Coronaviruses and the human airway: a universal system for virus-host interaction studies

Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract

(2016) David K. Meyerholz et al.   AMERICAN JOURNAL OF PATHOLOGY

Detection of feline coronavirus spike gene mutations as a tool to diagnose feline infectious peritonitis

(2016) Sandra Felten et al.   JOURNAL OF FELINE MEDICINE AND SURGERY

Alveolar Development and Disease

(2015) Jeffrey A. Whitsett et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Human Coronavirus-Associated Influenza-Like Illness in the Community Setting in Peru

(2015) Hugo Razuri et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

(2015) Yahira M. Báez-Santos et al.   ANTIVIRAL RESEARCH

Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells

(2015) C Lauber et al.   GENES AND IMMUNITY

Estimating the risk of Middle East respiratory syndrome (MERS) death during the course of the outbreak in the Republic of Korea, 2015

(2015) Kenji Mizumoto et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Host-directed therapies for improving poor treatment outcomes associated with the middle east respiratory syndrome coronavirus infections

(2015) Alimuddin Zumla et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study

(2015) Sarah Shalhoub et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus

(2015) Zhiqiang Wu et al.   JOURNAL OF INFECTIOUS DISEASES

Evidence for an Ancestral Association of Human Coronavirus 229E with Bats

(2015) Victor Max Corman et al.   JOURNAL OF VIROLOGY

Human Coronavirus HKU1 Spike Protein UsesO-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme

(2015) Xingchuan Huang et al.   JOURNAL OF VIROLOGY

Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein

(2015) Asisa Volz et al.   JOURNAL OF VIROLOGY

Generation of a Transgenic Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

(2015) Anurodh Shankar Agrawal et al.   JOURNAL OF VIROLOGY

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology

(2015) Sarah Gordon   ALTEX-Alternatives to Animal Experimentation

Animal models for SARS and MERS coronaviruses

(2015) Lisa M Gretebeck et al.   Current Opinion in Virology

Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

(2015) Alain Le Coupanec et al.   PLoS Pathogens

Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study

(2014) Jaffar A. Al-Tawfiq et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling

(2014) K. L. Matthews et al.   JOURNAL OF GENERAL VIROLOGY

Enteric disease in postweaned beef calves associated with Bovine coronavirus clade 2

(2014) Robert W. Fulton et al.   JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION

Identification of Diverse Alphacoronaviruses and Genomic Characterization of a Novel Severe Acute Respiratory Syndrome-Like Coronavirus from Bats in China

(2014) B. He et al.   JOURNAL OF VIROLOGY

Rooting the Phylogenetic Tree of Middle East Respiratory Syndrome Coronavirus by Characterization of a Conspecific Virus from an African Bat

(2014) V. M. Corman et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response

(2014) K.-L. Siu et al.   JOURNAL OF VIROLOGY

Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study

(2014) Ali S Omrani et al.   LANCET INFECTIOUS DISEASES

Rapid generation of a mouse model for Middle East respiratory syndrome

(2014) Jincun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spread, Circulation, and Evolution of the Middle East Respiratory Syndrome Coronavirus

(2014) M. Cotten et al.   mBio

Membrane ectopeptidases targeted by human coronaviruses

(2014) Berend Jan Bosch et al.   Current Opinion in Virology

Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus

(2014) Anna Lundin et al.   PLoS Pathogens

The emergence of the Middle East Respiratory Syndrome coronavirus

(2014) Shauna Milne-Price et al.   Pathogens and Disease

Innate Immune Response of Human Alveolar Type II Cells Infected with Severe Acute Respiratory Syndrome–Coronavirus

(2013) Zhaohui Qian et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research

(2013) Graham Simmons et al.   ANTIVIRAL RESEARCH

Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS

(2013) Jan Felix Drexler et al.   ANTIVIRAL RESEARCH

High Incidence but Low Burden of Coronaviruses and Preferential Associations between Respiratory Viruses

(2013) Q. Lepiller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Human bocavirus 1 infects commercially available primary human airway epithelium cultures productively

(2013) Xuefeng Deng et al.   JOURNAL OF VIROLOGICAL METHODS

Isolation and Characterization of Current Human Coronavirus Strains in Primary Human Epithelial Cell Cultures Reveal Differences in Target Cell Tropism

(2013) R. Dijkman et al.   JOURNAL OF VIROLOGY

TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium

(2013) S. Bertram et al.   JOURNAL OF VIROLOGY

Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells

(2013) X. Tao et al.   JOURNAL OF VIROLOGY

The Receptor Binding Domain of the New Middle East Respiratory Syndrome Coronavirus Maps to a 231-Residue Region in the Spike Protein That Efficiently Elicits Neutralizing Antibodies

(2013) H. Mou et al.   JOURNAL OF VIROLOGY

Tropism of and Innate Immune Responses to the Novel Human Betacoronavirus Lineage C Virus in Human Ex Vivo Respiratory Organ Cultures

(2013) R. W. Y. Chan et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist

(2013) D. Niemeyer et al.   JOURNAL OF VIROLOGY

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Cell Host Response to Infection with Novel Human Coronavirus EMC Predicts Potential Antivirals and Important Differences with SARS Coronavirus

(2013) L. Josset et al.   mBio

Efficient Replication of the Novel Human Betacoronavirus EMC on Primary Human Epithelium Highlights Its Zoonotic Potential

(2013) E. Kindler et al.   mBio

Novel polymeric inhibitors of HCoV-NL63

(2012) Aleksandra Milewska et al.   ANTIVIRAL RESEARCH

Building and maintaining the epithelium of the lung

(2012) Craig R. Rackley et al.   JOURNAL OF CLINICAL INVESTIGATION

Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry

(2012) M. Kawase et al.   JOURNAL OF VIROLOGY

Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63

(2012) J. Huynh et al.   JOURNAL OF VIROLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human parainfluenza virus serotypes differ in their kinetics of replication and cytokine secretion in human tracheobronchial airway epithelium

(2012) Anne Schaap-Nutt et al.   VIROLOGY

The chemokine receptor CXCR2 and coronavirus-induced neurologic disease

(2012) Jason G. Weinger et al.   VIROLOGY

Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence

(2012) Taylor Heald-Sargent et al.   Viruses-Basel

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

(2011) Susanne Pfefferle et al.   PLoS Pathogens

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia

(2010) Alejandro A. Pezzulo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Culturing the Unculturable: Human Coronavirus HKU1 Infects, Replicates, and Produces Progeny Virions in Human Ciliated Airway Epithelial Cell Cultures

(2010) K. Pyrc et al.   JOURNAL OF VIROLOGY

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

The Pediatric Burden of Human Coronaviruses Evaluated for Twenty Years

(2010) H Keipp Talbot et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Animal models for the study of influenza pathogenesis and therapy

(2009) Dale L. Barnard   ANTIVIRAL RESEARCH

Human Bocavirus Can Be Cultured in Differentiated Human Airway Epithelial Cells

(2009) R. Dijkman et al.   JOURNAL OF VIROLOGY

Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction

(2008) H.-X. Lin et al.   JOURNAL OF GENERAL VIROLOGY

Systematic Assembly of a Full-Length Infectious Clone of Human Coronavirus NL63

(2008) E. F. Donaldson et al.   JOURNAL OF VIROLOGY

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

(2008) Kèvin Knoops et al.   PLOS BIOLOGY

SARS-Coronavirus Replication/Transcription Complexes Are Membrane-Protected and Need a Host Factor for Activity In Vitro

(2008) Martijn J. van Hemert et al.   PLoS Pathogens

SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium

(2007) Amy C. Sims et al.   VIRUS RESEARCH