Use of the kinetically-derived maximum dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management

Title
Use of the kinetically-derived maximum dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management
Authors
Keywords
Kinetically derived maximum dose, KMD, Inflection point, Top dose selection, 3Rs, Classification, Hazard and risk assessment
Journal
REGULATORY TOXICOLOGY AND PHARMACOLOGY
Volume 114, Issue -, Pages 104659
Publisher
Elsevier BV
Online
2020-04-22
DOI
10.1016/j.yrtph.2020.104659

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