Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis

Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease

(2020) Jia Meng et al.   ACTA PHARMACOLOGICA SINICA

Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice

(2019) Bing Wan et al.   BIOSCIENCE REPORTS

Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y

(2019) Chengyuan Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats

(2019) Lei Ren   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Ganoderic acid A holds promising cytotoxicity on human glioblastoma mediated by incurring apoptosis and autophagy and inactivating PI3K/AKT signaling pathway

(2019) Yong Cheng et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia/reperfusion injury

(2019) Qi Cao et al.   KIDNEY INTERNATIONAL

Mechanisms of haemolysis-induced kidney injury

(2019) Kristof Van Avondt et al.   Nature Reviews Nephrology

Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy

(2019) April C. E. van Gennip et al.   PLoS One

Dexmedetomidine-mediated protection against septic liver injury depends on TLR4/MyD88/NF-κB signaling downregulation partly via cholinergic anti-inflammatory mechanisms

(2019) Shuang-feng Zi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cross-talk between the nervous system and the kidney

(2019) Shinji Tanaka et al.   KIDNEY INTERNATIONAL

Identification of Hub Genes and Pathways in a Rat Model of Renal Ischemia-Reperfusion Injury Using Bioinformatics Analysis of the Gene Expression Omnibus (GEO) Dataset and Integration of Gene Expression Profiles

(2019) Ao Guo et al.   MEDICAL SCIENCE MONITOR

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

(2019) Xiao-qiang Geng et al.   ACTA PHARMACOLOGICA SINICA

Deacetyl Ganoderic Acid F Inhibits LPS-Induced Neural Inflammation via NF-κB Pathway Both In Vitro and In Vivo

(2019) Feiya Sheng et al.   Nutrients

Initiation of the inflammatory response after renal ischemia/reperfusion injury during renal transplantation

(2018) Lijuan Gu et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Network pharmacology analysis of the anti-cancer pharmacological mechanisms of Ganoderma lucidum extract with experimental support using Hepa1-6-bearing C57 BL/6 mice

(2018) Ruo-lin Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury

(2018) Bing Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lentivirus-Mediated Silencing of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 Inhibits Release of Inflammatory Cytokines and Apoptosis in Renal Tubular Epithelial Cells Via Inhibition of the TLR4/NF-kB Pathway in Renal Ischemia-Reperfusion Injury

(2018) Jing-Fei Teng et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB Pathway

(2018) Yanzhe Wang et al.   Frontiers in Neurology

Ganoderic acid A against cyclophosphamide-induced hepatic toxicity in mice

(2018) Xu Lixin et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Ischemia-reperfusion injury in renal transplantation: 3 key signaling pathways in tubular epithelial cells

(2018) Stephanie F. Smith et al.   KIDNEY INTERNATIONAL

The multifaceted role of complement in kidney transplantation

(2018) Ali-Reza Biglarnia et al.   Nature Reviews Nephrology

Ganoderic acid, lanostanoid triterpene: a key player in apoptosis

(2017) Balraj Singh Gill et al.   INVESTIGATIONAL NEW DRUGS

Octreotide Ameliorates Renal Ischemia/Reperfusion Injury via Antioxidation and Anti-inflammation

(2017) Z. Xu et al.   TRANSPLANTATION PROCEEDINGS

Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update

(2017) Hua Su et al.   Frontiers in Immunology

Current Paradigm for Ischemia in Kidney Surgery

(2016) Maria C. Mir et al.   JOURNAL OF UROLOGY

Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress

(2015) Dandan Zhong et al.   Scientific Reports

Transcriptome Analysis of Renal Ischemia/Reperfusion Injury and Its Modulation by Ischemic Pre-Conditioning or Hemin Treatment

(2012) Matheus Correa-Costa et al.   PLoS One

Advances in understanding ischemic acute kidney injury

(2011) Raj Munshi et al.   BMC Medicine

Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4

(2011) Jianlin Chen et al.   KIDNEY INTERNATIONAL

Pathophysiology of ischemic acute kidney injury

(2011) Asif A. Sharfuddin et al.   Nature Reviews Nephrology

Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine?

(2010) Emmanuel Lorne et al.   INTENSIVE CARE MEDICINE

Fresh and cryopreserved, uncultured adipose tissue-derived stem and regenerative cells ameliorate ischemia–reperfusion-induced acute kidney injury

(2010) Zheng Feng et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells

(2009) Ryousuke Satou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients

(2009)   NEW ENGLAND JOURNAL OF MEDICINE