Rethinking agrochemical safety assessment: A perspective

Increasing confidence in waiving dermal toxicity studies: A comparison of oral and dermal acute data with alternative approaches for agrochemicals and products

(2021) Sophie van der Kamp et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment

(2021) Yu-Mei Tan et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Implementing a globally harmonized risk assessment‐based approach for regulatory decision‐making of crop protection products

(2020) Douglas C Wolf et al.   PEST MANAGEMENT SCIENCE

Predicting the Safety of Medicines in Pregnancy: a Workshop Report

(2020) J.M. Clements et al.   REPRODUCTIVE TOXICOLOGY

A novel human pluripotent stem cell-based assay to predict developmental toxicity

(2020) Karin Lauschke et al.   ARCHIVES OF TOXICOLOGY

Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens

(2020) Miriam N. Jacobs et al.   ARCHIVES OF TOXICOLOGY

Use of the kinetically-derived maximum dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management

(2020) Minne B. Heringa et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Regulating human safety: How dose selection in toxicity studies impacts human health hazard assessment and subsequent risk management options

(2020) Marjolijn Woutersen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models—A Perspective

(2020) Dania Movia et al.   Frontiers in Bioengineering and Biotechnology

Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits

(2020) Fiona Sewell et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals

(2020) Mirjam Luijten et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Chemical carcinogenicity revisited 3: Risk assessment of carcinogenic potential based on the current state of knowledge of carcinogenesis in humans

(2019) Samuel M. Cohen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Reducing the need for animal testing while increasing efficiency in a pesticide regulatory setting: Lessons from the EPA Office of Pesticide Programs’ Hazard and Science Policy Council

(2019) Evisabel Craig et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The future trajectory of adverse outcome pathways: a commentary

(2018) Fiona Sewell et al.   ARCHIVES OF TOXICOLOGY

An evaluation of the fixed concentration procedure for assessment of acute inhalation toxicity

(2018) Fiona Sewell et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report

(2018) Amy J. Clippinger et al.   TOXICOLOGY IN VITRO

Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

(2018) Amy J. Clippinger et al.   TOXICOLOGY IN VITRO

Goodbye to the bioassay

(2018) Jay I. Goodman   Toxicology Research

Rethinking developmental toxicity testing: Evolution or revolution?

(2018) Anthony R. Scialli et al.   Birth Defects Research

Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals

(2018) Helen Prior et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A simple problem formulation framework to create the right solution to the right problem

(2018) Alaina Sauve-Ciencewicki et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A defined approach for predicting skin sensitisation hazard and potency based on the guided integration of in silico, in chemico and in vitro data using exclusion criteria

(2018) Donna S. Macmillan et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Biometrical evaluation of the performance of the revised OECD Test Guideline 402 for assessing acute dermal toxicity

(2017) H. Mielke et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Temperature-activated ion channels in neural crest cells confer maternal fever–associated birth defects

(2017) Mary R. Hutson et al.   Science Signaling

Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds

(2017) Peter I. Racz et al.   TOXICOLOGY IN VITRO

Temperature-activated ion channels in neural crest cells confer maternal fever–associated birth defects

(2017) Mary R. Hutson et al.   Science Signaling

An enhanced C. elegans based platform for toxicity assessment

(2017) Huajiang Xiong et al.   Scientific Reports

A Developmental Toxicology Assay Platform for Screening Teratogenic Liability of Pharmaceutical Compounds

(2016) Karen Augustine-Rauch et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties

(2016) Jan Willem van der Laan et al.   CRITICAL REVIEWS IN TOXICOLOGY

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis

(2015) Martyn T. Smith et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Adverse Outcome Pathways can drive non-animal approaches for safety assessment

(2015) Natalie Burden et al.   JOURNAL OF APPLIED TOXICOLOGY

A global initiative to refine acute inhalation studies through the use of ‘evident toxicity’ as an endpoint: Towards adoption of the fixed concentration procedure

(2015) Fiona Sewell et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Advancing the 3Rs in regulatory toxicology – Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union

(2014) Erwin Annys et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Fishing for Teratogens: A Consortium Effort for a Harmonized Zebrafish Developmental Toxicology Assay

(2014) Jonathan S. Ball et al.   TOXICOLOGICAL SCIENCES

Reducing pre-clinical blood volumes for toxicokinetics: toxicologists, pathologists and bioanalysts unite

(2014) Kathryn Chapman et al.   Bioanalysis

Establishment and Assessment of a New Human Embryonic Stem Cell-Based Biomarker Assay for Developmental Toxicity Screening

(2013) Jessica A. Palmer et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Establishment of a Molecular Embryonic Stem Cell Developmental Toxicity Assay

(2012) Julieta M. Panzica-Kelly et al.   TOXICOLOGICAL SCIENCES

Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay – Progress report on phase I

(2011) A.-L. Gustafson et al.   REPRODUCTIVE TOXICOLOGY

An Analysis of Pharmaceutical Experience with Decades of Rat Carcinogenicity Testing

(2011) Frank D. Sistare et al.   TOXICOLOGIC PATHOLOGY

The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides

(2009) Richard Billington et al.   CRITICAL REVIEWS IN TOXICOLOGY