Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

No Evidence for Selection of HIV-1 with Enhanced Gag-Protease or Nef Function among Breakthrough Infections in the CAPRISA 004 Tenofovir Microbicide Trial

(2013) Denis R. Chopera et al.   PLoS One

Attenuation of multiple Nef functions in HIV-1 elite controllers

(2013) Philip Mwimanzi et al.   Retrovirology

Dynamic range of Nef functions in chronic HIV-1 infection

(2013) Philip Mwimanzi et al.   VIROLOGY

Genetic and Functional Analysis of HIV Type 1 nef Gene Derived from Long-Term Nonprogressor Children: Association of Attenuated Variants with Slow Progression to Pediatric AIDS

(2012) Guillermo Corró et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Immune Selection In Vitro Reveals Human Immunodeficiency Virus Type 1 Nef Sequence Motifs Important for Its Immune Evasion Function In Vivo

(2012) M. J. Lewis et al.   JOURNAL OF VIROLOGY

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation

(2012) U. S. Rajapaksa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

(2012) Pieter J Meuwissen et al.   Retrovirology

Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix

(2012) Lillian S Kuo et al.   Retrovirology

Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants?

(2012) Philip Mwimanzi et al.   Viruses-Basel

Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy

(2011) Peter W. Hunt et al.   AIDS

Extended high viremics

(2011) Vladimir Novitsky et al.   AIDS

Mechanisms of HIV-1 Nef Function and Intracellular Signaling

(2011) John L. Foster et al.   Journal of Neuroimmune Pharmacology

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages

(2011) Philip Mwimanzi et al.   Retrovirology

Differential Anti-APOBEC3G Activity of HIV-1 Vif Proteins Derived from Different Subtypes

(2010) Yukie Iwabu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gag-Protease-Mediated Replication Capacity in HIV-1 Subtype C Chronic Infection: Associations with HLA Type and Clinical Parameters

(2010) Jaclyn K. Wright et al.   JOURNAL OF VIROLOGY

Tracking a century of global expansion and evolution of HIV to drive understanding and to combat disease

(2010) Denis M Tebit et al.   LANCET INFECTIOUS DISEASES

Subtype-associated differences in HIV-1 reverse transcription affect the viral replication

(2010) Sergey Iordanskiy et al.   Retrovirology

Impact of HIV-1 viral subtype on disease progression and response to antiretroviral therapy

(2010) Philippa J Easterbrook et al.   Journal of the International AIDS Society

Single Nef Proteins from HIV Type 1 Subtypes C and F Fail to Upregulate Invariant Chain Cell Surface Expression But Are Active for Other Functions

(2009) Gabriela Turk et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

CCR5- and CXCR4-Tropic Subtype C Human Immunodeficiency Virus Type 1 Isolates Have a Lower Level of Pathogenic Fitness than Other Dominant Group M Subtypes: Implications for the Epidemic

(2009) A. Abraha et al.   JOURNAL OF VIROLOGY

Phylogenetic Analysis of Population-Based and Deep Sequencing Data to Identify Coevolving Sites in the nef Gene of HIV-1

(2009) A. F.Y. Poon et al.   MOLECULAR BIOLOGY AND EVOLUTION

HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins

(2009) Zabrina L. Brumme et al.   PLoS One

Genetic Characterization of Human Immunodeficiency Virus Type 1 in Elite Controllers: Lack of Gross Genetic Defects or Common Amino Acid Changes

(2008) T. Miura et al.   JOURNAL OF VIROLOGY

The Challenge of HIV-1 Subtype Diversity

(2008) Barbara S. Taylor et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIV-1 Nef: at the crossroads

(2008) John L Foster et al.   Retrovirology

HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

(2008) Malinda R. Schaefer et al.   PLoS Pathogens