Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda

Interactions with Commensal and Pathogenic Bacteria Induce HIV-1 Latency in Macrophages through Altered Transcription Factor Recruitment to the LTR

(2021) Gregory A. Viglianti et al.   JOURNAL OF VIROLOGY

Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency

(2021) Jennifer M. Zerbato et al.   EBioMedicine

Accurate assembly of minority viral haplotypes from next-generation sequencing through efficient noise reduction

(2021) Sergey Knyazev et al.   NUCLEIC ACIDS RESEARCH

Addressing an HIV cure in LMIC

(2021) Sherazaan D. Ismail et al.   Retrovirology

Sex Differences in Human Immunodeficiency Virus Persistence and Reservoir Size During Aging

(2021) Sara Gianella et al.   CLINICAL INFECTIOUS DISEASES

Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

(2021) Steven G. Deeks et al.   NATURE MEDICINE

Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation

(2021) Kien Nguyen et al.   PLoS Pathogens

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies

(2020) Lillian B. Cohn et al.   Cell Host & Microbe

HIV-1 variants are archived throughout infection and persist in the reservoir

(2020) Kelsie Brooks et al.   PLoS Pathogens

Detection of Inducible Replication-Competent HIV-1 Subtype C Provirus Despite Long-Term Antiretroviral Treatment in Perinatally Infected Adolescents in Botswana

(2020) Catherine K. Koofhethile et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus

(2020) Elias K. Halvas et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytomegalovirus and Epstein-Barr virus viremia are associated with HIV DNA levels in the reservoir of Kenyan infants on antiretroviral therapy

(2020) Jennifer A SLYKER et al.   JOURNAL OF INFECTIOUS DISEASES

Subclinical genital herpes shedding in HIV/HSV-2 co-infected women during antiretroviral therapy (ART) is associated with an increase in HIV tissue reservoirs and potentially promotes HIV evolution.

(2020) Tajanna Stinn et al.   JOURNAL OF VIROLOGY

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

(2020) Mohamed Abdel-Mohsen et al.   NATURE MEDICINE

Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo

(2020) Francesco R. Simonetti et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals

(2019) Fredrick H. Omondi et al.   JOURNAL OF VIROLOGY

Reduction of HIV-1 Reservoir Size and Diversity After 1 Year of cART Among Brazilian Individuals Starting Treatment During Early Stages of Acute Infection

(2019) Thaysse Ferreira Leite et al.   Frontiers in Microbiology

Entry of Polarized Effector Cells into Quiescence Forces HIV Latency

(2019) Curtis Dobrowolski et al.   mBio

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

(2019) Katherine M. Bruner et al.   NATURE

HCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional study

(2019) Maria Rosa López-Huertas et al.   Scientific Reports

Development of C-TILDA: A modified TILDA method for reservoir quantification in long term treated patients infected with subtype C HIV-1

(2019) Alessia Bertoldi et al.   JOURNAL OF VIROLOGICAL METHODS

HIV-1 latent reservoir size and diversity are stable following brief treatment interruption

(2018) D. Brenda Salantes et al.   JOURNAL OF CLINICAL INVESTIGATION

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane

(2018) Zheng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measuring replication competent HIV-1: advances and challenges in defining the latent reservoir

(2018) Zheng Wang et al.   Retrovirology

HIV latency in isolated patient CD4 + T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing

(2018) Steven A. Yukl et al.   Science Translational Medicine

Pulmonary Tuberculosis is Associated with Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Co-Infected Ugandans

(2018) Alex Olson et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir

(2018) Biswajit Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of sensitive ddPCR assays to reliably quantify the proviral DNA reservoir in all common circulating HIV subtypes and recombinant forms

(2018) Kobus J Bosman et al.   Journal of the International AIDS Society

Sex-Based Differences in HIV-1 Reservoir Activity and Residual Immune Activation

(2018) Eileen P Scully et al.   JOURNAL OF INFECTIOUS DISEASES

In-depth validation of total HIV-1 DNA assays for quantification of various HIV-1 subtypes

(2018) Sofie Rutsaert et al.   Scientific Reports

Quantification of the Latent HIV-1 Reservoir Using Ultra Deep Sequencing and Primer ID in a Viral Outgrowth Assay

(2017) Sook-Kyung Lee et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Proliferation of latently infected CD4+T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

(2017) Nina N. Hosmane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART

(2017) Ann Wiegand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

(2017) Kien Nguyen et al.   mBio

Barriers to HIV remission research in low- and middle-income countries

(2017) Theresa Rossouw et al.   Journal of the International AIDS Society

The Molecular Basis for Human Immunodeficiency Virus Latency

(2017) Uri Mbonye et al.   Annual Review of Virology

Mycobacterium tuberculosis reactivates latent HIV-1 in T cells in vitro

(2017) Erica C. Larson et al.   PLoS One

Low-Frequency Drug Resistance in HIV-Infected Ugandans on Antiretroviral Treatment Is Associated with Regimen Failure

(2016) Fred Kyeyune et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults

(2016) Huldrych F. Günthard et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Defective proviruses rapidly accumulate during acute HIV-1 infection

(2016) Katherine M Bruner et al.   NATURE MEDICINE

Clonally expanded CD4+T cells can produce infectious HIV-1 in vivo

(2016) Francesco R. Simonetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of concordance between residual viremia and viral variants driving de novo infection of CD4+ T cells on ART

(2016) Maria C. Puertas et al.   Retrovirology

HIV-1 Reservoirs During Suppressive Therapy

(2016) Kirston Barton et al.   TRENDS IN MICROBIOLOGY

HIV-1 Integration Landscape during Latent and Active Infection

(2015) Lillian B. Cohn et al.   CELL

Long-term Virological Outcomes of First-Line Antiretroviral Therapy for HIV-1 in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis

(2015) T. Sonia Boender et al.   CLINICAL INFECTIOUS DISEASES

Towards an HIV-1 cure: measuring the latent reservoir

(2015) Katherine M. Bruner et al.   TRENDS IN MICROBIOLOGY

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

(2015) Francesco Andrea Procopio et al.   EBioMedicine

Global burden of transmitted HIV drug resistance and HIV-exposure categories

(2014) Quang D. Pham et al.   AIDS

Sensitive Deep-Sequencing-Based HIV-1 Genotyping Assay To Simultaneously Determine Susceptibility to Protease, Reverse Transcriptase, Integrase, and Maturation Inhibitors, as Well as HIV-1 Coreceptor Tropism

(2014) Richard M. Gibson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Deep sequencing: Becoming a critical tool in clinical virology

(2014) Miguel E. Quiñones-Mateu et al.   JOURNAL OF CLINICAL VIROLOGY

PAPNC, a novel method to calculate nucleotide diversity from large scale next generation sequencing data

(2014) Wei Shao et al.   JOURNAL OF VIROLOGICAL METHODS

Cross-Clade Ultrasensitive PCR-Based Assays To Measure HIV Persistence in Large-Cohort Studies

(2014) C. Vandergeeten et al.   JOURNAL OF VIROLOGY

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

COMET: adaptive context-based modeling for ultrafast HIV-1 subtype identification

(2014) Daniel Struck et al.   NUCLEIC ACIDS RESEARCH

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

(2014) F. Maldarelli et al.   SCIENCE

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure

(2014) Uri Mbonye et al.   VIROLOGY

Do HIV-1 non-B subtypes differentially impact resistance mutations and clinical disease progression in treated populations? Evidence from a systematic review

(2014) Madhavi Bhargava et al.   Journal of the International AIDS Society

Molecular basis of human immunodeficiency virus type 1 drug resistance: Overview and recent developments

(2013) Luis Menéndez-Arias   ANTIVIRAL RESEARCH

Interleukin-7 promotes HIV persistence during antiretroviral therapy

(2013) C. Vandergeeten et al.   BLOOD

Emerging strategies to deplete the HIV reservoir

(2013) Nancie M. Archin et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Highly Precise Measurement of HIV DNA by Droplet Digital PCR

(2013) Matthew C. Strain et al.   PLoS One

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

(2013) Jaclyn K Mann et al.   Retrovirology

How to best measure HIV reservoirs?

(2013) Christine Rouzioux et al.   Current Opinion in HIV and AIDS

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies

(2013) Susanne Eriksson et al.   PLoS Pathogens

Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay

(2013) Gregory M. Laird et al.   PLoS Pathogens

Analysis of high-depth sequence data for studying viral diversity: a comparison of next generation sequencing platforms using Segminator II.

(2012) John Archer et al.   BMC BIOINFORMATICS

The role of cytokines in the establishment, persistence and eradication of the HIV reservoir

(2012) Claire Vandergeeten et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Multiple NF-κB Sites in HIV-1 Subtype C Long Terminal Repeat Confer Superior Magnitude of Transcription and Thereby the Enhanced Viral Predominance

(2012) Mahesh Bachu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

(2012) Sharad K. Verma et al.   ACS Medicinal Chemistry Letters

Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4+ T Cells

(2011) J. A. Anderson et al.   JOURNAL OF VIROLOGY

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

(2011) Masoud Vedadi et al.   Nature Chemical Biology

Latency profiles of full length HIV-1 molecular clone variants with a subtype specific promoter

(2011) Renée M van der Sluis et al.   Retrovirology

Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV

(2010) Nicolas Chomont et al.   Current Opinion in HIV and AIDS

The Evolutionary Analysis of Emerging Low Frequency HIV-1 CXCR4 Using Variants through Time—An Ultra-Deep Approach

(2010) John Archer et al.   PLoS Computational Biology

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid

(2009) Nancie M. Archin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

The evolution of HIV treatment guidelines: Current state-of-the-art of ART

(2009) Andrew R. Zolopa   ANTIVIRAL RESEARCH

Clinical management of HIV-1 resistance

(2009) Roger Paredes et al.   ANTIVIRAL RESEARCH

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Cellular Levels of HIV Unspliced RNA from Patients on Combination Antiretroviral Therapy with Undetectable Plasma Viremia Predict the Therapy Outcome

(2009) Alexander O. Pasternak et al.   PLoS One

The Challenge of Finding a Cure for HIV Infection

(2009) D. D. Richman et al.   SCIENCE

Acyclovir Is Activated into a HIV-1 Reverse Transcriptase Inhibitor in Herpesvirus-Infected Human Tissues

(2008) Andrea Lisco et al.   Cell Host & Microbe

Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

(2008) R. Pearson et al.   JOURNAL OF VIROLOGY

The Challenge of HIV-1 Subtype Diversity

(2008) Barbara S. Taylor et al.   NEW ENGLAND JOURNAL OF MEDICINE