Reviewing the role of the orexinergic system and stressors in modulating mood and reward-related behaviors

Blockade of orexin receptors in the ventral tegmental area reduced the extinction period of the lateral hypothalamic-induced conditioned place preference in rats

(2021) Maedeh Mahmoudi et al.   BEHAVIOURAL PHARMACOLOGY

Orexin receptor antagonists reverse aberrant dopamine neuron activity and related behaviors in a rodent model of stress-induced psychosis

(2021) Hannah B. Elam et al.   Translational Psychiatry

The Dual Orexin Receptor Antagonist DORA-22 Improves Mild Stress-induced Sleep Disruption During the Natural Sleep Phase of Nocturnal Rats

(2021) Mackenzie C. Gamble et al.   NEUROSCIENCE

Orexin-2 receptor antagonism in the cornu ammonis 1 region of hippocampus prevented the antinociceptive responses induced by chemical stimulation of the lateral hypothalamus in the animal model of persistent pain

(2021) Pooya Pourreza et al.   BEHAVIOURAL PHARMACOLOGY

Synthesis and biological evaluation of novel 18F-labeled phenylbenzofuran-2-carboxamide derivative for detection of orexin 1 receptor in the brain

(2021) Hiroyuki Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Age-specific treatment effects of orexin/hypocretin-receptor antagonism on methamphetamine-seeking behavior

(2021) Natalie E. Zlebnik et al.   DRUG AND ALCOHOL DEPENDENCE

Blockade of orexin receptors in the hippocampal dentate gyrus reduced the extinction latency of morphine-induced place preference in male rats

(2021) Kimia RayatSanati et al.   NEUROSCIENCE LETTERS

Orexin 2 receptor in the nucleus accumbens is critical for the modulation of acute stress-induced anxiety

(2021) Bin Li et al.   PSYCHONEUROENDOCRINOLOGY

Significance of the orexinergic system in modulating stress-related responses in an animal model of post-traumatic stress disorder

(2020) Shlomi Cohen et al.   Translational Psychiatry

Investigating the role of the amygdala orexin receptor 1 in memory acquisition and extinction in a rat model of PTSD

(2020) Sudabeh Salehabadi et al.   BEHAVIOURAL BRAIN RESEARCH

Chemical stimulation of the lateral hypothalamus induced seeking behaviors in rats: Involvement of orexin receptors in the ventral tegmental area

(2020) Maedeh Mahmoudi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential Roles of Intra-accumbal Orexin Receptors in Acquisition and Expression of Methamphetamine-Induced Conditioned Place Preference in the Rats

(2020) Elahe Khosrowabadi et al.   NEUROCHEMICAL RESEARCH

High-fat diet induces time-dependent synaptic plasticity of the lateral hypothalamus

(2020) Victoria Linehan et al.   Molecular Metabolism

Orexin A injection into the ventral medial prefrontal cortex induces antidepressant-like effects: Possible involvement of local Orexin-1 and Trk receptors

(2020) L.A. Stanquini et al.   BEHAVIOURAL BRAIN RESEARCH

The orexin receptors in the ventral tegmental area are involved in the development of sensitization to expression of morphine-induced preference in rats

(2020) Dorna Mahmoudi et al.   BEHAVIOURAL PHARMACOLOGY

Orexin deficiency modulates cognitive flexibility in a sex‐dependent manner

(2020) Archana Durairaja et al.   GENES BRAIN AND BEHAVIOR

Orexin-1 receptor signaling within the lateral hypothalamus, but not bed nucleus of the stria terminalis, mediates context-induced relapse to alcohol seeking

(2020) Erin J Campbell et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues

(2020) Joshua L. Haight et al.   PSYCHOPHARMACOLOGY

Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans

(2020) Giacomo Salvadore et al.   Translational Psychiatry

Stress and the dopaminergic reward system

(2020) Ja-Hyun Baik   EXPERIMENTAL AND MOLECULAR MEDICINE

Irreversible hippocampal changes induced by high fructose diet in rats

(2020) Juan Fierros-Campuzano et al.   NUTRITIONAL NEUROSCIENCE

A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory

(2020) Jung Yoon Choi et al.   Cell Reports

Non-selective orexin-receptor antagonist attenuates stress-re-stress-induced core PTSD-like symptoms in rats: Behavioural and neurochemical analyses

(2020) Santosh Kumar Prajapati et al.   BEHAVIOURAL BRAIN RESEARCH

Synergistic effect of orexin-glutamate co-administration on spontaneous discharge rate of locus coeruleus neurons in morphine-dependent rats

(2019) Bita Hooshmand et al.   NEUROSCIENCE LETTERS

Sex- and Stress-Dependent Effects on Dendritic Morphology and Spine Densities in Putative Orexin Neurons

(2019) Laura A. Grafe et al.   NEUROSCIENCE

Role of orexin-1 and -2 receptors within the nucleus accumbens in the acquisition of sensitization to morphine in rats

(2019) Nasim Assar et al.   BEHAVIOURAL BRAIN RESEARCH

Orexin in the Posterior Paraventricular Thalamus Mediates Hunger-Related Signals in the Nucleus Accumbens Core

(2019) Julie Meffre et al.   CURRENT BIOLOGY

Orexinergic modulation of serotonin neurons in the dorsal raphe of a diurnal rodent, Arvicanthis niloticus

(2019) Widya Adidharma et al.   HORMONES AND BEHAVIOR

Orexin-1 Receptor Signaling in Ventral Pallidum Regulates Motivation for the Opioid Remifentanil

(2019) Aida Mohammadkhani et al.   JOURNAL OF NEUROSCIENCE

Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine–Glutamate Co-release as Future Target in Substance Use Disorder

(2019) Zisis Bimpisidis et al.   Journal of Clinical Medicine

Role of orexinergic receptors in the dentate gyrus of the hippocampus in the acquisition and expression of morphine-induced conditioned place preference in rats

(2019) Mohammadreza Shirazy et al.   BEHAVIOURAL BRAIN RESEARCH

Involvement of orexin receptors within the hippocampal dentate gyrus in morphine-induced reinstatement in food-deprived rats

(2019) Mahsa Pourhamzeh et al.   BEHAVIOURAL BRAIN RESEARCH

Forced ethanol ingestion by Wistar rats from a juvenile age increased voluntary alcohol consumption in adulthood, with the involvement of orexin-A

(2018) Luis-Gabriel Mendoza-Ruiz et al.   ALCOHOL

Role of the orexin receptors within the nucleus accumbens in the drug priming-induced reinstatement of morphine seeking in the food deprived rats

(2018) Marjan Sahafzadeh et al.   BRAIN RESEARCH BULLETIN

Role of orexin-1 and orexin-2 receptors in the CA1 region of hippocampus in the forced swim stress- and food deprivation-induced reinstatement of morphine seeking behaviors in rats

(2018) Pariya Edalat et al.   BRAIN RESEARCH BULLETIN

Orexins and stress

(2018) Laura A. Grafe et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Increased acetylcholine and glutamate efflux in the prefrontal cortex following intranasal orexin-A (hypocretin-1)

(2018) Coleman B. Calva et al.   JOURNAL OF NEUROCHEMISTRY

Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats

(2018) Brooke E. Schmeichel et al.   NEUROPSYCHOPHARMACOLOGY

Orexin-A/hypocretin-1 Immunoreactivity in the Lateral Hypothalamus is Reduced in Genetically Obese but not in Diet-induced Obese Mice

(2018) J. Antonio González et al.   NEUROSCIENCE

Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats

(2018) Sharareh Farahimanesh et al.   PEPTIDES

Orexin prevents depressive-like behavior by promoting stress resilience

(2018) Miao-Jin Ji et al.   MOLECULAR PSYCHIATRY

Involvement of orexinergic receptors in the nucleus accumbens, in the effect of forced swim stress on the reinstatement of morphine seeking behaviors

(2018) Zahra Farzinpour et al.   BEHAVIOURAL BRAIN RESEARCH

Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits

(2018) Saeedeh Bahramzadeh Zoeram et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss

(2018) C.M. Duffy et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Differential effect of amphetamine over the corticotropin-releasing factor CRF2 receptor, the orexin OX1 receptor and the CRF2-OX1 heteroreceptor complex

(2018) Gemma Navarro et al.   NEUROPHARMACOLOGY

Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats

(2018) Mirmohammadali Mirramezani Alizamini et al.   PEPTIDES

Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain

(2018) Javier Franco-Pérez et al.   Nutrients

Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson’s Disease

(2018) Mei-Fang Liu et al.   Frontiers in Neuroscience

Involvement of orexin-2 receptor in the ventral tegmental area in stress- and drug priming-induced reinstatement of conditioned place preference in rats

(2018) Ronak Azizbeigi et al.   NEUROSCIENCE LETTERS

Intra-periaqueductal gray matter administration of orexin-A exaggerates pulpitis-induced anxiogenic responses and c-fos expression mainly through the interaction with orexin 1 and cannabinoid 1 receptors in rats

(2018) Ali Mohammad Pourrahimi et al.   NEUROPEPTIDES

Neuromodulation of orexin neurons reduces diet-induced adiposity

(2017) A N Zink et al.   INTERNATIONAL JOURNAL OF OBESITY

Short-term high-fat diet primes excitatory synapses for long-term depression in orexin neurons

(2017) Victoria Linehan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

(2017) Marisela Morales et al.   NATURE REVIEWS NEUROSCIENCE

Orexin/hypocretin treatment restores hippocampal-dependent memory in orexin-deficient mice

(2017) Vijayakumar Mavanji et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Role of orexin receptors in the ventral tegmental area on acquisition and expression of morphine-induced conditioned place preference in the rats

(2017) Sharareh Farahimanesh et al.   NEUROPEPTIDES

Orexin 2 receptor regulation of the hypothalamic–pituitary–adrenal (HPA) response to acute and repeated stress

(2017) Laura A. Grafe et al.   NEUROSCIENCE

Role of intra-accumbal orexin receptors in the acquisition of morphine-induced conditioned place preference in the rats

(2017) Mirmohammadali Mirramezani Alizamini et al.   NEUROSCIENCE LETTERS

Reward Circuitry in Addiction

(2017) Sarah Cooper et al.   Neurotherapeutics

Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

(2017) Pascal Bonaventure et al.   Frontiers in Pharmacology

Ventral tegmental area orexin 1 receptors promote palatable food intake and oppose postingestive negative feedback

(2016) Sarah J. Terrill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Differential roles of orexin receptors within the dentate gyrus in stress- and drug priming-induced reinstatement of conditioned place preference in rats.

(2016) Fereshte Ebrahimian et al.   BEHAVIORAL NEUROSCIENCE

Stress-induced remodeling of hippocampal CA3 pyramidal neurons

(2016) Bruce S. McEwen   BRAIN RESEARCH

Involvement of orexin-1 and orexin-2 receptors within the dentate gyrus of the hippocampus in the acquisition, expression and extinction of lateral hypothalamic-induced conditioned place preference in the rats

(2016) Shahrnaz Parsania et al.   BRAIN RESEARCH

Sex-specific effects of relaxin-3 on food intake and body weight gain

(2016) Juliane Calvez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner

(2016) David E. Moorman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats

(2016) Elham Kordi Jaz et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Dopaminergic projections of the subparafascicular thalamic nucleus to the auditory brainstem

(2016) Alexander A. Nevue et al.   HEARING RESEARCH

Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant

(2016) T Lau et al.   MOLECULAR PSYCHIATRY

The role of trigeminal nucleus caudalis orexin 1 receptor in orofacial pain-induced anxiety in rat

(2016) Mehri Bahaaddini et al.   NEUROREPORT

Differential effects of intra-accumbal orexin-1 and -2 receptor antagonists on the expression and extinction of morphine-induced conditioned place preference in rats

(2016) Fatemeh Sadeghzadeh et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effects of dorsal hippocampal orexin-2 receptor antagonism on the acquisition, expression, and extinction of morphine-induced place preference in rats

(2016) Bahman Sadeghi et al.   PSYCHOPHARMACOLOGY

Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

(2016) Li-Wei Tung et al.   Nature Communications

Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in iP rats

(2015) Robyn Mary Brown et al.   ADDICTION BIOLOGY

Orexin A-mediated AKT signaling in the dentate gyrus contributes to the acquisition, expression and reinstatement of morphine-induced conditioned place preference

(2015) Sui-Jun Guo et al.   ADDICTION BIOLOGY

Role of intra-hippocampal orexin 1 and orexin 2 receptors in conditioned place preference induced by chemical stimulation of the lateral hypothalamus

(2015) Ali Rashidy-Pour et al.   BEHAVIOURAL BRAIN RESEARCH

The orexin-1 receptor antagonist SB-334867 decreases anxiety-like behavior and c-Fos expression in the hypothalamus of rats exposed to cat odor

(2015) M.W. Vanderhaven et al.   BEHAVIOURAL BRAIN RESEARCH

Role of dopamine D1-like receptor within the nucleus accumbens in acute food deprivation- and drug priming-induced reinstatement of morphine seeking in rats

(2015) Fatemeh Sadeghzadeh et al.   BEHAVIOURAL BRAIN RESEARCH

OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2-INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES

(2015) Philip L. Johnson et al.   DEPRESSION AND ANXIETY

Sex-Specific Effects of Relaxin-3 on Food Intake and Brain Expression of Corticotropin-Releasing Factor in Rats

(2015) Christophe Lenglos et al.   ENDOCRINOLOGY

A Stereological Analysis of NPY, POMC, Orexin, GFAP Astrocyte, and Iba1 Microglia Cell Number and Volume in Diet-Induced Obese Male Mice

(2015) Moyra B. Lemus et al.   ENDOCRINOLOGY

Differential effects of central administration of relaxin-3 on food intake and hypothalamic neuropeptides in male and female rats

(2015) J. Calvez et al.   GENES BRAIN AND BEHAVIOR

Orexin Signaling in the VTA Gates Morphine-Induced Synaptic Plasticity

(2015) C. Baimel et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of stress in the brain

(2015) Bruce S McEwen et al.   NATURE NEUROSCIENCE

Antidepressant effects of exercise are produced via suppression of hypocretin/orexin and melanin-concentrating hormone in the basolateral amygdala

(2015) Tae-Kyung Kim et al.   NEUROBIOLOGY OF DISEASE

Accumbal D1R Neurons Projecting to Lateral Hypothalamus Authorize Feeding

(2015) Eoin C. O’Connor et al.   NEURON

Stress Effects on Neuronal Structure: Hippocampus, Amygdala and Prefrontal Cortex

(2015) Bruce S McEwen et al.   NEUROPSYCHOPHARMACOLOGY

Functional interaction between the orexin-1 and CB1 receptors within the nucleus accumbens in the conditioned place preference induced by the lateral hypothalamus stimulation

(2015) Zahra Fatahi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Functional interaction between OX2 and CB1 receptors in the ventral tegmental area and the nucleus accumbens in response to place preference induced by chemical stimulation of the lateral hypothalamus

(2015) Fatemeh Yazdi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Ventral tegmental area dopamine revisited: effects of acute and repeated stress

(2015) Elizabeth N. Holly et al.   PSYCHOPHARMACOLOGY

Comprehensive Behavioral Analysis of Male Ox1r−/− Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior

(2015) Md. G. Abbas et al.   Frontiers in Behavioral Neuroscience

Increased number of orexin/hypocretin neurons with high and prolonged external stress-induced depression

(2014) Jaishree Jalewa et al.   BEHAVIOURAL BRAIN RESEARCH

Forced swim stress but not exogenous corticosterone could induce the reinstatement of extinguished morphine conditioned place preference in rats: Involvement of glucocorticoid receptors in the basolateral amygdala

(2014) Sara Karimi et al.   BEHAVIOURAL BRAIN RESEARCH

Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain

(2014) Jacqueline Vazquez-DeRose et al.   Brain Structure & Function

High fat diet induces specific pathological changes in hypothalamic orexin neurons in mice

(2014) Mizuki Nobunaga et al.   NEUROCHEMISTRY INTERNATIONAL

Blockade of orexin-1 receptors in the ventral tegmental area could attenuate the lateral hypothalamic stimulation-induced potentiation of rewarding properties of morphine

(2014) Leila Zarepour et al.   NEUROPEPTIDES

Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency

(2014) S.P. Deats et al.   NEUROSCIENCE

Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model

(2014) Spring Valdivia et al.   PLoS One

Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area

(2014) J. W. Muschamp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contributions of the paraventricular thalamic nucleus in the regulation of stress, motivation, and mood

(2014) David T. Hsu et al.   Frontiers in Behavioral Neuroscience

Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats

(2014) Morgan H. James et al.   Frontiers in Behavioral Neuroscience

Depressive behavior and activation of the orexin/hypocretin system.

(2013) David H. Arendt et al.   BEHAVIORAL NEUROSCIENCE

Role of dorsal hippocampal orexin-1 receptors in associating morphine reward with contextual stimuli

(2013) Esmail Riahi et al.   BEHAVIOURAL PHARMACOLOGY

Orexin receptors: Multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders

(2013) Tian-Rui Xu et al.   CELLULAR SIGNALLING

Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats

(2013) Robyn Mary Brown et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Hippocampal gene expression changes underlying stress sensitization and recovery

(2013) J D Gray et al.   MOLECULAR PSYCHIATRY

Consolidation of object recognition memory requires simultaneous activation of dopamine D1/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus

(2013) Janine I. Rossato et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course

(2013) Bruce S. McEwen et al.   NEURON

Reward and aversion in a heterogeneous midbrain dopamine system

(2013) Stephan Lammel et al.   NEUROPHARMACOLOGY

Involvement of orexin-2 receptors in the ventral tegmental area and nucleus accumbens in the antinociception induced by the lateral hypothalamus stimulation in rats

(2013) Hassan Azhdari-Zarmehri et al.   PEPTIDES

Central functions of the orexinergic system

(2013) Xiao-Yang Zhang et al.   Neuroscience Bulletin

Behavioral responses to orexin, orexin receptor gene expression, and spontaneous physical activity contribute to individual sensitivity to obesity

(2012) Claudio E. Perez-Leighton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Axonal branching patterns of ventral pallidal neurons in the rat

(2012) Anushree Tripathi et al.   Brain Structure & Function

Neurogenesis-Independent Antidepressant-Like Effects on Behavior and Stress Axis Response of a Dual Orexin Receptor Antagonist in a Rodent Model of Depression

(2012) Mathieu Nollet et al.   NEUROPSYCHOPHARMACOLOGY

The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus

(2012) C. Nocjar et al.   NEUROSCIENCE

Orexin A in the ventral tegmental area induces conditioned place preference in a dose-dependent manner: Involvement of D1/D2 receptors in the nucleus accumbens

(2012) Zahra Taslimi et al.   PEPTIDES

Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network

(2012) Philip L. Johnson et al.   PHYSIOLOGY & BEHAVIOR

Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats

(2012) Elizabeth A. Lungwitz et al.   PHYSIOLOGY & BEHAVIOR

Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats

(2012) Stephen V. Mahler et al.   PSYCHOPHARMACOLOGY

Orexin Receptors: Pharmacology and Therapeutic Opportunities

(2011) Thomas E. Scammell et al.   Annual Review of Pharmacology and Toxicology

Molecular modulation of prefrontal cortex: Rational development of treatments for psychiatric disorders.

(2011) Nao J. Gamo et al.   BEHAVIORAL NEUROSCIENCE

Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward

(2011) Daniel M. Hutcheson et al.   BEHAVIOURAL PHARMACOLOGY

The Selective Serotonin Reuptake Inhibitor Paroxetine, but not Fluvoxamine, Decreases Methamphetamine Conditioned Place Preference in Mice

(2011) Y. Takamatsu et al.   Current Neuropharmacology

Orexins/Hypocretins Act in the Posterior Paraventricular Thalamic Nucleus During Repeated Stress to Regulate Facilitation to Novel Stress

(2011) Willem Heydendael et al.   ENDOCRINOLOGY

Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence

(2011) Christoph von der Goltz et al.   HORMONES AND BEHAVIOR

Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking

(2011) Morgan H. James et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Orexin expression and promoter-methylation in peripheral blood of patients suffering from major depressive disorder

(2011) Andrea Rotter et al.   JOURNAL OF AFFECTIVE DISORDERS

Antidepressants recruit new neurons to improve stress response regulation

(2011) A Surget et al.   MOLECULAR PSYCHIATRY

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

Amygdala circuitry mediating reversible and bidirectional control of anxiety

(2011) Kay M. Tye et al.   NATURE

Increased numbers of orexin/hypocretin neurons in a genetic rat depression model

(2011) Elli Mikrouli et al.   NEUROPEPTIDES

Activation of orexin neurons in dorsomedial/perifornical hypothalamus and antidepressant reversal in a rodent model of depression

(2011) Mathieu Nollet et al.   NEUROPHARMACOLOGY

A time-dependent role of midline thalamic nuclei in the retrieval of fear memory

(2011) Nancy Padilla-Coreano et al.   NEUROPHARMACOLOGY

Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: A c-Fos study

(2011) Anne E. Panhelainen et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Stress- and Allostasis-Induced Brain Plasticity

(2010) Bruce S. McEwen et al.   Annual Review of Medicine

Orexin links emotional stress to autonomic functions

(2010) Tomoyuki Kuwaki   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Enduring and sex-specific effects of adolescent social isolation in rats on adult stress reactivity

(2010) Ari Weintraub et al.   BRAIN RESEARCH

Subjective neuronal coding of reward: temporal value discounting and risk

(2010) Wolfram Schultz   EUROPEAN JOURNAL OF NEUROSCIENCE

The Brainstem Noradrenergic Systems in Stress, Anxiety and Depression

(2010) K. Itoi et al.   JOURNAL OF NEUROENDOCRINOLOGY

Orbitofrontal Cortex Lesions Alter Anxiety-Related Activity in the Primate Bed Nucleus of Stria Terminalis

(2010) A. S. Fox et al.   JOURNAL OF NEUROSCIENCE

Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

(2010) Ethan S. Bromberg-Martin et al.   NEURON

Hypocretin-1 (orexin A) prevents the effects of hypoxia/hypercapnia and enhances the GABAergic pathway from the lateral paragigantocellular nucleus to cardiac vagal neurons in the nucleus ambiguus

(2010) O. Dergacheva et al.   NEUROSCIENCE

Electrophysiological effects of orexin-B and dopamine on rat nucleus accumbens shell neurons in vitro

(2010) Kyohei Mori et al.   PEPTIDES

Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus

(2010) Yonghui Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effects of undernourishment on the hypothalamic orexinergic system

(2010) H. Pinos et al.   PHYSIOLOGY & BEHAVIOR

Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats

(2010) Yonghui Li et al.   PSYCHOPHARMACOLOGY

Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration

(2010) Rodrigo A. España et al.   PSYCHOPHARMACOLOGY

A Possible Mechanism Underlying an Antidepressive-Like Effect of Kososan, a Kampo Medicine, via the Hypothalamic Orexinergic System in the Stress-Induced Depression-Like Model Mice

(2009) Naoki Ito et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Reinstatement of Cocaine Seeking by Hypocretin (Orexin) in the Ventral Tegmental Area: Independence from the Local Corticotropin-Releasing Factor Network

(2009) Bin Wang et al.   BIOLOGICAL PSYCHIATRY

Brain stress systems in the amygdala and addiction

(2009) George F. Koob   BRAIN RESEARCH

Hypocretin /orexin contributes to the expression of some but not all forms of stress and arousal

(2009) Teri M. Furlong et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system

(2009) Rodrigo A. España et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Structural Integrity of an Amygdala-Prefrontal Pathway Predicts Trait Anxiety

(2009) M. J. Kim et al.   JOURNAL OF NEUROSCIENCE

A key role for orexin in panic anxiety

(2009) Philip L Johnson et al.   NATURE MEDICINE

The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization

(2009) Davide Quarta et al.   NEUROCHEMISTRY INTERNATIONAL

The Reward Circuit: Linking Primate Anatomy and Human Imaging

(2009) Suzanne N Haber et al.   NEUROPSYCHOPHARMACOLOGY

Steady-state methadone effect on generalized arousal in male and female mice.

(2008) N. Devidze et al.   BEHAVIORAL NEUROSCIENCE

Drug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal

(2008) Alexandre Surget et al.   BIOLOGICAL PSYCHIATRY

Increased orexin levels in the cerebrospinal fluid the first year after a suicide attempt

(2008) Lena Brundin et al.   JOURNAL OF AFFECTIVE DISORDERS

Paraventricular thalamic nucleus: Subcortical connections and innervation by serotonin, orexin, and corticotropin-releasing hormone in macaque monkeys

(2008) David T. Hsu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Vasopressin Increases Locomotion through a V1a Receptor in Orexin/Hypocretin Neurons: Implications for Water Homeostasis

(2008) T. Tsunematsu et al.   JOURNAL OF NEUROSCIENCE

Orexin Signaling Mediates the Antidepressant-Like Effect of Calorie Restriction

(2008) M. Lutter et al.   JOURNAL OF NEUROSCIENCE

Changes in brain orexin levels in a rat model of depression induced by neonatal administration of clomipramine

(2008) P. Feng et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Desipramine Reduces Stress-Activated Dynorphin Expression and CREB Phosphorylation in NAc Tissue

(2008) E. H. Chartoff et al.   MOLECULAR PHARMACOLOGY

Striatal and extrastriatal dopamine in the basal ganglia: An overview of its anatomical organization in normal and Parkinsonian brains

(2008) Yoland Smith et al.   MOVEMENT DISORDERS

I.c.v. administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation

(2008) N. Ito et al.   NEUROSCIENCE

Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: Involvement of opioids, orexin, oxytocin and NPY

(2008) Pawel K. Olszewski et al.   PEPTIDES

BOLD Responses Reflecting Dopaminergic Signals in the Human Ventral Tegmental Area

(2008) K. D'Ardenne et al.   SCIENCE

A top-down perspective on dopamine, motivation and memory

(2007) Anthony G. Phillips et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR