Establishment and Assessment of a New Human Embryonic Stem Cell-Based Biomarker Assay for Developmental Toxicity Screening

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

(2013) Clay W Scott et al.   TOXICOLOGY LETTERS

Pharmacokinetic profiles of artesunate following multiple intravenous doses of 2, 4, and 8 mg/kg in healthy volunteers: Phase 1b study

(2012) Robert Miller et al.   MALARIA JOURNAL

Development of a Streamlined Rat Whole Embryo Culture Assay for Classifying Teratogenic Potential of Pharmaceutical Compounds

(2012) Cindy Zhang et al.   TOXICOLOGICAL SCIENCES

Not a walk in the park: the ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design

(2011) Jason Thomson et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Innovative approaches in the embryonic stem cell test (EST)

(2011) Peter et al.   Frontiers in Bioscience-Landmark

Physiologic changes in homocysteine metabolism in pregnancy: A longitudinal study in Spain

(2011) Natalia Úbeda et al.   NUTRITION

Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways

(2011) Sudin Bhattacharya et al.   PLoS One

Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds

(2011) Ingrid W.T. Selderslaghs et al.   REPRODUCTIVE TOXICOLOGY

Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay – Progress report on phase I

(2011) A.-L. Gustafson et al.   REPRODUCTIVE TOXICOLOGY

Zebrafish (Danio rerio) embryos as a model for testing proteratogens

(2011) Stefan Weigt et al.   TOXICOLOGY

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics

(2011) N.C. Kleinstreuer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Relative developmental toxicity potencies of retinoids in the embryonic stem cell test compared with their relative potencies in in vivo and two other in vitro assays for developmental toxicity

(2011) Jochem Louisse et al.   TOXICOLOGY LETTERS

A different approach to validating screening assays for developmental toxicity

(2010) George P. Daston et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Development of a zebrafish embryo teratogenicity assay and quantitative prediction model

(2010) Kimberly C. Brannen et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Human stem cells and drug screening: opportunities and challenges

(2010) Allison D. Ebert et al.   NATURE REVIEWS DRUG DISCOVERY

Embryotoxicant-Specific Transcriptomic Responses in Rat Postimplantation Whole-Embryo Culture

(2010) Joshua F. Robinson et al.   TOXICOLOGICAL SCIENCES

Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics

(2010) Paul R. West et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Embryotoxicity of the artemisinin antimalarials and potential consequences for use in women in the first trimester

(2009) Robert L. Clark   REPRODUCTIVE TOXICOLOGY

Protein and Amino Acid Metabolism in the Human Newborn

(2008) Satish C. Kalhan et al.   Annual Review of Nutrition

Assessment of the Embryonic Stem Cell Test and application and use in the pharmaceutical industry

(2008) Jennifer A. Paquette et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Zebrafish: a predictive model for assessing drug-induced toxicity

(2008) Patricia McGrath et al.   DRUG DISCOVERY TODAY