Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency

Defective HIV-1 proviruses produce viral proteins

(2020) Hiromi Imamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Impact of Cellular Proliferation on the HIV-1 Reservoir

(2020) Maria C. Virgilio et al.   Viruses-Basel

Diverse effects of interferon alpha on the establishment and reversal of HIV latency

(2020) Renée M. Van der Sluis et al.   PLoS Pathogens

Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents

(2020) Sushama Telwatte et al.   AIDS

Vesatolimod, a toll-like receptor 7 agonist, induces immune activation in virally suppressed adults with HIV-1

(2020) Sharon A Riddler et al.   CLINICAL INFECTIOUS DISEASES

A phase I/II randomized, placebo-controlled trial of romidepsin in persons with HIV-1 on suppressive antiretroviral therapy to assess safety and activation of HIV-1 expression (A5315)

(2020) Deborah K McMahon et al.   JOURNAL OF INFECTIOUS DISEASES

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

(2019) Katherine M. Bruner et al.   NATURE

Effects of 24 Week Toll-Like Receptor 9 Agonist Treatment in HIV-1+ Individuals

(2019) Line K. Vibholm et al.   AIDS

Combination of quadruplex qPCR and next-generation sequencing for qualitative and quantitative analysis of the HIV-1 latent reservoir

(2019) Christian Gaebler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus

(2019) Andrew Musick et al.   Frontiers in Microbiology

Between a shock and a hard place: challenges and developments in HIV latency reversal

(2019) Jennifer M Zerbato et al.   Current Opinion in Virology

Maraviroc Is Associated with Latent HIV-1 Reactivation through NF-κB Activation in Resting CD4+ T Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy

(2018) Nadia Madrid-Elena et al.   JOURNAL OF VIROLOGY

HIV latency in isolated patient CD4 + T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing

(2018) Steven A. Yukl et al.   Science Translational Medicine

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy

(2018) So-Yon Lim et al.   Science Translational Medicine

Barriers and strategies to achieve a cure for HIV

(2018) Matthew C Pitman et al.   Lancet HIV

Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals

(2018) Sara Moron-Lopez et al.   AIDS

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

(2018) Erica N. Borducchi et al.   NATURE

A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation

(2018) Daniel B. Reeves et al.   Nature Communications

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency

(2018) Sushama Telwatte et al.   PLoS Pathogens

Improved assays to measure and characterize the inducible HIV reservoir

(2018) Marta Massanella et al.   EBioMedicine

Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

(2017) Nancie M. Archin et al.   JOURNAL OF CLINICAL INVESTIGATION

Proliferation of latently infected CD4+T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

(2017) Nina N. Hosmane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART

(2017) Ann Wiegand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4 + T Cells from Effectively Treated Participants

(2017) Bonnie Hiener et al.   Cell Reports

Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy

(2016) Carolina Gutiérrez et al.   AIDS

Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+T CellsIn Vitro

(2016) Jennifer M. Zerbato et al.   JOURNAL OF VIROLOGY

Defective proviruses rapidly accumulate during acute HIV-1 infection

(2016) Katherine M Bruner et al.   NATURE MEDICINE

Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy

(2016) Hiromi Imamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial

(2016) Steffen Leth et al.   Lancet HIV

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

(2015) Ole S. Søgaard et al.   PLoS Pathogens

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study

(2015) Julian H Elliott et al.   Lancet HIV

HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat

(2014) N. M. Archin et al.   JOURNAL OF INFECTIOUS DISEASES

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

(2014) Datsen George Wei et al.   PLoS Pathogens

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy

(2013) A. M. Spivak et al.   CLINICAL INFECTIOUS DISEASES

Comparative analysis of triplex nucleic acid test assays in United States blood donors

(2013) Susan L. Stramer et al.   TRANSFUSION

Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression

(2013) J. Karn et al.   Cold Spring Harbor Perspectives in Medicine

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

A new way of measuring apoptosis by absolute quantitation of inter-nucleosomally fragmented genomic DNA

(2012) David J. Hooker et al.   NUCLEIC ACIDS RESEARCH

Efficient transcription through an intron requires the binding of an Sm-type U1 snRNP with intact stem loop II to the splice donor

(2010) Marina R. Alexander et al.   NUCLEIC ACIDS RESEARCH

Corneal Stromal Bed Quality Obtained With Mechanical Microkeratome and Femtosecond Laser

(2009) Sathish Srinivasan et al.   CORNEA

The transcriptional transactivator Tat selectively regulates viral splicing

(2009) Joseph A. Jablonski et al.   NUCLEIC ACIDS RESEARCH