Fucoxanthin Attenuates Oxidative Damage by Activating the Sirt1/Nrf2/HO-1 Signaling Pathway to Protect the Kidney from Ischemia-Reperfusion Injury

Fucoxanthin Prevents 6-OHDA-Induced Neurotoxicity by Targeting Keap1

(2021) Wei Wu et al.   Oxidative Medicine and Cellular Longevity

Kaempferol Improves Lung Ischemia-Reperfusion Injury via Antiinflammation and Antioxidative Stress Regulated by SIRT1/HMGB1/NF-κB Axis

(2020) Chunli Yang et al.   Frontiers in Pharmacology

Activation of sirtuin1 protects against ischemia/reperfusion-induced acute kidney injury

(2020) Li Gong et al.   BIOMEDICINE & PHARMACOTHERAPY

Roles of Nrf2 in Protecting the Kidney from Oxidative Damage

(2020) Masahiro Nezu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of Gut Microbiota by Fucoxanthin During Alleviation of Obesity in High-Fat Diet-Fed Mice

(2020) Xiaowen Sun et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Fucoxanthin Mitigates Subarachnoid Hemorrhage-Induced Oxidative Damage via Sirtuin 1-Dependent Pathway

(2020) Xiang-Sheng Zhang et al.   MOLECULAR NEUROBIOLOGY

Fucoxanthin attenuates LPS-induced acute lung injury via inhibition of the TLR4/MYD88 signaling axis

(2020) Xiaoling Li et al.   Aging-US

Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice

(2020) Xiang‐Sheng Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fucoxanthin Protects Against oxLDL‐Induced Endothelial Damage via Activating the AMPK‐Akt‐CREB‐PGC1α Pathway

(2019) Hsiu‐Chung Ou et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress

(2019) Hao Liu et al.   Redox Biology

Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

(2019) Pallab Shaw et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibiting microRNA-29a protects myocardial ischemia-reperfusion injury by targeting SIRT1 and regulating NLRP3 and apoptosis pathway

(2019) Shoukun Ding et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation

(2019) Jiawen Zheng et al.   Marine Drugs

Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling

(2019) Kyeong-Eun Yang et al.   Journal of Ginseng Research

Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury

(2019) Changhui Diao et al.   Oxidative Medicine and Cellular Longevity

Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases

(2019) Zoltan Ungvari et al.   GeroScience

Fucoxanthin Alleviates Oxidative Stress through Akt/Sirt1/FoxO3α Signaling to Inhibit HG-Induced Renal Fibrosis in GMCs

(2019) Guanyu Yang et al.   Marine Drugs

Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats

(2019) Jianjian Zhang et al.   Molecular Medicine Reports

Calycosin ameliorates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1–NOD‐like receptor protein 3 pathway

(2019) Jinghui Zhai et al.   PHYTOTHERAPY RESEARCH

Dietary Fucoxanthin Induces Anoikis in Colorectal Adenocarcinoma by Suppressing Integrin Signaling in a Murine Colorectal Cancer Model

(2019) Masaru Terasaki et al.   Journal of Clinical Medicine

Crosstalk between Connexin 32 and mitochondrial apoptotic signaling pathway plays a pivotal role in renal ischemia reperfusion–induced acute kidney injury

(2018) Chaojin Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Fucoxanthin attenuates fatty acid-induced lipid accumulation in FL83B hepatocytes through regulated Sirt1/AMPK signaling pathway

(2018) Yi-Hsien Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys

(2018) Wenyan Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury

(2018) Yu Gu et al.   Journal of Translational Medicine

A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury

(2018) Jan R. Thiele et al.   Frontiers in Immunology

Cardioprotection of CAPE- o NO 2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro

(2018) Dejuan Li et al.   Redox Biology

Sirt1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia

(2018) Tao Chen et al.   Redox Biology

Neuroprotective role of fucoxanthin against cerebral ischemic/reperfusion injury through activation of Nrf2/HO-1 signaling

(2018) Lixun Hu et al.   BIOMEDICINE & PHARMACOTHERAPY

Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1-dependent mitochondrial oxidative damage

(2018) Bing Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Global epidemiology and outcomes of acute kidney injury

(2018) Eric A. J. Hoste et al.   Nature Reviews Nephrology

Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging

(2018) Svetlana M. Stamatovic et al.   NEUROBIOLOGY OF DISEASE

Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway

(2018) Si Shi et al.   BIOSCIENCE REPORTS

Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

(2017) Yi Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/Reperfusion: From mouse to human

(2017) Kojiro Nakamura et al.   LIVER TRANSPLANTATION

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

(2016) Edward T. Chouchani et al.   Cell Metabolism

SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro

(2016) YING-WEI DING et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Marine carotenoids: Bioactivities and potential benefits to human health

(2015) Hoang Van Chuyen et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protective effects of astaxanthin against ischemia/reperfusion induced renal injury in mice

(2015) Xuefeng Qiu et al.   Journal of Translational Medicine

Sirtuin and metabolic kidney disease

(2015) Shu Wakino et al.   KIDNEY INTERNATIONAL

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells

(2013) Kaipeng Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury

(2013) Hong Fan et al.   KIDNEY INTERNATIONAL

Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function

(2010) Kazuhiro Hasegawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term Risk of Mortality and Other Adverse Outcomes After Acute Kidney Injury: A Systematic Review and Meta-analysis

(2009) Steven G. Coca et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Nonrecovery of Kidney Function and Death after Acute on Chronic Renal Failure

(2009) C.-y. Hsu et al.   Clinical Journal of the American Society of Nephrology

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH)

(2009) Fumiaki Beppu et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model

(2009) Maeda   Molecular Medicine Reports

Acute Kidney Injury Increases Risk of ESRD among Elderly

(2008) A. Ishani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY