How to best measure HIV reservoirs?

Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies

(2013) Susanne Eriksson et al.   PLoS Pathogens

The effect of intensification with raltegravir on the HIV-1 reservoir of latently infected memory CD4 T cells in suppressed patients

(2012) Alejandro Vallejo et al.   AIDS

Integrated HIV DNA accumulates prior to treatment while episomal HIV DNA records ongoing transmission afterwards

(2012) John M. Murray et al.   AIDS

Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials

(2012) Angela M. Mexas et al.   AIDS

Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

(2012) Sophie Bouchat et al.   AIDS

HIV-1 control after transient antiretroviral treatment initiated in primary infection: role of patient characteristics and effect of therapy

(2012) Cécile Goujard et al.   ANTIVIRAL THERAPY

Immunovirologic Control 24 Months After Interruption of Antiretroviral Therapy Initiated Close to HIV Seroconversion

(2012) Sara Lodi et al.   ARCHIVES OF INTERNAL MEDICINE

Immune Responses Driven by Protective Human Leukocyte Antigen Alleles From Long-term Nonprogressors Are Associated With Low HIV Reservoir in Central Memory CD4 T Cells

(2012) Benjamin Descours et al.   CLINICAL INFECTIOUS DISEASES

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication

(2012) Evelyn Eisele et al.   IMMUNITY

Effect of Histone Deacetylase Inhibitors on HIV Production in Latently Infected, Resting CD4+ T Cells From Infected Individuals Receiving Effective Antiretroviral Therapy

(2012) J. Blazkova et al.   JOURNAL OF INFECTIOUS DISEASES

Low-level detection and quantitation of cellular HIV-1 DNA and 2-LTR circles using droplet digital PCR

(2012) Timothy J. Henrich et al.   JOURNAL OF VIROLOGICAL METHODS

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Switching Virally Suppressed, Treatment-Experienced Patients to a Raltegravir-Containing Regimen Does Not Alter Levels of HIV-1 DNA

(2012) Yu Ming Paul Lam et al.   PLoS One

Lymphoid Tissue Damage in HIV-1 Infection Depletes Naïve T Cells and Limits T Cell Reconstitution after Antiretroviral Therapy

(2012) Ming Zeng et al.   PLoS Pathogens

HIV cure and eradication: how will we get from the laboratory to effective clinical trials?

(2011) Sharon R Lewin et al.   AIDS

Impact of HIV Type 1 DNA Levels on Spontaneous Disease Progression: A Meta-Analysis

(2011) Chrissa G. Tsiara et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Relationship Between Residual Plasma Viremia and the Size of HIV Proviral DNA Reservoirs in Infected Individuals Receiving Effective Antiretroviral Therapy

(2011) Tae-Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule

(2011) L. Josefsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages and HIV-1

(2011) Viviana Cobos-Jiménez et al.   Current Opinion in HIV and AIDS

Elite controllers as a model of functional cure

(2011) Brigitte Autran et al.   Current Opinion in HIV and AIDS

Elite Suppressors Harbor Low Levels of Integrated HIV DNA and High Levels of 2-LTR Circular HIV DNA Compared to HIV+ Patients On and Off HAART

(2011) Erin H. Graf et al.   PLoS Pathogens

Episomal Viral cDNAs Identify a Reservoir That Fuels Viral Rebound after Treatment Interruption and That Contributes to Treatment Failure

(2011) Mark Sharkey et al.   PLoS Pathogens

Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy

(2010) Steven A Yukl et al.   AIDS

Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection

(2010) Laurent Hocqueloux et al.   AIDS

Infrequent Recovery of HIV from but Robust Exogenous Infection of Activated CD4+T Cells in HIV Elite Controllers

(2010) B. Julg et al.   CLINICAL INFECTIOUS DISEASES

Despite being highly diverse, immunovirological status strongly correlates with clinical symptoms during primary HIV-1 infection: a cross-sectional study based on 674 patients enrolled in the ANRS CO 06 PRIMO cohort

(2010) J. Ghosn et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A high HIV DNA level in PBMCs at antiretroviral treatment interruption predicts a shorter time to treatment resumption, independently of the CD4 nadir

(2010) Christophe Piketty et al.   JOURNAL OF MEDICAL VIROLOGY

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

(2010) Maria J Buzón et al.   NATURE MEDICINE

Profound Depletion of HIV-1 Transcription in Patients Initiating Antiretroviral Therapy during Acute Infection

(2010) Adrian Schmid et al.   PLoS One

HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals

(2010) D. Trono et al.   SCIENCE

Patients on HAART often have an excess of unintegrated HIV DNA: Implications for monitoring reservoirs

(2010) Luis M. Agosto et al.   VIROLOGY

Introduction: challenges to finding a cure for HIV infection

(2010) Douglas D Richman   Current Opinion in HIV and AIDS

The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-Infected Patients on Antiretroviral Therapy: A Randomized Controlled Trial

(2010) Rajesh T. Gandhi et al.   PLOS MEDICINE

Corneal Stromal Bed Quality Obtained With Mechanical Microkeratome and Femtosecond Laser

(2009) Sathish Srinivasan et al.   CORNEA

Immunologic and Virologic Events in Early HIV Infection Predict Subsequent Rate of Progression

(2009) Anuradha Ganesan et al.   JOURNAL OF INFECTIOUS DISEASES

Viral Sanctuaries during Highly Active Antiretroviral Therapy in a Nonhuman Primate Model for AIDS

(2009) T. W. North et al.   JOURNAL OF VIROLOGY

Detecting HIV-1 integration by repetitive-sampling Alu-gag PCR

(2009) Megan K. Liszewski et al.   METHODS

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

The Challenge of Finding a Cure for HIV Infection

(2009) D. D. Richman et al.   SCIENCE

HIV-1 DNA for the measurement of the HIV reservoir is predictive of disease progression in seroconverters whatever the mode of result expression is

(2008) Véronique Avettand-Fènoël et al.   JOURNAL OF CLINICAL VIROLOGY

LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01)

(2008) Avettand-Fènoël Véronique et al.   JOURNAL OF MEDICAL VIROLOGY

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

(2008) S. Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients

(2008) Jianqing J. Yu et al.   VIROLOGY