Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19

(2021) Robert L. Gottlieb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

IFN-α2a Therapy in Two Patients with Inborn Errors of TLR3 and IRF3 Infected with SARS-CoV-2

(2021) Romain Lévy et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Shared and Unique Features of Human Interferon-Beta and Interferon-Alpha Subtypes

(2021) Megen C. Wittling et al.   Frontiers in Immunology

Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity

(2021) Daisy A. Hoagland et al.   IMMUNITY

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

(2021) Angela Wahl et al.   NATURE

Dual Nature of Type I Interferons in SARS-CoV-2-Induced Inflammation

(2021) Cecile King et al.   TRENDS IN IMMUNOLOGY

The effect of recombinant human interferon alpha nasal drops to prevent COVID-19 pneumonia for medical staff in an epidemic area

(2021) Zhongji Meng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain

(2021) Jesús Troya et al.   JOURNAL OF CLINICAL IMMUNOLOGY

In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease

(2021) Natalie Heinen et al.   Viruses-Basel

Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

(2021) Philip V’kovski et al.   PLOS BIOLOGY

Assignment of Epidemiological Lineages in an Emerging Pandemic Using the Pangolin Tool

(2021) Áine O’Toole et al.   Virus Evolution

Functional Comparison of IFN‐α Subtypes Reveals Potent HBV Suppression by a Concerted Action of IFN‐α and ‐γ Signaling

(2020) Jieliang Chen et al.   HEPATOLOGY

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Susceptibility of SARS-CoV-2 to UV Irradiation

(2020) Christiane Silke Heilingloh et al.   AMERICAN JOURNAL OF INFECTION CONTROL

Elevated MUC1 and MUC5AC mucin protein levels in airway mucus of critical ill COVID‐19 Patients

(2020) Wenju Lu et al.   JOURNAL OF MEDICAL VIROLOGY

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

(2020) Abigail Vanderheiden et al.   JOURNAL OF VIROLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

(2020) Megan L. Stanifer et al.   Cell Reports

Interplay between SARS-CoV-2 and the type I interferon response

(2020) Margarida Sa Ribero et al.   PLoS Pathogens

LY6E impairs coronavirus fusion and confers immune control of viral disease

(2020) Stephanie Pfaender et al.   Nature Microbiology

Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV.

(2020) Kumari G. Lokugamage et al.   JOURNAL OF VIROLOGY

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

(2020) Lisa Miorin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Two distinct immunopathological profiles in autopsy lungs of COVID-19

(2020) Ronny Nienhold et al.   Nature Communications

Qualitative Differences Between the IFNα subtypes and IFNβ Influence Chronic Mucosal HIV-1 Pathogenesis

(2020) Kejun Guo et al.   PLoS Pathogens

A Novel In-Cell ELISA Assay Allows Rapid and Automated Quantification of SARS-CoV-2 to Analyze Neutralizing Antibodies and Antiviral Compounds

(2020) Lara Schöler et al.   Frontiers in Immunology

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

(2020) Peter Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon-α2b Treatment for COVID-19 Is Associated with Improvements in Lung Abnormalities

(2020) Qiong Zhou et al.   Viruses-Basel

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Phillip D Monk et al.   Lancet Respiratory Medicine

Dose-Dependent Differences in HIV Inhibition by Different Interferon Alpha Subtypes While Having Overall Similar Biologic Effects

(2019) Erika Schlaepfer et al.   mSphere

Shared and Distinct Functions of Type I and Type III Interferons

(2019) Helen M. Lazear et al.   IMMUNITY

Decoding type I and III interferon signalling during viral infection

(2019) Emily V. Mesev et al.   Nature Microbiology

Precision mouse models with expanded tropism for human pathogens

(2019) Angela Wahl et al.   NATURE BIOTECHNOLOGY

Diverse Immunomodulatory Effects of Individual IFNα Subtypes on Virus-Specific CD8+ T Cell Responses

(2019) Julia Dickow et al.   Frontiers in Immunology

When Hepatitis B Virus Meets Interferons

(2018) Guangyun Tan et al.   Frontiers in Microbiology

Deciphering of the Human Interferon-Regulated Proteome by Mass Spectrometry-Based Quantitative Analysis Reveals Extent and Dynamics of Protein Induction and Repression

(2017) Dominik A. Megger et al.   Frontiers in Immunology

Different antiviral effects of IFNα subtypes in a mouse model of HBV infection

(2017) Jingjiao Song et al.   Scientific Reports

Peginterferon lambda for the treatment of HBeAg-positive chronic hepatitis B: A randomized phase 2b study (LIRA-B)

(2016) Henry L.Y. Chan et al.   JOURNAL OF HEPATOLOGY

Interferon Alpha Subtype-Specific Suppression of HIV-1 InfectionIn Vivo

(2016) Kerry J. Lavender et al.   JOURNAL OF VIROLOGY

Coronaviruses and the human airway: a universal system for virus-host interaction studies

(2016) Hulda R. Jonsdottir et al.   Virology Journal

The innate immune function of airway epithelial cells in inflammatory lung disease

(2015) Pieter S. Hiemstra et al.   EUROPEAN RESPIRATORY JOURNAL

Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms

(2015) Michael S. Harper et al.   PLoS Pathogens

Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types

(2014) Elena Tomasello et al.   Frontiers in Immunology

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

CD4+ T Cells Develop Antiretroviral Cytotoxic Activity in the Absence of Regulatory T Cells and CD8+ T Cells

(2013) N. Manzke et al.   JOURNAL OF VIROLOGY

OSA: a fast and accurate alignment tool for RNA-Seq

(2012) Jun Hu et al.   BIOINFORMATICS

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

Interferon-alpha Subtype 11 Activates NK Cells and Enables Control of Retroviral Infection

(2012) Kathrin Gibbert et al.   PLoS Pathogens

Binding and activity of all human alpha interferon subtypes

(2011) Thomas B. Lavoie et al.   CYTOKINE

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

The differential activity of interferon-α subtypes is consistent among distinct target genes and cell types

(2010) Herwig P. Moll et al.   CYTOKINE

Benefits and risks of interferon therapy for hepatitis B

(2010) Robert Perrillo   HEPATOLOGY