription modulates phase transition-driven nuclear body assembly

(2015) Joel Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity

(2015) Sara Helander et al.   STRUCTURE

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

(2014) Arianna Sabò et al.   NATURE

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

(2014) Susanne Walz et al.   NATURE

Inhibitor of MYC identified in a Krohnke pyridine library

(2014) J. R. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC Activation Is a Hallmark of Cancer Initiation and Maintenance

(2014) M. Gabay et al.   Cold Spring Harbor Perspectives in Medicine

An Overview of MYC and Its Interactome

(2014) M. Conacci-Sorrell et al.   Cold Spring Harbor Perspectives in Medicine

MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

(2013) A. R. Wasylishen et al.   CANCER RESEARCH

Partition of Myc into Immobile vs. Mobile Complexes within Nuclei

(2013) Tilman Rosales et al.   Scientific Reports

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

New structural determinants for c-Myc specific heterodimerization with Max and development of a novel homodimeric c-Myc b-HLH-LZ,

(2012) Marie-Eve Beaulieu et al.   JOURNAL OF MOLECULAR RECOGNITION

The Impact of Small Molecule Binding on the Energy Landscape of the Intrinsically Disordered Protein C-Myc

(2012) Julien Michel et al.   PLoS One

c-MYC Suppresses BIN1 to Release Poly(ADP-Ribose) Polymerase 1: A Mechanism by Which Cancer Cells Acquire Cisplatin Resistance

(2011) S. Pyndiah et al.   Science Signaling

Kinetic Analysis of the Interaction of b/HLH/Z Transcription Factors Myc, Max, and Mad with Cognate DNA

(2010) Ozgur Ecevit et al.   BIOCHEMISTRY

Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation

(2010) Maralice Conacci-Sorrell et al.   CELL

Intrinsically disordered proteins are potential drug targets

(2010) Steven J Metallo   CURRENT OPINION IN CHEMICAL BIOLOGY

Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks

(2009) Rachel H Rose et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery of Novel Myc−Max Heterodimer Disruptors with a Three-Dimensional Pharmacophore Model

(2009) Gabriela Mustata et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Max homodimeric b-HLH-LZ significantly interferes with the specific heterodimerization between the c-Myc and Max b-HLH-LZ in absence of DNA: a quantitative analysis

(2009) François-Olivier McDuff et al.   JOURNAL OF MOLECULAR RECOGNITION

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

(2009) Dalia I. Hammoudeh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecule perturbation of competing interactions between c-Myc and Max

(2008) Ariele Viacava Follis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Myc-Mediated Transcriptional Repression by Recruitment of Histone Deacetylase

(2008) J. F. Kurland et al.   CANCER RESEARCH

Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

(2008) Ariele Viacava Follis et al.   CHEMISTRY & BIOLOGY

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

TOP-IDP-Scale: A New Amino Acid Scale Measuring Propensity for Intrinsic Disorder

(2008) Andrew Campen et al.   PROTEIN AND PEPTIDE LETTERS

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES